Isonicotinamide
- CAS No.
- 1453-82-3
- Chemical Name:
- Isonicotinamide
- Synonyms
- PYRIDINE-4-CARBOXAMIDE;IsoniacinaMide;NSC 82353;Isonicotimide;AURORA KA-3066;Isonicotinamid;ISONICOTINAMIDE;4-AMidopyridine;Isonicoitnamide;Isonicotinamide99%
- CBNumber:
- CB8259608
- Molecular Formula:
- C6H6N2O
- Molecular Weight:
- 122.12
- MDL Number:
- MFCD00006432
- MOL File:
- 1453-82-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 155-157 °C(lit.) |
|---|---|
| Boiling point | 227.52°C (rough estimate) |
| Density | 1.2236 (rough estimate) |
| refractive index | 1.5350 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pK1: 3.61(+1) (20°C) |
| color | White to Off-White |
| Water Solubility | 191.7 g/L (37 ºC) |
| BRN | 2173 |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChI | 1S/C6H6N2O/c7-6(9)5-1-3-8-4-2-5/h1-4H,(H2,7,9) |
| InChIKey | VFQXVTODMYMSMJ-UHFFFAOYSA-N |
| SMILES | NC(=O)c1ccncc1 |
| LogP | -0.28 |
| CAS DataBase Reference | 1453-82-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 4H3BH6YX9Q |
| NIST Chemistry Reference | 4-Pyridinecarboxamide(1453-82-3) |
| EPA Substance Registry System | Isonicotinamide (1453-82-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NR9500000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Isonicotinamide price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I17451 | Isonicotinamide ReagentPlus , 99% | 1453-82-3 | 25g | $50.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR2089 | Nicotinamide Impurity D Pharmaceutical Secondary Standard; Certified Reference Material | 1453-82-3 | 100 mg | $711 | 2026-04-30 | Buy |
| Sigma-Aldrich | I17451 | Isonicotinamide ReagentPlus , 99% | 1453-82-3 | 100g | $86.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.14032 | 4-Pyridinecarboxylic acid amide for synthesis | 1453-82-3 | 50g | $71.3 | 2022-05-15 | Buy |
| TCI Chemical | I0135 | Isonicotinamide >99.0%(HPLC)(T) | 1453-82-3 | 25g | $26 | 2026-04-30 | Buy |
Isonicotinamide Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Isonicotinamide is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly inducde apoptosis in human acute myelomonocytic leukemia cells, HL-60.
Application
Isonicotinamide (pyridine-4-carboxamide) can be used as a heterocyclic building block to synthesize:
4-oxo-1,3-thiazinan-3-yl isonicotinamide derivatives as potential anti-tubercular agents.
Organotin(IV) complexes of isonicotinamide via synthesis of phosphoramidate ligands for various biological activity studies.
Bis-pyridinium isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as potent reactivators sarin.
Isonicotinamide can also be used as a co-former with active pharmaceutical ingredients (APIs) to prepare co-crystals.
Preparation
synthesis of isonicotinamide: In 6g tert-amyl alcohol, add 100mg ferric oxide, 100mg cobalt tetroxide and 100mg manganese dioxide (mass percentage in the mixture: 4.6%), 60mg 4-cyanopyridine (mass percentage in the mixture: 0.91%), 200uL Water (mass percentage in the mixture: 3.0%), mix well; react at 80°C for 24 hours, the conversion rate of 4-cyanopyridine is 99.0%, and the selectivity of the corresponding Isonicotinamide is 99.0%.
Definition
ChEBI: Isonicotinamide is a pyridinecarboxamide that is the monocarboxylic acid amide derivative of isonicotinic acid. It derives from an isonicotinic acid.
Purification Methods
Recrystallise isonicotinamide from hot water or isopropanol (158.5-159o), and dry it in a vacuum at 100o. The picrate crystallises from aqueous EtOH or H2O and has m 217-218o (214-215o). [Beilstein 22 III/IV 527, 22/2 V 195.]
Isonicotinamide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| Jinan Wald Chemical Co., Ltd. | 0531-88773586 13210588999 | 304264064@qq.com | China | 192 | 58 |
| ShangHai Siyan Biological Technology Co., Ltd. | 021-50908862，442785678，326799392 18721037013 | siyansales@126.com | China | 9612 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Lastest Price from Isonicotinamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-21 | Isonicotinamide
1453-82-3
|
$100.00-115.00 | 100kilograms | 99% | 100tons | Hebei Dangtong Import and export Co LTD | |
 |
2026-08-20 | Isonicotinamide
1453-82-3
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-30 | Isonicotinamide
1453-82-3
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- Isonicotinamide
1453-82-3
- $100.00-115.00
- 99%
- Hebei Dangtong Import and export Co LTD
-
- Isonicotinamide
1453-82-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Isonicotinamide
1453-82-3
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
