3-Oxoindane-1-carboxylic acid
- CAS No.
- 29427-69-8
- Chemical Name:
- 3-Oxoindane-1-carboxylic acid
- Synonyms
- 3-OXO-1-INDANCARBOXYLIC ACID;1-Indanone-3-carboxylic Acid;3-OXO-INDAN-1-CARBOXYLIC ACID;3-OXOINDANE-1-CARBOXYLIC ACID;3-Oxo-1-indan-2-carboxylic acid;3-OXO-1-INDAN-1-CARBOXYLIC ACID;3-Oxo-1-indancarboxylic acid 98%;3-oxo-1,2-dihydroindene-1-carboxylic acid;3-Oxo-2,3-dihydro-indene-1-carboxylic acid;3-Oxo-indan-1-carboxylic acid methyl ester
- CBNumber:
- CB9305409
- Molecular Formula:
- C10H8O3
- Molecular Weight:
- 176.17
- MDL Number:
- MFCD00092224
- MOL File:
- 29427-69-8.mol
- MSDS File:
- SDS
| Melting point | 111-113 °C (lit.) |
|---|---|
| Boiling point | 365.0±41.0 °C(Predicted) |
| Density | 1.384±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | solid |
| pka | 3.67±0.20(Predicted) |
| Appearance | White to off-white Solid |
| InChI | 1S/C10H8O3/c11-9-5-8(10(12)13)6-3-1-2-4-7(6)9/h1-4,8H,5H2,(H,12,13) |
| InChIKey | HXLJFMRZKCSTQD-UHFFFAOYSA-N |
| SMILES | OC(=O)C1CC(=O)c2ccccc12 |
| CAS DataBase Reference | 29427-69-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39 |
| WGK Germany | 3 |
| RTECS | NK8260000 |
| Hazard Note | Irritant |
| HS Code | 2918300090 |
| Storage Class | 11 - Combustible Solids |
3-Oxoindane-1-carboxylic acid price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 410772 | 3-Oxo-1-indancarboxylic acid 98% | 29427-69-8 | 1g | $91 | 2023-06-20 | Buy |
| Sigma-Aldrich | 410772 | 3-Oxo-1-indancarboxylic acid 98% | 29427-69-8 | 10g | $435 | 2023-06-20 | Buy |
| Apolloscientific | OR22023 | 3-oxoindane-1-carboxylic acid 95% | 29427-69-8 | 250mg | $56 | 2026-06-04 | Buy |
| Apolloscientific | OR22023 | 3-oxoindane-1-carboxylic acid 95% | 29427-69-8 | 500mg | $78 | 2026-06-04 | Buy |
| Apolloscientific | OR22023 | 3-oxoindane-1-carboxylic acid 95% | 29427-69-8 | 1g | $100 | 2026-06-04 | Buy |
3-Oxoindane-1-carboxylic acid Chemical Properties, Uses, Production
Uses
3-Oxoindane-1-carboxylic Acid is an indan acid and a potential oral hypoglycemic agents.
Definition
ChEBI: 3-oxoindane-1-carboxylic acid is a member of indanones.
Application
3-Oxoindane-1-carboxylic acid can be used as a pharmaceutical intermediate in the preparation of inhibitor molecules with antitumour activity.
Synthesis Reference(s)
Journal of the American Chemical Society, 106, p. 6702, 1984 DOI: 10.1021/ja00334a040
General Description
3-Oxo-1-indancarboxylic acid participates in the synthesis of 3-hydroxymethyl-1-indanol (±). Enantiomeric separation of 3-oxo-1-indancarboxylic acid on liquid chromatography chiral stationary phases (CSPs) by supercritical fluid chromatography (SFC) has been reported. Separation of 3-oxo-1-indancarboxylic acid enantiomers using a new immobilized polysaccharide chiral stationary phase, CHIRALPAK IA with hexane has been described.
Hazard
3-Oxoindane-1-carboxylic acid is irritating to humans. Contact causes skin irritation and severe eye irritation. Inhalation may cause respiratory irritation.
Synthesis
1131-15-3
29427-69-8
The general procedure for the synthesis of 3-carbonyl-1-indenoic acid from phenylsuccinic anhydride was as follows: phenylsuccinic anhydride (10 g, 57 mmol) was dissolved in 1,2-dichloroethane (200 mL). The solution was slowly added dropwise to a solution of 1,2-dichloroethane (50 mL) containing aluminum trichloride (17 g, 130 mmol) at 0°C. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 1 hour at room temperature. Subsequently, water (50 mL) was added at 0 °C to terminate the reaction. The reaction mixture was extracted with ethyl acetate (3 x 60 mL), the organic phases were combined and concentrated by evaporation. After drying, the light yellow oily product 5A (8.3 g, 83% yield) was obtained.
References
[1] Bulletin de la Societe Chimique de France, 1982, vol. 2, # 5-6, p. 161 - 166
[2] Patent: CN108250128, 2018, A. Location in patent: Paragraph 0195; 0197; 0198; 0199
[3] Patent: WO2016/44770, 2016, A1. Location in patent: Page/Page column 661
[4] Tetrahedron, 2004, vol. 60, # 41, p. 9245 - 9253
[5] Canadian Journal of Chemistry, 1961, vol. 39, p. 2563 - 2571
3-Oxoindane-1-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GuiZhou DoSincerely biological technology Co.,Ltd. | 13511983931 13511983931; | 271622643@qq.com | China | 8 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Shanghai Sheepchem Co., Ltd. | +86 (21) 6715-7650 | sheepchem@163.com | China | 993 | 60 |
View Latest Price from 3-Oxoindane-1-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 3-Oxoindane-1-carboxylic acid
29427-69-8
|
$1.10 | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited | |
 |
2026-03-04 | 3-Oxoindane-1-carboxylic acid
29427-69-8
|
1kg | ≥97% | 10000 | GuiZhou DoSincerely biological technology Co.,Ltd. | ||
 |
2019-12-20 | 3-Oxoindane-1-carboxylic acid
29427-69-8
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 3-Oxoindane-1-carboxylic acid
29427-69-8
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
-
- 3-Oxoindane-1-carboxylic acid
29427-69-8
- ≥97%
- GuiZhou DoSincerely biological technology Co.,Ltd.
-
- 3-Oxoindane-1-carboxylic acid
29427-69-8
- $1.00
- 99%
- Career Henan Chemical Co
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