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ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE structure

CAS No.: 64067-99-8

Chemical Name:: ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE

Synonyms: Ethyl 6-Chloroimidazo[1,2-b]pyridazine-2-;ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYATE;ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE;Ethyl 6-Chloroimidazo[1,2-β]pyridazine-2-carboxylate;ethyl 6-chloroimidazo[2,1-f][1,2]diazine-2-carboxylate;methyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate ;6-Chloroimidazo[1,2-β]pyridazine-2-carboxylic Acid Ethyl Ester;6-Chloroimidazo[1,2-b]pyridazine-2-carboxylic Acid Ethyl Ester;ethyl 6-chloro-1,5-dihydroiMidazo[1,2-b]pyridazine-2-carboxylate;Imidazo[1,2-b]pyridazine-2-carboxylic acid, 6-chloro-, ethyl ester

CBNumber:: CB9266900

Molecular Formula:: C9H8ClN3O2

Molecular Weight:: 225.63

MDL Number:: MFCD03086230

MOL File:: 64067-99-8.mol

Last updated:2025-07-24 18:13:53

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ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE Properties

Melting point	155-158
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform, Dichloromethane, Ethyl Acetate, Methanol
form	Solid
pka	0.17±0.30(Predicted)
color	Brown
InChI	InChI=1S/C9H8ClN3O2/c1-2-15-9(14)6-5-13-8(11-6)4-3-7(10)12-13/h3-5H,2H2,1H3
InChIKey	AZEPEWATPYRPBM-UHFFFAOYSA-N
SMILES	C12=NC(C(OCC)=O)=CN1N=C(Cl)C=C2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes	Xi
HazardClass	IRRITANT
HS Code	2933998090

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	E901920	Ethyl6-Chloroimidazo[1,2-b]pyridazine-2-carboxylate	64067-99-8	500mg	$75	2021-12-16	Buy
Usbiological	011574	Ethyl 6-Chloroimidazo[1,2-b]pyridazine-2-carboxylate	64067-99-8	1g	$425	2021-12-16	Buy
TRC	E901920	Ethyl6-Chloroimidazo[1,2-b]pyridazine-2-carboxylate	64067-99-8	5g	$570	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0026089	ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE 95.00%	64067-99-8	250MG	$647.36	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0026089	ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE 95.00%	64067-99-8	1G	$699.74	2021-12-16	Buy

Product number	Packaging	Price	Buy
E901920	500mg	$75	Buy
011574	1g	$425	Buy
E901920	5g	$570	Buy
HCH0026089	250MG	$647.36	Buy
HCH0026089	1G	$699.74	Buy

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE Chemical Properties,Uses,Production

Chemical Properties

Brown Solid

Uses

Anti-inflammatory agent.

Synthesis

5469-69-2

70-23-5

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE

64067-99-8

To a suspension of 6-chloropyridazin-3-amine (10.00 g, 77 mmol) in ethanol (30 mL) at 0 °C, a solution of ethyl 3-bromo-2-oxopropanoate (20.07 g, 93 mmol) in ethanol (5 mL) was slowly added by pipette. After addition, the ice bath was removed and the reaction mixture was stirred at room temperature for 15 min, followed by warming to 80 °C for 30 min. After 2 hours of reaction, the mixture was cooled to room temperature and the precipitated beige solid was collected by vacuum filtration and washed with cold ethanol. The resulting solid was suspended in saturated aqueous NaHCO3 solution and stirred for 30 minutes. The solid was again collected by vacuum filtration and the filter cake was washed with water, dried over a filter and further dried under vacuum to give ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate as a brown solid (8.8 g, 39.0 mmol, 51% yield). The product was characterized by NMR (400 MHz, chloroform-d3): δ 8.46 (s, 1H), 8.13 (d, J=9.5 Hz, 1H), 7.23 (d, J=9.5 Hz, 1H), 4.49 (q, J=7.2 Hz, 2H), 1.46 (t, J=7.1 Hz, 3H). the LC retention time was 2.29 min (Analytical HPLC method A). LC/MS showed (M+H)+ peaks of 226/228 (ratio about 3:1).

References

[1] Patent: WO2016/149437, 2016, A1. Location in patent: Page/Page column 58
[2] Journal of Pharmacology and Experimental Therapeutics, 2018, vol. 364, # 2, p. 246 - 257
[3] Patent: WO2016/97347, 2016, A1. Location in patent: Page/Page column 149
[4] Patent: WO2016/97359, 2016, A1. Location in patent: Page/Page column 125
[5] Farmaco, 1997, vol. 52, # 4, p. 213 - 217

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

6-Chloropyridazin-3-amine Ethyl bromopyruvate

Preparation Products

6-Methoxy-iMidazo[1,2-b]pyridazine-2-carboxylic acid 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)propan-2-ol

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE Suppliers

Global( 147)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29800	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Shanghai Rlavie Technology Co ltd	+86-021-67759270 +8617717059219	sales@rlavie.com	China	1030	58
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; +8619817745290	bd@blocksynth.com	China	5661	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Shanghai Rlavie Technology Co ltd	58
Blocksynth Pharmaceutical Technology Co.,Ltd	58

View Lastest Price from ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-01-04	6-Chloroimidazo[1,2-b]pyridazine-2-carboxylicacid ethyl ester 64067-99-8	US $0.00-0.00 / KG	1g	98%minHPLC	50kgs/month	Shanghai Rlavie Technology Co ltd
2021-11-03	ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE 64067-99-8	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2019-12-20	ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE 64067-99-8	US $1.00 / KG	1KG	99%	KG/T	Career Henan Chemical Co

6-Chloroimidazo[1,2-b]pyridazine-2-carboxylicacid ethyl ester
64067-99-8
US $0.00-0.00 / KG
98%minHPLC
Shanghai Rlavie Technology Co ltd

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE
64067-99-8
US $1.10 / g
99.00%
Dideu Industries Group Limited

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE
64067-99-8
US $1.00 / KG
99%
Career Henan Chemical Co

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE Spectrum

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE(64067-99-8)¹HNMR

64067-99-8(ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE)Related Search:

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ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE Ethyl 6-Chloroimidazo[1,2-b]pyridazine-2- ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYATE 6-Chloroimidazo[1,2-β]pyridazine-2-carboxylic Acid Ethyl Ester Ethyl 6-Chloroimidazo[1,2-β]pyridazine-2-carboxylate methyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate 6-Chloroimidazo[1,2-b]pyridazine-2-carboxylic Acid Ethyl Ester ethyl 6-chloro-1,5-dihydroiMidazo[1,2-b]pyridazine-2-carboxylate Imidazo[1,2-b]pyridazine-2-carboxylic acid, 6-chloro-, ethyl ester ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE ISO 9001：2015 REACH ethyl 6-chloroimidazo[2,1-f][1,2]diazine-2-carboxylate 64067-99-8 Bases & Related Reagents Heterocycles Intermediates Nucleotides Heterocyclic Compounds blocks Carboxes Imidazoles Pyridines