5-Amino-2-methoxypyridine
- CAS No.
- 6628-77-9
- Chemical Name:
- 5-Amino-2-methoxypyridine
- Synonyms
- 6-METHOXYPYRIDIN-3-AMINE;5-Amino-2-methoxy;3-Amino-6-methoxypy;OTAVA-BB BB7020410079;6-methoxy-3-pyridinamin;6-methoxypyridin-3-amin;6-Methoxy-3-pyridylamine;6-Methoxy-3-pyridinamine;2-Methoxypyridin-5-amine;5-amino-2-methoxy-pyridin
- CBNumber:
- CB9280737
- Molecular Formula:
- C6H8N2O
- Molecular Weight:
- 124.14
- MDL Number:
- MFCD00006264
- MOL File:
- 6628-77-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 29-31 °C (lit.) |
|---|---|
| Boiling point | 85-90 °C/1 mmHg (lit.) |
| Density | 1.575 |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform, Methanol (Slightly) |
| form | Liquid |
| pka | 4.33±0.10(Predicted) |
| color | Yellow-brown or red to very dark red |
| Water Solubility | Slightly soluble |
| InChI | 1S/C6H8N2O/c1-9-6-3-2-5(7)4-8-6/h2-4H,7H2,1H3 |
| InChIKey | UUVDJIWRSIJEBS-UHFFFAOYSA-N |
| SMILES | COc1ccc(N)cn1 |
| CAS DataBase Reference | 6628-77-9(CAS DataBase Reference) |
| FDA UNII | ATT39K5F0C |
| NIST Chemistry Reference | 5-Amino-2-methoxypyridine(6628-77-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | US1836000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Amino-2-methoxypyridine price More Price(88)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A61209 | 5-Amino-2-methoxypyridine 95% | 6628-77-9 | 25g | $139 | 2026-04-30 | Buy |
| Sigma-Aldrich | A61209 | 5-Amino-2-methoxypyridine 95% | 6628-77-9 | 5g | $55.1 | 2023-06-20 | Buy |
| TCI Chemical | A1956 | 5-Amino-2-methoxypyridine >98.0%(GC)(T) | 6628-77-9 | 5g | $39 | 2026-04-30 | Buy |
| TCI Chemical | A1956 | 5-Amino-2-methoxypyridine >98.0%(GC)(T) | 6628-77-9 | 25g | $134 | 2026-04-30 | Buy |
| Usbiological | 434884 | 5-Amino-2-methoxypyridine | 6628-77-9 | 1g | $312 | 2026-06-03 | Buy |
5-Amino-2-methoxypyridine Chemical Properties, Uses, Production
Chemical Properties
yellow-brown or red to very dark red liquid
Uses
5-Amino-2-methoxypyridine is used as a reagent in the synthesis of a novel series of thienopyrimidines as highly potent and selective PI3K inhibitors. 5-Amino-2-methoxypyridine is also used to synthesize EMPA (E521550); a novel high-affinity selective antagonist for the OX2 receptor.
Definition
ChEBI: 6-Methoxypyridin-3-amine is an aminopyridine.
Application
5-Amino-2-methoxypyridine is widely used in drug synthesis, organic synthesis and materials science due to its unique chemical properties and diverse reaction pathways.
Chemical Reactivity
The amino unit in 5-Amino-2-methoxypyridine structure has significant nucleophilicity. It can undergo condensation reactions with acyl chlorides under alkaline conditions to give the corresponding amide derivatives, and it can also undergo condensation reactions with organic carboxylic acids in the presence of condensing agents.
Synthesis
5446-92-4
6628-77-9
The general procedure for the synthesis of 5-amino-2-methoxypyridine from 5-nitro-2-methoxypyridine was as follows: 67.28 g of 2-methoxy-5-nitropyridine (0.1 mol), 0.50 g of 10% Pd/C were sequentially added to methanol, hydrogen was passed to a pressure of 0.01 MPa, and the reaction was carried out for 62±1.5 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and filtered to recover the 10% Pd/C catalyst. The filtrate was concentrated under reduced pressure to recover solvent. The residue was extracted twice with 75 g of dichloroethane and the combined extracts were washed once with purified water. Subsequently, the extract was evaporated under reduced pressure to afford a slightly yellow oily liquid 5-amino-2-methoxypyridine 11.69 g. The purity was determined by HPLC to be 97.63% and the yield was 92.03%.
References
[1] Synthesis, 2006, # 19, p. 3316 - 3340
[2] Tetrahedron Letters, 2010, vol. 51, # 5, p. 786 - 789
[3] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 1, p. 302 - 318
[4] Journal of Heterocyclic Chemistry, 1983, vol. 20, # 1, p. 199 - 203
5-Amino-2-methoxypyridine Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Huikang Boyuan Chemical Tech Co., Ltd | 010-68862197 13810598707;13810598707 | sales@huikangchem.com | China | 97 | 61 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Liaoning Tianhua Chemical Co., Ltd. | 0418-6530555 2855550 | China | 338 | 69 | |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Latest Price from 5-Amino-2-methoxypyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 6-methoxypyridin-3-amin
6628-77-9
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 5-Amino-2-methoxypyridine
6628-77-9
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-30 | 5-Amino-2-methoxypyridine
6628-77-9
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 6-methoxypyridin-3-amin
6628-77-9
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 5-Amino-2-methoxypyridine
6628-77-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Amino-2-methoxypyridine
6628-77-9
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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