Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>4-(Hydroxymethyl)phenylboronic acid

4-(Hydroxymethyl)phenylboronic acid

4-(Hydroxymethyl)phenylboronic acid Structure
4-(Hydroxymethyl)phenylboronic acid structure
CAS No.
59016-93-2
Chemical Name:
4-(Hydroxymethyl)phenylboronic acid
Synonyms
AKOS BRN-0115;RARECHEM AH PB 0190;4-Boronobenzyl alcohol;(4-Boronophenyl)methanol;4-(Hydroxymethyl)Phenylboronic;(4-methylolphenyl)boronic acid;4-HydroMethylphenylboronicacid;α-Hydroxy-p-tolueneboronic acid;4-(Hydroxymethyl)phenylboronicaci;(p-HydroxyMethyl)phenylboronic acid
CBNumber:
CB5296916
Molecular Formula:
C7H9BO3
Molecular Weight:
151.96
MDL Number:
MFCD00792672
MOL File:
59016-93-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:31:38
Request For Quotation

4-(Hydroxymethyl)phenylboronic acid Properties

Melting point 251-256 °C (lit.)
Boiling point 362.0±44.0 °C(Predicted)
Density 1.25±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Crystalline Powder
pka 8.53±0.10(Predicted)
color White to slightly yellow
PH 4.5 (10g/l, H2O)
Water Solubility 25 g/L
BRN 2831413
InChI InChI=1S/C7H9BO3/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4,9-11H,5H2
InChIKey PZRPBPMLSSNFOM-UHFFFAOYSA-N
SMILES B(C1=CC=C(CO)C=C1)(O)O
CAS DataBase Reference 59016-93-2(CAS DataBase Reference)
UNSPSC Code 12352103
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26-36
WGK Germany  3
HazardClass  IRRITANT
HS Code  29319090
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

4-(Hydroxymethyl)phenylboronic acid price More Price(91)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 512338 4-(Hydroxymethyl)phenylboronic acid ≥95% 59016-93-2 1g $44.7 2023-06-20 Buy
Sigma-Aldrich 512338 4-(Hydroxymethyl)phenylboronic acid ≥95% 59016-93-2 10g $45.3 2023-06-20 Buy
TCI Chemical H1204 4-(Hydroxymethyl)phenylboronic Acid (contains varying amounts of Anhydride) 59016-93-2 1g $48 2026-04-30 Buy
TCI Chemical H1204 4-(Hydroxymethyl)phenylboronic Acid (contains varying amounts of Anhydride) 59016-93-2 5g $145 2026-04-30 Buy
Usbiological 279961 4-(Hydroxymethyl)phenylboronic acid Asreported 59016-93-2 10g $333 2026-06-03 Buy
Product number Packaging Price Buy
512338 1g $44.7 Buy
512338 10g $45.3 Buy
H1204 1g $48 Buy
H1204 5g $145 Buy
279961 10g $333 Buy

4-(Hydroxymethyl)phenylboronic acid Chemical Properties, Uses, Production

Chemical Properties

Off-white Cryst

Uses

suzuki reaction

Uses

Reactant involved in the synthesis of biologically active compounds including:

  • Imidazo[4,5-b]pyrazin-2-ones for use as mTOR kinase inhibitors
  • Human immunodificiency virus protease inhibitors with activity against resistant viruses

Reactant involved in:
  • Suzuki coupling reactions
  • Copper-catalyzed transformation from arylboronic acids in water

Involved in the synthesis of polyurethane containing spindle-type chromophores

Synthesis

4-Formylphenylboronic acid

87199-17-5

4-(Hydroxymethyl)phenylboronic acid

59016-93-2

Sodium borohydride (0.38 g, 11 mmol) was added to a solution of (4-formylphenyl)boronic acid (1.5 g, 11 mmol) in methanol (40 mL) in batches at 0 °C, keeping the temperature at 0 °C and stirring the reaction mixture for 1 hour. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent to give the crude product. The crude product was dissolved in water, cooled to 0-5 °C, and the pH was adjusted to 5 by slowly adding 5% aqueous acetic acid.The precipitated solid was collected by diafiltration and washed with cold water, and dried to give 4-hydroxymethylphenylboronic acid (1.2 g, 80% yield). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 7.72 (d, J=7.2 Hz, 2H), 7.59 (d, J=7.6 Hz, 2H), 7.35-7.30 (m, 2H), 4.60 (s, 2H); Mass Spectrometry (ES+): m/z 542.15,544.35 [M+H]; LCMS retention time: tR = 2.42 min.

