Pyridine-2-carboxylic acid hydrazide
- CAS No.
- 1452-63-7
- Chemical Name:
- Pyridine-2-carboxylic acid hydrazide
- Synonyms
- picolinohydrazide;WS-104;NSC-81875;2-Isoniazid;AKOS B014996;2-Isoniazide;AKOS BBS-00004147;Picolinylhydrazide;Isoniazid 2-Isomer;Picoline hydrazide
- CBNumber:
- CB9306653
- Molecular Formula:
- C6H7N3O
- Molecular Weight:
- 137.14
- MDL Number:
- MFCD00059782
- MOL File:
- 1452-63-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 100°C |
|---|---|
| Boiling point | 100-102 °C |
| Density | 1.244 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 11.29±0.10(Predicted) |
| color | White to Off-White |
| InChI | 1S/C6H7N3O/c7-9-6(10)5-3-1-2-4-8-5/h1-4H,7H2,(H,9,10) |
| InChIKey | BAQLNPIEFOYKNB-UHFFFAOYSA-N |
| SMILES | NNC(=O)c1ccccn1 |
| CAS DataBase Reference | 1452-63-7(CAS DataBase Reference) |
| FDA UNII | KS1CG3S7U1 |
| UNSPSC Code | 12352125 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-24/25 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
|||||||||
| NFPA 704 |
|
Pyridine-2-carboxylic acid hydrazide price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS000511 | 2-Pyridinecarbohydrazide AldrichCPR | 1452-63-7 | 1 g | $93.2 | 2026-04-30 | Buy |
| TCI Chemical | P0426 | 2-Pyridinecarboxylic Acid Hydrazide >98.0%(T) | 1452-63-7 | 25g | $261 | 2026-04-30 | Buy |
| ChemScene | CS-W011057 | 2-Pyridinecarbohydrazide ≥98% | 1452-63-7 | 5g | $19 | 2026-06-04 | Buy |
| ChemScene | CS-W011057 | 2-Pyridinecarbohydrazide ≥98% | 1452-63-7 | 10g | $36 | 2026-06-04 | Buy |
| ChemScene | CS-W011057 | 2-Pyridinecarbohydrazide ≥98% | 1452-63-7 | 25g | $52 | 2026-06-04 | Buy |
Pyridine-2-carboxylic acid hydrazide Chemical Properties, Uses, Production
Chemical Properties
White to off-white solid
Uses
Pyridine-2-carboxylic acid hydrazide is an impurity of Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis and inhibits mycolic acid biosynthesis. Intermediate used for the synthesis of analogs of antitumor agent 1-acetyl-2-picolinoylhydrazine.
Synthesis
2524-52-9
1452-63-7
General procedure for the synthesis of 2-pyridinecarbohydrazide from ethyl 2-pyridinecarboxylate: a mixed solution of ethyl pyridine-2-carboxylate (90 g) and hydrazine hydrate (60 g) in ethanol (400 ml) was reacted with stirring at 80°C for 4 hours. After completion of the reaction, the solvent was removed by evaporation to give the crude product. The crude product was co-stirred with ether and the resulting suspension was filtered and the wet filter cake was washed with a small amount of ethanol (50 mL) to give 76 g (93% yield) of 2-pyridinecarbohydrazide as a white solid. Mass spectral data: m/z 138.0 (M+H).
References
[1] Patent: WO2010/136971, 2010, A1. Location in patent: Page/Page column 12
[2] Patent: US2012/142710, 2012, A1. Location in patent: Page/Page column 6
[3] Patent: WO2012/76989, 2012, A1. Location in patent: Page/Page column 55; 64
[4] Asian Journal of Chemistry, 2010, vol. 22, # 7, p. 5535 - 5542
[5] Patent: WO2017/106427, 2017, A1. Location in patent: Page/Page column 37-38
Pyridine-2-carboxylic acid hydrazide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
View Latest Price from Pyridine-2-carboxylic acid hydrazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
1452-63-7
|
$1.40-34.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
1452-63-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-08-08 | 2-Pyridinecarbohydrazide
1452-63-7
|
$29.00 | 99.88% | 10g | TargetMol Chemicals Inc. |
-
- PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
1452-63-7
- $1.40-34.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE
1452-63-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Pyridinecarbohydrazide
1452-63-7
- $29.00
- 99.88%
- TargetMol Chemicals Inc.
1452-63-7 (Pyridine-2-carboxylic acid hydrazide) Related Search:
1of4
