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tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Structure
tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate structure
CAS No.
203661-69-2
Chemical Name:
tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
Synonyms
2-Oxo-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester;ate tert-butyL;7-Boc-2-oxo-7-azaspiro[3....;7-Boc-2-oxo-7-azaspiro[3.5]nonane;N-Boc-2-oxo-7-azaspiro[3.5]nonane;2-Oxo-7-azaspiro[3.5]nonane-7-carboxyL;2-Oxo-7-Azaspiro[3.5]Nonane-7-Carboxylate;7-Azaspiro[3.5]nonan-2-one, N-BOC protected;7-tert-Butoxycarbonyl-7-azaspiro[3.5]nonan-2-one;2-Oxo-7-Azaspiro[3.5]Nonane-7-tert-Butyl formate
CBNumber:
CB92537657
Molecular Formula:
C13H21NO3
Molecular Weight:
239.31
MDL Number:
MFCD12198552
MOL File:
203661-69-2.mol
MSDS File:
SDS
Last updated:2026-05-28 05:43:42
Product description Number Pack Size Price
2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester AldrichCPR SYX00121 1g $32.7
tert-Butyl 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate min. 97.0 % D6549 5G $66
tert-Butyl 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate TRC-B809638-5G 5g $154
tert-Butyl 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate TRC-B809638-500MG 500mg $97
tert-Butyl 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate TRC-B809638-1G 1g $123
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tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Properties

Melting point 55-56℃
Boiling point 349℃
Density 1.12
Flash point 165℃
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form solid
pka -0.80±0.20(Predicted)
color Clear yellow
InChI InChI=1S/C13H21NO3/c1-12(2,3)17-11(16)14-6-4-13(5-7-14)8-10(15)9-13/h4-9H2,1-3H3
InChIKey SIMIIXFMGJYGLR-UHFFFAOYSA-N
SMILES C1C2(CCN(C(OC(C)(C)C)=O)CC2)CC1=O
UNSPSC Code 12352108
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P280
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  WGK 3
HS Code  29339900
Storage Class 11 - Combustible Solids

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SYX00121 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester AldrichCPR 203661-69-2 1g $32.7 2026-04-30 Buy
TCI Chemical D6549 tert-Butyl 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate min. 97.0 % 203661-69-2 5G $66 2026-04-30 Buy
TRC TRC-B809638-5G tert-Butyl 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate 203661-69-2 5g $154 2026-06-03 Buy
TRC TRC-B809638-500MG tert-Butyl 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate 203661-69-2 500mg $97 2026-06-03 Buy
TRC TRC-B809638-1G tert-Butyl 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate 203661-69-2 1g $123 2026-06-03 Buy
Product number Packaging Price Buy
SYX00121 1g $32.7 Buy
D6549 5G $66 Buy
TRC-B809638-5G 5g $154 Buy
TRC-B809638-500MG 500mg $97 Buy
TRC-B809638-1G 1g $123 Buy

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Chemical Properties,Uses,Production

Uses

2-O-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester is an organic intermediate commonly used in drug design. It has been reported in the literature to be used in the preparation of compound 2-[2,6-difluoro-4-(4-methanesulfonylphenyl)phenoxy]-7-azaspirocyclic[3.5]nonane-7-carboxylic acid tert-butyl ester, a GPR119 agonist used to treat diseases such as diabetes and metabolic disorders.

Chemical Properties

White powder

Synthesis

To a flame-dried RB flask with tert-butyl 4-methylenepiperidine-1- carboxylate (2.96 g, 15 mmol, 1.0 equiv) and Zn/Cu couple (6.54 g, 172.5 mmol, 11.5 equiv) under vacuum, t-BuOMe (60 mL) was charged and refilled the flask with N2 balloon. To the mixture thus obtained stirred at 15 °C, a solution of 2,2,2- trichloroacetyl chloride in DME (20 mL) was added dropwise. The mixture was stirred at room temperature overnight after addition. To the reaction mixture stirred in an external ice- bath, a saturated solution of NH4CI (60 mL) was added slowly and carefully (especially the first few drops). After addition, the mixture was stirred at room temperature for 4 h and filtered to remove the solid. The phases were separated. The aqueous phase was extracted with EtOAc. The combined organic phase was washed with brine, dried over anhydrous Na2S04, and concentrated to give the residue, which was purified by CombiFlash (40 g silica gel column, EtOAc/Hexane: 0-40percent) to afford 619 mg (15%) of tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate.

