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Methyl 2-(3-cyanopyridin-4-yl)acetate

Methyl 2-(3-cyanopyridin-4-yl)acetate Structure
Methyl 2-(3-cyanopyridin-4-yl)acetate structure
CAS No.
124870-33-3
Chemical Name:
Methyl 2-(3-cyanopyridin-4-yl)acetate
Synonyms
Methyl 2-(3-cyanopyridin-4-yl);Methyl 2-(3-Cyano-4-pyridyl)acetate;Methyl 2-(3-cyanopyridin-4-yl)acetate;4-Pyridineacetic acid, 3-cyano-, methyl ester;(3-Cyano-pyridin-4-yl)-acetic acid Methyl ester
CBNumber:
CB92604186
Molecular Formula:
C9H8N2O2
Molecular Weight:
176.17
MDL Number:
MFCD11847770
MOL File:
124870-33-3.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:42
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Methyl 2-(3-cyanopyridin-4-yl)acetate Properties

Boiling point 295.5±25.0 °C(Predicted)
Density 1.21±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 1.78±0.18(Predicted)
Appearance Yellow to orange Liquid

Methyl 2-(3-cyanopyridin-4-yl)acetate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS43014 Methyl 2-(3-cyanopyridin-4-yl)acetate 97% 124870-33-3 1g $202 2026-06-04 Buy
Activate Scientific AS43014 Methyl 2-(3-cyanopyridin-4-yl)acetate 97% 124870-33-3 5g $909 2026-06-04 Buy
Synthonix M51393 Methyl 2-(3-cyanopyridin-4-yl)acetate 97% 124870-33-3 100mg $64 2026-05-06 Buy
Synthonix M51393 Methyl 2-(3-cyanopyridin-4-yl)acetate 97% 124870-33-3 250mg $70 2026-05-06 Buy
Synthonix M51393 Methyl 2-(3-cyanopyridin-4-yl)acetate 97% 124870-33-3 1g $190 2026-05-06 Buy
Product number Packaging Price Buy
AS43014 1g $202 Buy
AS43014 5g $909 Buy
M51393 100mg $64 Buy
M51393 250mg $70 Buy
M51393 1g $190 Buy

Methyl 2-(3-cyanopyridin-4-yl)acetate Chemical Properties, Uses, Production

Synthesis

3-Cyano-4-methylpyridine

5444-01-9

Dimethyl carbonate

616-38-6

Methyl 2-(3-cyanopyridin-4-yl)acetate

124870-33-3

Preparation of the intermediate 2-(3-cyanopyridin-4-yl)acetic acid methyl ester (I-65a): in a dry reaction flask, 4-methylnicotinonitrile (2.52 g, 21.33 mmol) was dissolved in anhydrous THF (15 mL) and cooled to -78 °C. A THF solution of 1 M LiHMDS (45 mL, 44.794 mmol) was slowly added under nitrogen protection, kept at -78 °C and stirred for 1 hour. Subsequently, dimethyl carbonate (1.98 mL, 23.464 mmol) was added dropwise to the reaction system and stirring was continued at -78 °C for 1 h. The temperature was then slowly raised to 0 °C and stirred for 2 h. The reaction was carried out by TLC. The progress of the reaction was monitored by TLC (unfolding agent: hexane solution of 30% ethyl acetate). Upon completion of the reaction, the reaction was quenched with saturated NH4Cl solution and then extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane solution of 25% ethyl acetate) to give 530 mg of the target product in 14.10% yield. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 8.9 (s, 1H), 8.79 (d, 1H), 7.4 (d, 1H), 3.9 (s, 2H), 3.79 (s, 3H).

References

[1] Patent: WO2012/35078, 2012, A1. Location in patent: Page/Page column 156-157
[2] Patent: US2014/45872, 2014, A1. Location in patent: Paragraph 0970

Methyl 2-(3-cyanopyridin-4-yl)acetate synthesis

616-38-6
124870-33-3
Synthesis of Methyl 2-(3-cyanopyridin-4-yl)acetate from Dimethyl carbonate

Methyl 2-(3-cyanopyridin-4-yl)acetate Preparation Products And Raw materials

Raw materials

3-Cyano-4-methylpyridine 3-Cyanopyridine Dimethyl carbonate Tetrahydrofuran Lithium bis(trimethylsilyl)amide

Preparation Products

Methyl 2-(3-cyanopyridin-4-yl)acetate Suppliers

Global Suppliers ( 31)
Supplier Tel Email Country ProdList Advantage
Wuhan ariel chemical Co., LTD. 18986259541 18986259541 sales@3stc.com China 3827 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
SynAsst Chemical. 021-60343070 China 12731 55
Wuhan Kaymke Chemical Co., Ltd., 027-87342388 18086026008 sales@kaymke.com China 3537 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Shanghai PharmaPartner Co., Ltd. 19983777532 pharmabridge@163.com China 500 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Jiaxing Deyi Chemical Co., Ltd. 86-0573-85866609 18367600069 945717149@qq.com China 9507 58
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
Supplier Advantage
Wuhan ariel chemical Co., LTD. 58
Nanjing Norris-Pharm Technology Co., Ltd 55
SynAsst Chemical. 55
Wuhan Kaymke Chemical Co., Ltd., 55
Bide Pharmatech Ltd. 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
Shanghai PharmaPartner Co., Ltd. 55
Amadis Chemical Company Limited 58
Jiaxing Deyi Chemical Co., Ltd. 58
Aikon International Limited 58

View Latest Price from Methyl 2-(3-cyanopyridin-4-yl)acetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl 2-(3-cyanopyridin-4-yl)acetate pictures 2020-01-09 Methyl 2-(3-cyanopyridin-4-yl)acetate
124870-33-3
 $1.00 1KG 95%-99% 1ton Career Henan Chemical Co

Methyl 2-(3-cyanopyridin-4-yl)acetate Spectrum

Methyl 2-(3-cyanopyridin-4-yl)acetate(124870-33-3)1HNMR

124870-33-3 (Methyl 2-(3-cyanopyridin-4-yl)acetate) Related Search:

methyl 2-(2,6-dichloro-3-cyanopyridin-4-yl)acetate Ethyl 3-methylpyridine-4-acetate 4-(2-hydroxyethyl)-3-Pyridinecarbonitrile Ethyl 2-(3-cyanopyridin-4-yl)acetate 2-(3-Cyanopyridin-4-yl)acetic acid
3-Pyridineacetic acid, 4-cyano-, methyl ester

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Methyl 2-(3-cyanopyridin-4-yl)acetate (3-Cyano-pyridin-4-yl)-acetic acid Methyl ester Methyl 2-(3-cyanopyridin-4-yl) 4-Pyridineacetic acid, 3-cyano-, methyl ester Methyl 2-(3-Cyano-4-pyridyl)acetate 124870-33-3