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- 2-Methylcinnamic Acid
-
- $10.00
-
2026-05-28
- CAS:2373-76-4
- Min. Order: 1KG
- Purity: 99.8%
- Supply Ability: 100tons
- 2-Methylcinnamic acid
-
- $1.00
-
2020-01-13
- CAS:2373-76-4
- Min. Order: 1KG
- Purity: 98%-99.9%
- Supply Ability: 100kg
|
| | 2-Methylcinnamic acid Basic information |
| | 2-Methylcinnamic acid Chemical Properties |
| Melting point | 174-176 °C(lit.) | | Boiling point | 228.88°C (rough estimate) | | density | 1.0281 (rough estimate) | | refractive index | 1.5766 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | almost transparency in Methanol | | form | powder to crystal | | pka | 4.5(at 25℃) | | color | White to Almost white | | BRN | 2500607 | | InChI | 1S/C10H10O2/c1-8-4-2-3-5-9(8)6-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-6+ | | InChIKey | RSWBWHPZXKLUEX-VOTSOKGWSA-N | | SMILES | Cc1ccccc1\C=C\C(O)=O | | LogP | 2.870 (est) | | CAS DataBase Reference | 2373-76-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26-36-24/25 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29163990 | | Storage Class | 11 - Combustible Solids |
| | 2-Methylcinnamic acid Usage And Synthesis |
| Chemical Properties | White flakes or crystal | | Uses | 2-Methylcinnamic acid may be used as starting reagent for the total synthesis of the cytotoxic alkaloid, 22-hydroxyacuminatine and for the preparation of (E)-2-methylcinnamic acid i-butylammonium salt. | | Definition | ChEBI: 2-Methylcinnamic Acid is a member of cinnamic acids. | | General Description | 2-Methylcinnamic acid has been reported to exhibit strong anti-fungal activity against white-rot fungus Lenzites betulina and brown-rot fungus Laetiporus sulphureus. Hydrogenation of 2-methylcinnamic acid using Walphos ligands and their biferrocene analogs has been studied. | | Synthesis | GENERAL STEPS: 2-Methylbenzaldehyde (50 g, 417 mmol) was dissolved in pyridine (2 eq., 65 mL) under stirring conditions, followed by the addition of malonic acid (86.6 g, 834 mmol). The reaction mixture was heated to reflux for 4-5 hours. Upon completion of the reaction, the mixture was slowly poured into ice water and then acidified with 1N HCl. The precipitated white solid was collected by filtration, washed with water and dried under high vacuum for 3-4 h to give (E)-3-(o-tolyl)acrylic acid (57 g, 87% yield). | | References | [1] Patent: US2013/178457, 2013, A1. Location in patent: Paragraph 0173
[2] Patent: WO2013/5168, 2013, A2. Location in patent: Page/Page column 32
[3] Tetrahedron Letters, 2011, vol. 52, # 41, p. 5371 - 5374
[4] Journal of Organic Chemistry, 1986, vol. 51, # 7, p. 1120 - 1123
[5] Patent: WO2013/74892, 2013, A1. Location in patent: Page/Page column 39-40 |
| | 2-Methylcinnamic acid Preparation Products And Raw materials |
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