References

[1] Patent: CN106674112, 2017, A. Location in patent: Paragraph 0037-0038
[2] Patent: WO2013/13308, 2013, A1. Location in patent: Paragraph 00199-00201

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate synthesis

396653-31-9
203661-69-2
Synthesis of tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate from tert-butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Preparation Products And Raw materials

Raw materials

tert-Butyl 4-methylenepiperidine-1-carboxylate tert-butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Trichloroacetyl chloride tert-Butyl methyl ether

Preparation Products

tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate 7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-(aminomethyl)-, 1,1-dimethylethyl ester 7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-amino-, 1,1-dimethylethyl ester 7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-hydroxy-, 1,1-dimethylethyl ester 7-Aza-spiro[3.5]nonane

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Suppliers

Global( 177)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14026 58
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Jinan Liheng Biotechnology Co., Ltd. 		15865262812 info@lihengpharm.com CHINA 938 58
ENBRIDGE PHARMTECH CO., LTD. 		+8613812269233 tinayang@enbridgepharm.com China 308 58
Supplier Advantage
Shanghai Daken Advanced Materials Co.,Ltd 		58
Hi-Tech Chemistry Corp 		58
ATK CHEMICAL COMPANY LIMITED 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
career henan chemical co 		58
Jinan Liheng Biotechnology Co., Ltd. 		58
ENBRIDGE PHARMTECH CO., LTD. 		58

View Lastest Price from tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate pictures 2026-07-24 tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
203661-69-2
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate pictures 2026-07-06 tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
203661-69-2
 $125.00-650.00 5g 99% 30 Zibo Hangyu Biotechnology Development Co., Ltd
tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate pictures 2025-04-04 tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate
203661-69-2
 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate Spectrum

tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate(203661-69-2)1HNMR

203661-69-2(tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate)Related Search:

2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate tert-butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate hydrochloride tert-butyl 4-(6-aMinopyridin-3-yl)piperidine-1-carboxylate tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate 5-Amino-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester
tert-butyl (S)-(1-(3-aminophenyl)ethyl)carbamate tert-butyl-trans-3,4-dihydroxypyrrolidine-1-carboxylate tert-butyl 5-methoxyhexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE tert-butyl 4-(azetidin-3-yl)piperidine-1-carboxylate
(3R,4S)-tert-butyl 3,4-dihydroxypyrrolidine-1-carboxylate N-BOC-3A,4,7,7A-TETRAHYDROISOINDOLE tert-butyl 6-oxooctahydro-2H-cyclopenta[c]pyridine-2-carboxylate tert-Butyl 2,6-diazaspiro[3.5]nonane-6-carboxylate tert-butyl 3-bromo-2,5-dihydro-1H-pyrrole-1-carboxylate
tert-Butyl 4-(pyrrolidin-3-yl)piperidine-1-carboxylate Carbamic acid, [(1S,3R)-3-hydroxycyclopentyl]-, 1,1-dimethylethyl ester (9CI) tert-butyl 6-hydroxy-3-azabicyclo[3.1.0]hexane-3-carboxylate

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7-Boc-2-oxo-7-azaspiro[3.... 7-Boc-2-oxo-7-azaspiro[3.5]nonane 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate 7-tert-Butoxycarbonyl-7-azaspiro[3.5]nonan-2-one 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester 7-Azaspiro[3.5]nonane-7-carboxylic acid, 2-oxo-, 1,1-dimethylethyl ester 7-Azaspiro[3.5]nonan-2-one, N-BOC protected N-Boc-2-oxo-7-azaspiro[3.5]nonane ert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate 2-Oxo-7-aza-spiro3.5none-7-carboxylic acid tert-butyl ester 2-Oxo-7-azaspiro[3.5]nonane-7-carboxyL ate tert-butyL 1,1-Dimethylethyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate 2-oxo-7-azaspiro[3,5]nonane-7-carboxylic tertbytyl ester 2-Oxo-7-Azaspiro[3.5]Nonane-7-Carboxylate tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate 97% 2-Oxo-7-azaspiro[3.5]nonane-7-carboxylate tert-butyl ester - [X1497] 2-Oxo-7-Azaspiro[3.5]Nonane-7-tert-Butyl formate 203661-69-2 6203661-69-2 03661-69-2 203661-89-2