L-Lysine dihydrochloride
- CAS No.
- 657-26-1
- Chemical Name:
- L-Lysine dihydrochloride
- Synonyms
- L-(+)-LYSINE DIHYDROCHLORIDE;Lys.2Hcl;L-Lys.2Hcl;H-LYS-OH 2HCL;L-LYSINE 2HCL;H-Lys-OH·2HCI;L-LysineHCl-6-13C;L-Lysine dihydrate;L-Lysine-UL-13C6HCl;L-Lysine-UL-13C62HCl
- CBNumber:
- CB9251876
- Molecular Formula:
- C6H16Cl2N2O2
- Molecular Weight:
- 219.11
- MDL Number:
- MFCD00066389
- MOL File:
- 657-26-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 200-206 °C(lit.) |
|---|---|
| alpha | 14 º (c=2, water 18 ºC) |
| refractive index | 15 ° (C=2, H2O) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Crystalline Powder |
| color | White to very light yellow |
| Water Solubility | Soluble in water (100 mg/ml). |
| Sensitive | Hygroscopic |
| Merck | 14,5636 |
| BRN | 4539715 |
| InChI | InChI=1/C6H14N2O2.2ClH/c7-4-2-1-3-5(8)6(9)10;;/h5H,1-4,7-8H2,(H,9,10);2*1H/t5-;;/s3 |
| InChIKey | JBBURJFZIMRPCZ-WHWWGIJDNA-N |
| SMILES | [C@@H](N)(C(=O)O)CCCCN.Cl.Cl |&1:0,r| |
| CAS DataBase Reference | 657-26-1(CAS DataBase Reference) |
| FDA UNII | 90YFR6U9QC |
| EPA Substance Registry System | Lysine dihydrochloride (657-26-1) |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
| CAS Number Unlabeled | 657-26-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29224190 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
L-Lysine dihydrochloride price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L5751 | L-Lysine dihydrochloride ≥98% (HPLC) | 657-26-1 | 100g | $199 | 2026-04-30 | Buy |
| Sigma-Aldrich | L5751 | L-Lysine dihydrochloride ≥98% (HPLC) | 657-26-1 | 25g | $55.4 | 2023-06-20 | Buy |
| TCI Chemical | L0131 | L-(+)-Lysine Dihydrochloride >98.0%(T) | 657-26-1 | 25g | $27 | 2026-04-30 | Buy |
| Usbiological | 281516 | L-(+)-Lysine Dihydrochloride Asreported | 657-26-1 | 25g | $310 | 2026-06-03 | Buy |
| Usbiological | 281516 | L-(+)-Lysine Dihydrochloride Asreported | 657-26-1 | 50g | $425 | 2026-06-03 | Buy |
L-Lysine dihydrochloride Chemical Properties, Uses, Production
Chemical Properties
white to very light yellow crystalline powder
Uses
Synthesis of hyperbranched polylysine using the N-hydroxysuccinimide ester of L-lysine dihydrochloride as AB 2 building block. The histidine and lysine standards were prepared from L-histidine monohydro- chloride and L-lysine dihydrochloride respectively. L-Homocitrulline-The copper complex was prepared from L-lysine dihydrochloride in 80 to 86 per cent yields.
Biological Activity
L-Lysine is an essential proteinogenic α amino acid used in a wide range of applications including as a supplement in cell culture media; a substrate of enzymes such as L-lysine oxidase (EC 1.4.3.14); a component of poly-lysine polymers; and a substrate for oxidation and glycation mechanism studies.
Synthesis
L-lysine dihydrochloride is an organic intermediate that can be obtained from Boc-Lys-OH as a feedstock by removing the protective groups. HCl (4 M in dioxane, 2.5 mL, 10.0 mmol, 10.0 equiv) was added to a solution of Boc-Lys-OH (297 mg, 1.00 mmol) in MeOH (10 mL). The reaction mixture was stirred for 24 h at room temperature. The solvent was removed under vacuum. The residue was dried under high vacuum for 4 hours to obtain the product.
Purification Methods
Crystallise it from MeOH, in the presence of excess HCl, by adding diethyl ether. [Yoneya J Biochem (Tokyo) 38 343 1951, Kearley & Ingersoll J Am Chem Soc 73 5783 1951, Beilstein 4 IV 2717.]
L-Lysine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qingdao Tenglong microwave technology co., LTD. | 0532-83818797 17669478191 | sc@tlwb.com.cn | China | 3933 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from L-Lysine dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | L-Lys.2Hcl
657-26-1
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd
|
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 |
2024-04-19 | L-Lysine dihydrochloride
657-26-1
|
$30.00 | 1kg | 99.7% | 200000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-04-18 | L-Lysine dihydrochloride
657-26-1
|
$30.00 | 1kg | 99.7% | 200000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- L-Lys.2Hcl
657-26-1
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- L-Lysine dihydrochloride
657-26-1
- $30.00
- 99.7%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- L-Lysine dihydrochloride
657-26-1
- $30.00
- 99.7%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
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