Indotecan
- CAS No.
- 915303-09-2
- Chemical Name:
- Indotecan
- Synonyms
- LMP-400);Indotecan;NSC-724998;Indotecan (LMP400);FMFIFGLHVOZDEL-UHFFFAOYSA-N;LMP400; LMP-400; LMP 400; INDOTECAN;LMP400,inhibit,NSC 724998,Inhibitor,Indotecan,Topoisomerase,NSC724998,LMP 400;2,3-Dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione;2,3-Dimethoxy-6-(3-morpholinopropyl)-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione;5H-[1,3]Dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione, 2,3-dimethoxy-6-[3-(4-morpholinyl)propyl]-
- CBNumber:
- CB92668485
- Molecular Formula:
- C26H26N2O7
- Molecular Weight:
- 478.49
- MDL Number:
- MFCD25977124
- MOL File:
- 915303-09-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Indotecan 98.0% | CS-0007476 | 1mg | $87 |
| Indotecan 98.0% | CS-0007476 | 5mg | $173 |
| Indotecan 98.0% | CS-0007476 | 10mg | $277 |
| Indotecan 98.0% | CS-0007476 | 25mg | $487 |
| Indotecan 98.0% | CS-0007476 | 50mg | $780 |
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| form | Solid |
| color | White to gray |
| NCI Dictionary of Cancer Terms | LMP400 |
| FDA UNII | BTA69L5M8D |
Indotecan price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0007476 | Indotecan 98.0% | 915303-09-2 | 1mg | $87 | 2026-06-04 | Buy |
| ChemScene | CS-0007476 | Indotecan 98.0% | 915303-09-2 | 5mg | $173 | 2026-06-04 | Buy |
| ChemScene | CS-0007476 | Indotecan 98.0% | 915303-09-2 | 10mg | $277 | 2026-06-04 | Buy |
| ChemScene | CS-0007476 | Indotecan 98.0% | 915303-09-2 | 25mg | $487 | 2026-06-04 | Buy |
| ChemScene | CS-0007476 | Indotecan 98.0% | 915303-09-2 | 50mg | $780 | 2026-06-04 | Buy |
Indotecan Chemical Properties,Uses,Production
Uses
Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis[1][2].
in vivo
Indotecan (2.5 mg/kg; i.p. every 2 d for 15 d) depletes the parasitic burden in the spleen and liver of visceral leishmaniasis mice[2].
| Animal Model: | Female BALB/c mice (4-6 weeks) were infected with metacyclic parasites intravenously through the tail vein[2] |
| Dosage: | 2.5 mg/kg body weight per injection |
| Administration: | Intraperitoneally every 2 days for 15 days (total, eight doses) |
| Result: | A drastic reduction of the number of transforming amastigotes recovered from the target organs of drug-treated animals was observed. |
IC 50
Topoisomerase I
References
[1] Balaa-Fouce R, et, al. Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis. Antimicrob Agents Chemother. 2012 Oct;56(10):5264-70. DOI:10.1128/AAC.00499-12
[2] Seol Y, et, al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9. DOI:10.1158/1535-7163.MCT-15-0454
Indotecan Preparation Products And Raw materials
Raw materials
Preparation Products
Indotecan Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4854 | 55 | |
| Suzhou Ran enzyme Biotechnology Co., Ltd. | 0512-0512-62793604 18015430729 | 116667374@qq.com | China | 132 | 58 |
| Zhengzhou Acme Chemical Co., Ltd. | 0371-63315541 13323832564 | 1443871971@qq.com | China | 9901 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
