2-Methylcinnamic acid
- CAS No.
- 2373-76-4
- Chemical Name:
- 2-Methylcinnamic acid
- Synonyms
- o-Methylcinnamic acid;(E)-3-(o-Tolyl)acrylic acid;5-Bromovaniline;2-Methylciamic acid;RARECHEM BK HC T303;TIMTEC-BB SBB003946;2-Methylcinnamicaci;2-METHYLCINNAMIC ACID;SPECS AI-942/25034752;METHYLCINNAMIC ACID,2-
- CBNumber:
- CB9297335
- Molecular Formula:
- C10H10O2
- Molecular Weight:
- 162.19
- MDL Number:
- MFCD00016841
- MOL File:
- 2373-76-4.mol
- MSDS File:
- SDS
| Melting point | 174-176 °C(lit.) |
|---|---|
| Boiling point | 228.88°C (rough estimate) |
| Density | 1.0281 (rough estimate) |
| refractive index | 1.5766 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | almost transparency in Methanol |
| form | powder to crystal |
| pka | 4.5(at 25℃) |
| color | White to Almost white |
| BRN | 2500607 |
| InChI | 1S/C10H10O2/c1-8-4-2-3-5-9(8)6-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-6+ |
| InChIKey | RSWBWHPZXKLUEX-VOTSOKGWSA-N |
| SMILES | Cc1ccccc1\C=C\C(O)=O |
| LogP | 2.870 (est) |
| CAS DataBase Reference | 2373-76-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
2-Methylcinnamic acid price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 433101 | 2-Methylcinnamic acid, predominantly trans 99% | 2373-76-4 | 5g | $63.1 | 2026-04-30 | Buy |
| TCI Chemical | M1295 | 2-Methylcinnamic Acid >98.0%(GC)(T) | 2373-76-4 | 5g | $36 | 2026-04-30 | Buy |
| TCI Chemical | M1295 | 2-Methylcinnamic Acid >98.0%(GC)(T) | 2373-76-4 | 25g | $117 | 2026-04-30 | Buy |
| Biosynth | FM34156 | 2-Methylcinnamic acid, predominantly trans | 2373-76-4 | 0.1kg | $150 | 2026-06-04 | Buy |
| Biosynth | FM34156 | 2-Methylcinnamic acid, predominantly trans | 2373-76-4 | 0.25kg | $292.19 | 2026-06-04 | Buy |
2-Methylcinnamic acid Chemical Properties, Uses, Production
Chemical Properties
White flakes or crystal
Uses
2-Methylcinnamic acid may be used as starting reagent for the total synthesis of the cytotoxic alkaloid, 22-hydroxyacuminatine and for the preparation of (E)-2-methylcinnamic acid i-butylammonium salt.
Definition
ChEBI: 2-Methylcinnamic Acid is a member of cinnamic acids.
General Description
2-Methylcinnamic acid has been reported to exhibit strong anti-fungal activity against white-rot fungus Lenzites betulina and brown-rot fungus Laetiporus sulphureus. Hydrogenation of 2-methylcinnamic acid using Walphos ligands and their biferrocene analogs has been studied.
Synthesis
141-82-2
529-20-4
939-57-1
GENERAL STEPS: 2-Methylbenzaldehyde (50 g, 417 mmol) was dissolved in pyridine (2 eq., 65 mL) under stirring conditions, followed by the addition of malonic acid (86.6 g, 834 mmol). The reaction mixture was heated to reflux for 4-5 hours. Upon completion of the reaction, the mixture was slowly poured into ice water and then acidified with 1N HCl. The precipitated white solid was collected by filtration, washed with water and dried under high vacuum for 3-4 h to give (E)-3-(o-tolyl)acrylic acid (57 g, 87% yield).
References
[1] Patent: US2013/178457, 2013, A1. Location in patent: Paragraph 0173
[2] Patent: WO2013/5168, 2013, A2. Location in patent: Page/Page column 32
[3] Tetrahedron Letters, 2011, vol. 52, # 41, p. 5371 - 5374
[4] Journal of Organic Chemistry, 1986, vol. 51, # 7, p. 1120 - 1123
[5] Patent: WO2013/74892, 2013, A1. Location in patent: Page/Page column 39-40
2-Methylcinnamic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 2-Methylcinnamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Methylcinnamic acid
2373-76-4
|
$1.10-34.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | 2-Methylcinnamic Acid
2373-76-4
|
$10.00 | 1KG | 99.8% | 100tons | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2020-01-13 | 2-Methylcinnamic acid
2373-76-4
|
$1.00 | 1KG | 98%-99.9% | 100kg | Career Henan Chemical Co |
-
- 2-Methylcinnamic acid
2373-76-4
- $1.10-34.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Methylcinnamic Acid
2373-76-4
- $10.00
- 99.8%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 2-Methylcinnamic acid
2373-76-4
- $1.00
- 98%-99.9%
- Career Henan Chemical Co
