tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate
![tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate Structure](CAS/GIF/1250994-14-9.gif)
- CAS No.
- 1250994-14-9
- Chemical Name:
- tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate
- Synonyms
- tert-butyl 3-oxo-8-azaspiro[4.5]decane-8-carboxylate;1,1-Dimethylethyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate;8-Boc-8-azaspiro[4.5]decan-2-one;1-Boc-2-oxo-8-azaspiro-[4.5]decane-8-carboxylic acid;tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate;1-Boc-2-oxo-8-azaspiro[4.5]decane-8-carboxylic acid - [X13487];2-OXO-8-AZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER;8-Azaspiro[4.5]decane-8-carboxylic acid, 2-oxo-, 1,1-dimethylethyl ester
- CBNumber:
- CB93033008
- Molecular Formula:
- C14H23NO3
- Molecular Weight:
- 253.34
- MDL Number:
- MFCD18792443
- MOL File:
- 1250994-14-9.mol
- MSDS File:
- SDS
| Boiling point | 365.0±35.0 °C(Predicted) |
|---|---|
| Density | 1.10±0.1 g/cm3(Predicted) |
| storage temp. | Storage temp. 2-8°C |
| pka | -0.77±0.20(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C14H23NO3/c1-13(2,3)18-12(17)15-8-6-14(7-9-15)5-4-11(16)10-14/h4-10H2,1-3H3 |
| InChIKey | ZXXJXEXKMUZKPG-UHFFFAOYSA-N |
| SMILES | C1C2(CCN(C(OC(C)(C)C)=O)CC2)CCC1=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | AAC99414 | 8-Boc-8-azaspiro[4.5]decan-2-one | 1250994-14-9 | 100mg | $318 | 2026-06-04 | Buy |
| Biosynth | AAC99414 | 8-Boc-8-azaspiro[4.5]decan-2-one | 1250994-14-9 | 1g | $800 | 2026-06-04 | Buy |
| Matrix Scientific | 123518 | 1-Boc-2-oxo-8-azaspiro-[4.5]decane-8-carboxylic acid | 1250994-14-9 | 100.00mg | $83 | 2026-05-18 | Buy |
| Matrix Scientific | 123518 | 1-Boc-2-oxo-8-azaspiro-[4.5]decane-8-carboxylic acid | 1250994-14-9 | 250.00mg | $112 | 2026-05-18 | Buy |
| Matrix Scientific | 123518 | 1-Boc-2-oxo-8-azaspiro-[4.5]decane-8-carboxylic acid | 1250994-14-9 | 1.00g | $361 | 2026-05-18 | Buy |
tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate Chemical Properties,Uses,Production
Uses
tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate is a useful research chemical.
Synthesis
80-11-5
![tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate](/CAS/GIF/203661-69-2.gif)
203661-69-2
![tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate](/CAS/GIF/1250994-14-9.gif)
1250994-14-9
A 10% to 40% aqueous solution of potassium hydroxide (20 mL) was added to a solvent mixture of tetrahydrofuran and methanol containing tert-butyl-2-oxo-7-azaspiro[3.5]nonane-7-carboxylic acid (8.2 g). The solvent ratio was 10:1. In another vessel, N-methyl-N-nitroso-p-toluenesulfonamide (19.6 g) was dissolved in 300 mL of water and added slowly and dropwise at 0 °C to the above reaction solution. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the system was cooled to room temperature and the reaction was quenched by the addition of acetic acid. Subsequently, the reaction mixture was rotary evaporated to dryness and the residue was dissolved in ethyl acetate (100 mL) and washed sequentially with water (100 mL) and saturated brine (100 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification by column chromatography afforded ethyl tert-butyl-2-oxo-8-azaspiro[4.5]decane-8-carboxylate (6.6 g, yield: 72%).
References
[1] Patent: CN105272914, 2016, A. Location in patent: Paragraph 0010; 0014
tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate Preparation Products And Raw materials
tert-butyl 2-oxo-8-azaspiro[4.5]decane-8-carboxylate Suppliers
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