References

[1] Patent: WO2015/81280, 2015, A1. Location in patent: Paragraph 00689; 00698; 00699
[2] Patent: US5827887, 1998, A
[3] Dyes and Pigments, 2012, vol. 92, # 3, p. 982 - 987
[4] Organic and Biomolecular Chemistry, 2014, vol. 12, # 30, p. 5781 - 5788
[5] Patent: US6576789, 2003, B1

4-(Hydroxymethyl)phenylboronic acid Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid Nickel Tetrahydrofuran Ethylene glycol Triisopropyl borate
4-Bromobenzaldehyde n-Butyllithium 4-Formylphenylboronic acid Methanol Sodium borohydride

1of2

Preparation Products

GSK2190915 (sodiuM salt) 3-Iodobenzyl alcohol 4,4'-Bis(hydroxymethyl)biphenyl (4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol p-(phenylthio)benzyl alcohol
3-(5-Cyanopyridin-3-yl)benzyl alcohol [4-(1H-Imidazol-4-yl)-phenyl]-methanol 4-(3-Fluorophenyl)benzyl alcohol 4-(5-Fluoro-2-pyridinyl)benzeneMethanol 2-(3-Hydroxymethylphenyl)thiophene-3-carboxylic acid

1of2

4-(Hydroxymethyl)phenylboronic acid Suppliers

Global Suppliers ( 412)
Supplier Tel Email Country ProdList Advantage
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. 021-69106960 13701823997 13701823733@163.com China 4634 60
Suzhou You Boron Photoelectric Material Co., Ltd. 15301358979 37303017@qq.com China 494 58
Zhuhai Aobokai Biomedical Technology Co., Ltd. 400-0628126 sales-team@aobchem.com.cn China 49995 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. 60
Suzhou You Boron Photoelectric Material Co., Ltd. 58
Zhuhai Aobokai Biomedical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

View Latest Price from 4-(Hydroxymethyl)phenylboronic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(Hydroxymethyl)phenylboronic acid pictures 2026-09-02 4-(Hydroxymethyl)phenylboronic acid
59016-93-2
 $1.20-34.00 1kg 99% Henan Fengda Chemical Co., Ltd
4-(Hydroxymethyl)phenylboronic acid pictures 2025-05-23 4-(Hydroxymethyl)phenylboronic acid
59016-93-2
 $10.00 1kg 99% 20 ton Hebei Zhuanglai Chemical Trading Co Ltd
4-(Hydroxymethyl)phenylboronic acid pictures 2025-04-04 4-(Hydroxymethyl)phenylboronic acid
59016-93-2
 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.

4-(Hydroxymethyl)phenylboronic acid Spectrum

4-(Hydroxymethyl)phenylboronic acid(59016-93-2)1HNMR4-(Hydroxymethyl)phenylboronic acid(59016-93-2)IR

59016-93-2 (4-(Hydroxymethyl)phenylboronic acid) Related Search:

Methyl 2-hydroxyethyl cellulose CARBOXYMETHYLCELLULOSE SODIUM SALT methylol cellulose Phenylboronic acid 3,5-Dimethylphenylboronic acid
2-Hydroxyethyl methacrylate 4-Tolylboronic acid Trimethylolpropane Tris(hydroxymethyl)aminomethane 4-Carboxylphenylboronic acid pinacol ester
Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 3-Ethoxycarbonylphenylboronic acid 4-Carboxy-3-fluorophenylboronic acid (2-Amino-4-methoxycarbonylphenyl)boronic acid hydrochloride Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
(4-Benzyloxycarbonylphenyl)boronic acid 4-Isopropoxycarbonylphenylboronic acid 3,5-Difluoro-4-(hydroxymethyl)phenylboronic acid

1of4

α-Hydroxy-p-tolueneboronic acid (4-methylolphenyl)boronic acid 4-(HydroxyMethyl)phenylboronic acid, 95+% 4-(HYDROXYMETHYL)PHENYLBORONIC ACID 4-(HYDROXYMETHYL)BENZENEBORONIC ACID (4-Boronophenyl)methanol AKOS BRN-0115 4-(Hydroxymethyl)Phenylboronic 4-Boronobenzyl alcohol 4-(Hydroxymethyl)phenylboronic Acid (contains varying amounts of Anhydride) (p-HydroxyMethyl)phenylboronic acid alpha-Hydroxy-p-tolueneboronic acid B- [4-(HydroxyMethyl)phenyl]boronic acid 4-HydroMethylphenylboronicacid RARECHEM AH PB 0190 4-(Hydroxylmethyl)phenylboronic acid 4-(Hydroxymethyl)phenylboronic acid,97% 4-(Hydroxymethyl)phenylboronic acid ,98% 4-(HydroxyMethyl)phenylboronic acid, 97% 1GR 4-(HydroxyMethyl)phenylboronic acid, 97% 5GR 4-(Hydroxymethyl pPhenylboronic Acid 4-(Hydroxymethyl)benzeneboronic acid 97+% 4-(Hydroxymethyl)phenylboronicaci 59016-93-2 Boronic Acids Boronic Acids and Derivatives Organometallic Reagents Aryl blocks BoronicAcids Boronic Acid series B (Classes of Boron Compounds) Aryl Organoborons Substituted Boronic Acids Boronic acids Heterocyclic Compounds Boronic Acid Boronic Acids Boronic Acids and Derivatives bc0001