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4-Phenoxyphenylboronic acid

4-Phenoxyphenylboronic acid Structure
4-Phenoxyphenylboronic acid structure
CAS No.
51067-38-0
Chemical Name:
4-Phenoxyphenylboronic acid
Synonyms
4-PHENOXYPHENYLBORONIC;EOS-61617;AKOS BRN-0132;RARECHEM AH PB 0260;TIMTEC-BB SBB003409;Ibrutinib Impurity 36;4-PHENOXYPHENYLBORONI;4-Boronodiphenyl ether;4-phenoxy-phenylboric acid;4-Phenoxyphenylboronic acid
CBNumber:
CB9278200
Molecular Formula:
C12H11BO3
Molecular Weight:
214.02
MDL Number:
MFCD00093312
MOL File:
51067-38-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:56:20
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4-Phenoxyphenylboronic acid Properties

Melting point 141-145 °C(lit.)
Boiling point 377.0±44.0 °C(Predicted)
Density 1.23±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
pka 8.76±0.10(Predicted)
form Crystalline Powder
color White to beige
InChI InChI=1S/C12H11BO3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9,14-15H
InChIKey KFXUHRXGLWUOJT-UHFFFAOYSA-N
SMILES B(C1=CC=C(OC2=CC=CC=C2)C=C1)(O)O
CAS DataBase Reference 51067-38-0(CAS DataBase Reference)
UNSPSC Code 12352103
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26
WGK Germany  3
HazardClass  IRRITANT
HS Code  29319090
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
0
2 0

4-Phenoxyphenylboronic acid price More Price(84)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 480142 4-Phenoxyphenylboronic acid ≥95.0% 51067-38-0 5g $89.9 2026-04-30 Buy
Sigma-Aldrich 480142 4-Phenoxyphenylboronic acid ≥95.0% 51067-38-0 25g $363 2023-06-20 Buy
TCI Chemical P1974 4-Phenoxyphenylboronic Acid (contains varying amounts of Anhydride) 51067-38-0 5g $49 2026-04-30 Buy
TCI Chemical P1974 4-Phenoxyphenylboronic Acid (contains varying amounts of Anhydride) 51067-38-0 25g $144 2026-04-30 Buy
Usbiological 433353 4-Phenoxybenzeneboronic Acid 51067-38-0 1g $326 2026-06-03 Buy
Product number Packaging Price Buy
480142 5g $89.9 Buy
480142 25g $363 Buy
P1974 5g $49 Buy
P1974 25g $144 Buy
433353 1g $326 Buy

4-Phenoxyphenylboronic acid Chemical Properties, Uses, Production

Chemical Properties

white to off-white powder and chunk

Uses

suzuki reaction

Uses

4-Phenoxybenzeneboronic Acid is an intermediate used to prepare biphenyl derivatives of nitotrifluoromethoxybenzyloxydihydroimidazooxazines with antitubercular activity. It is also used in the synthesis of pyrrolo pyrimidines as potent inhibitors of Lck kinase.

Uses

4-Phenoxyphenylboronic acid can be used as a reactant:

  • In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst.
  • To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions.
  • To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.

Synthesis

4-Bromodiphenyl ether (100 g, 0.402 mol)Was dissolved in anhydrous THF (800 mL)Under nitrogen protection,Cooled to -78 ° C,N-butyllithium (n-BuLi) (177 mL, 0.442 mol)The temperature is kept below -65 ° C,After stirring for 1 h,Continue to maintain the temperature -60 ,Triisopropyl borate (90 g, 0.482 mol) was added dropwise,Slowly rose to 0 ° C, stir for 3 h.Water (300 mL) was added under ice bath overnight. The reaction solution was concentrated to remove the organic phase,With 12N concentrated hydrochloric acid pH adjusted to 1 ~ 2,Precipitation of solids,Filtration and drying gave 4-phenoxyphenylboronic acid (77 g, yield 90%).

