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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline structure

CAS No.: 694499-26-8

Chemical Name:: 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline

Synonyms: PON50;SW-53;SWF-53;AP24592;RMA-315;Ponatinib int2;Ponatinib Impurity 3;Pralsetinib Impurity 1;Ponatinib Amine impurity;Intermediate of Ponatinib

CBNumber:: CB92520701

Molecular Formula:: C13H18F3N3

Molecular Weight:: 273.3

MDL Number:: MFCD09909924

MOL File:: 694499-26-8.mol

MSDS File:: SDS

Last updated:2026-07-25 07:39:42

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4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Properties

Boiling point	329.1±42.0 °C(Predicted)
Density	1.227
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	7.55±0.10(Predicted)
form	Solid
color	Light yellow to yellow
InChI	InChI=1S/C13H18F3N3/c1-18-4-6-19(7-5-18)9-10-2-3-11(17)8-12(10)13(14,15)16/h2-3,8H,4-7,9,17H2,1H3
InChIKey	ZMWAZMYBMAAMAW-UHFFFAOYSA-N
SMILES	C1(N)=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1
FDA UNII	KFW56NE7FT

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H332-H315-H319-H335
Precautionary statements	P280
HS Code	2933599590

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	283065	4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Asreported	694499-26-8	500mg	$368	2026-06-03	Buy
Usbiological	283065	4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Asreported	694499-26-8	1g	$508	2026-06-03	Buy
Usbiological	283065	4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Asreported	694499-26-8	2g	$694	2026-06-03	Buy
Usbiological	283065	4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Asreported	694499-26-8	5g	$990	2026-06-03	Buy
Usbiological	283065	4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Asreported	694499-26-8	10g	$1351	2026-06-03	Buy

Product number	Packaging	Price	Buy
283065	500mg	$368	Buy
283065	1g	$508	Buy
283065	2g	$694	Buy
283065	5g	$990	Buy
283065	10g	$1351	Buy

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Chemical Properties, Uses, Production

Chemical Properties

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline is a pale yellow to yellow solid at room temperature, with a predicted boiling point of 329.1±42.0°C (760 mmHg), a density of 1.227 g/cm³ (or 1.2±0.1 g/cm³), a predicted pKa of 7.55±0.10, a flash point of 152.9±27.9°C, a refractive index of 1.529, and an extremely low vapor pressure (0.0±0.7 mmHg at 25°C). It needs to be stored at 2-8°C in a light-protected, sealed environment under an inert gas (nitrogen or argon) atmosphere.

Uses

4-(6-Acryloyloxyhexyloxy)-benzoesure (4-cyanophenylester) can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and in the process of chemical and pharmaceutical synthesis.

Synthesis

Synthesis_694499-26-8
4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline Into a solution 4-methyl-1-(4-nitro-2-(trifluoromethyl)benzyl)piperazine (1.5 g, 5 mmol) in MeOH (250 mL) was added Raney Nickel (0.15 g, 10 wt %). The suspension was stirred under hydrogen atmosphere (50 psi) for 24 hrs and monitored by TLC. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure to yield the desired product (1.36 g, 100%). 1H NMR (300 MHz, CDCl3) |: 7.43-7.46 (1H, d, J=9.0 Hz), 6.91 (1H, s), 6.77-6.80 (1H, d J=9.0 Hz), 3.77 (2H, s), 3.54 (2H, s), 2.53 (8H, brs), 2.34 (3H, s).

storage

Store long-term at 2-8°C.

References

[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 20, p. 7150 - 7163
[2] Patent: CN105461659, 2016, A. Location in patent: Paragraph 0032; 0033; 0034; 0065; 0066; 0067
[3] Patent: WO2015/186137, 2015, A1. Location in patent: Page/Page column 19
[4] Patent: WO2005/51366, 2005, A2. Location in patent: Page/Page column 62

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline synthesis

Synthesis of 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline from Acetamide, 2,2,2-trifluoro-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

[4-AMino-2-(trifluoroMethyl)phenyl](4-Methyl-1-piperazinyl)Metha Tetrahydrofuran Aluminum chloride Lithium Aluminum Hydride

Preparation Products

Olverembatinib GZD856

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Suppliers

Global Suppliers ( 242)

