| Identification | Back Directory | [Name]
Indotecan | [CAS]
915303-09-2 | [Synonyms]
LMP-400)
Indotecan
NSC-724998
Indotecan (LMP400)
FMFIFGLHVOZDEL-UHFFFAOYSA-N
LMP400; LMP-400; LMP 400; INDOTECAN
5H-[1,3]Dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione, 2,3-dimethoxy-6-[3-(4-morpholinyl)propyl]- | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C26H26N2O7 | [MDL Number]
MFCD25977124 | [MOL File]
915303-09-2.mol | [Molecular Weight]
478.49 |
| Hazard Information | Back Directory | [Uses]
Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis[1][2]. | [in vivo]
Indotecan (2.5 mg/kg; i.p. every 2 d for 15 d) depletes the parasitic burden in the spleen and liver of visceral leishmaniasis mice[2]. | Animal Model: | Female BALB/c mice (4-6 weeks) were infected with metacyclic parasites intravenously through the tail vein[2] | | Dosage: | 2.5 mg/kg body weight per injection | | Administration: | Intraperitoneally every 2 days for 15 days (total, eight doses) | | Result: | A drastic reduction of the number of transforming amastigotes recovered from the target organs of drug-treated animals was observed. |
| [IC 50]
Topoisomerase I | [References]
[1] Bala?a-Fouce R, et, al. Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis. Antimicrob Agents Chemother. 2012 Oct;56(10):5264-70. DOI:10.1128/AAC.00499-12
[2] Seol Y, et, al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9. DOI:10.1158/1535-7163.MCT-15-0454 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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