References

[1] Patent: CN106146511, 2016, A. Location in patent: Paragraph 0147; 0148; 0149
[2] Organic Process Research and Development, 2018, vol. 22, # 6, p. 741 - 746
[3] Patent: US2002/156081, 2002, A1
[4] Patent: US6921763, 2005, B2

4-Phenoxyphenylboronic acid synthesis

5419-55-6
2050-47-7
7732-18-5
51067-38-0
Synthesis of 4-Phenoxyphenylboronic acid from Triisopropyl borate and Bis(4-bromophenyl) ether and Water

4-Phenoxyphenylboronic acid Preparation Products And Raw materials

Raw materials

4-Bromophenoxybenzene Trimethyl borate Tetrahydrofuran n-Butyllithium 2-Bromodiphenyl ether
Triisopropyl borate Water

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Preparation Products

4-(Trifluoromethyl)diphenyl ether 4-Nitrophenyl phenyl ether 4-Phenoxyphenol Benzene, 1-bromo-2-fluoro-4-phenoxy- 3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine
1-Phenoxy-4-(2-propenyl)benzene

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4-Phenoxyphenylboronic acid Suppliers

Global Suppliers ( 416)
Supplier Tel Email Country ProdList Advantage
China Synchem Technology Co.,Ltd. +86-0552-4929304 +86-18055277008 sales@cnsynchem.com China 55 65
Hebei Maison Chemical Co.,Ltd. 155-11852758; 18408670720 ruby@maisonchem.com.cn China 687 58
Cangzhou Dafeng Chemical Co., Ltd 18112498720 dfhxchemical@163.com China 27 58
Zhuhai Aobokai Biomedical Technology Co., Ltd. 400-0628126 sales-team@aobchem.com.cn China 49995 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Supplier Advantage
China Synchem Technology Co.,Ltd. 65
Hebei Maison Chemical Co.,Ltd. 58
Cangzhou Dafeng Chemical Co., Ltd 58
Zhuhai Aobokai Biomedical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65

View Latest Price from 4-Phenoxyphenylboronic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-PHENOXYPHENYLBORONIC ACID pictures 2026-09-02 4-PHENOXYPHENYLBORONIC ACID
51067-38-0
 $1.20-34.00 1kg 99% Henan Fengda Chemical Co., Ltd
4-PHENOXYPHENYLBORONIC ACID pictures 2026-06-30 4-PHENOXYPHENYLBORONIC ACID
51067-38-0
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
4-PHENOXYPHENYLBORONIC ACID pictures 2026-05-28 4-PHENOXYPHENYLBORONIC ACID
51067-38-0
 $9.00 1KG 99.9 1 ton Hebei Chuanghai Biotechnology Co,.LTD

4-Phenoxyphenylboronic acid Spectrum

4-PHENOXYPHENYLBORONIC ACID(51067-38-0)1HNMR4-PHENOXYPHENYLBORONIC ACID(51067-38-0)IR

51067-38-0 (4-Phenoxyphenylboronic acid) Related Search:

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4-PHENOXYBENZENEBORONIC ACID AKOS BRN-0132 RARECHEM AH PB 0260 (P-PHENOXYPHENYL)BORONIC ACID TIMTEC-BB SBB003409 4-Phenoxybenzeneboronic acid 98% 4-Phenoxyphenylboronic acid,97% 4-Phenoxyphenylboronic acid ,98% 4-Phenoxyphenylboronic Acid (contains varying aMounts of Anhydride) 4-Phenoxyphenylboronic acid, 97% 1GR EOS-61617 4-Phenoxyphenylboronic acid Ibrutinib 4-Boronodiphenyl ether 4-Phenoxyphenylboronic acid >=95.0% Ibrutinib Impurity 36 4-Phenoxyphenylboronic acid, 98%, for synthesis Boronic acid, B-(4-phenoxyphenyl)- 4-PHENOXYPHENYLBORONI 4-phenoxy-phenylboric acid 4-Phenoxyphenylboronic acid - [P4960] 4-PHENOXYPHENYLBORONIC 4-Phenoxyphenylboronic acid 51067-38-0 C12H11BO3 Aryl Boronic Acids Boronic Acids and Derivatives Organometallic Reagents blocks BoronicAcids Heterocyclic Compounds Aryl Organoborons Boronic Acids Boronic Acids and Derivatives Boronic Acids