Supplier	Tel	Email	Country	ProdList	Advantage
JiangYin Ruisheng Chemical Co., Ltd.	13003356808	1485751188@qq.com	China	403	55
Hunan Huayi Zhide Pharmaceutical Technology Co., Ltd.	17752881701	190060276@qq.com	China	199	58
Changzhou Chemscaler Pharmtech Co., Ltd.	0519-81096292 15312577869	chemscaler@yahoo.com.cn	China	300	60
Shanghai PharmOrgsyn Technology Co., LTD.	021-+86-021-38228826	sales@pharmorgsyn.cn	China	250	58
Haohong (Qihe) Medical Technology Co., LTD	0534-2152677 18660163165	sale@inyelchem.com	China	296	58
NANJING WEDO PHARMATECH CO.,LTD.	15189836218	wedo-chem@huawe.com	China	240	58
Anqing CHICO Pharmaceutical Co., Ltd.	18061456370	david@chicopharm.com	China	461	58
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Suzhou Zehou Biotechnology Co. , Ltd.	0512-68716880 19984816880	sales@growingchem.com	China	229	64
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64

Supplier	Advantage
JiangYin Ruisheng Chemical Co., Ltd.	55
Hunan Huayi Zhide Pharmaceutical Technology Co., Ltd.	58
Changzhou Chemscaler Pharmtech Co., Ltd.	60
Shanghai PharmOrgsyn Technology Co., LTD.	58
Haohong (Qihe) Medical Technology Co., LTD	58
NANJING WEDO PHARMATECH CO.,LTD.	58
Anqing CHICO Pharmaceutical Co., Ltd.	58
Energy Chemical	61
Suzhou Zehou Biotechnology Co. , Ltd.	64
Accela ChemBio Co.,Ltd.	64

View Latest Price from 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 694499-26-8	$1.00	1g	99%	100kg	RongNa Biotechnology Co.,Ltd
2026-08-20	4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline USP/EP/BP 694499-26-8	$1.10	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2026-07-25	4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 694499-26-8		1kg	98%	1000kgs	Shaanxi Dideu New Materials Co. Ltd

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
694499-26-8
$1.00
99%
RongNa Biotechnology Co.,Ltd

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline USP/EP/BP
694499-26-8
$1.10
99.9%
Dideu Industries Group Limited

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline
694499-26-8
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline Spectrum

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline(694499-26-8)¹HNMR

694499-26-8 (4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline) Related Search:

1-Methyl-4-[[4-nitro-2-(trifluoromethyl)phenyl]methyl]-piperazine 1-(bromomethyl)-4-nitro-2-(trifluoromethyl)benzene 2,4-dichloro-7H-Pyrrolo[2,3-d]pyriMidine-7-carboxylic acid 1,1-diMethylethyl ester rac-4-(6-chloro-2-oxo-2,3-dihydro-1H-indol-3-yl)-piperidine-1-carboxylic acid tert-butyl SW-41

(6-Methylpyridazin-3-yl)MethanaMine dihydrochloride tert-butyl 4-(4-broMothiazol-2-yl)piperazine-1-carboxylate 2-Methylpiperazine 1,2-Dimethylhydrazine Dihydrochloride 1-Methylpiperazine

MK-1775 Niraparib Ponatinib Hydrochloride Galeterone Ponatinib

5-Methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-amine 5-Bromo-2-methyl-3-nitrophenyl methylcarboxylate 1-Methyl-5-nitro-1H-indazole

1of4

4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline 4-((4-Methylpiperazin-1-yl)methyl)-3-trifluoromethylphenylamine 4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline 4-[(4-Methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzenamine BenzenaMine, 4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)- 4-[(4-Methyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)aniline 4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline 95+% 5-Amino-2-[(4-methylpiperazin-1-yl)methyl]benzotrifluoride, 1-[4-Amino-2-(trifluoromethyl)benzyl]-4-methylpiperazine 4-(4-Methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline 4-((4-Methylpiperazin-1-yl)methyl)-3-trifluoromethylphenylamine Ponatinib Impurity 3 Ponatinib int2 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline IN Stock 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline IN Stock COA TDS free sample 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline TDS msds coa PON50 4-(4-METHYLPIPERAZINOMETHYL)-3-(TRIFLUOROMETHYL)ANILINE 694499-26-8 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline USP/EP/BP SWF-53 SW-53 Benzenamine, 4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoro... 3-(trifluoromethyl)-4-((4-methylpiperazin-1-yl)methyl)benzenamine 4-(4-Methylpiperazinomethyl)-3-(trifluoromethyl)aniline-d8 4-(4-Methylpiperazinomethyl)-4-(trifluoromethyl)aniline 1-[4-Amino-2-(Trifluoromethyl)benzyl]-4-MethylPiperazine 4-(4-Methylpiperazinomethyl)-3- Pralsetinib Impurity 1 Intermediate of Ponatinib AP24592 3-(Trifluoromethyl)-4-[(4-methylpiperazin-1-yl)methyl]aniline RMA-315 (E)-3-((2-(2-cyanovinyl)-1H-imidazol-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide Ponatinib Amine impurity 694499-26-8