6,8-Difluoro-4-methyl-umbelliferyl phosphate
- CAS No.
- 214491-43-7
- Chemical Name:
- 6,8-Difluoro-4-methyl-umbelliferyl phosphate
- Synonyms
- DIFMUP;DiFMU-Phos;AURORA KA-6718;6,8-Difluoro-4-methyl-umbelliferyl phosphate;2H-1-Benzopyran-2-one, 6,8-difluoro-4-methyl-7-(phosphonooxy)-;6,8-Difluoro-4-methyl-2-oxo-2H-chromen-7-yl dihydrogen phosphate
- CBNumber:
- CB9309841
- Molecular Formula:
- C10H7F2O6P
- Molecular Weight:
- 292.13
- MDL Number:
- MFCD01863005
- MOL File:
- 214491-43-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 496.0±55.0 °C(Predicted) |
|---|---|
| Density | 1.716±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | 29.21mg/ml in DMSO |
| form | A solid |
| pka | 1.48±0.10(Predicted) |
| color | White to off-white |
| Appearance | Solid Powder |
| InChI | 1S/C10H7F2O6P/c1-4-2-7(13)17-9-5(4)3-6(11)10(8(9)12)18-19(14,15)16/h2-3H,1H3,(H2,14,15,16) |
| InChIKey | DZANYXOTJVLAEE-UHFFFAOYSA-N |
| SMILES | CC1=CC(=O)Oc2c(F)c(OP(O)(O)=O)c(F)cc12 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
6,8-Difluoro-4-methyl-umbelliferyl phosphate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2821 | DiFMUP ≥98% (HPLC) | 214491-43-7 | 5 mg | $169 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2821 | DiFMUP ≥98% (HPLC) | 214491-43-7 | 25 mg | $676 | 2026-04-30 | Buy |
| Cayman Chemical | 35500 | DiFMUP ≥95% | 214491-43-7 | 1mg | $54 | 2026-04-30 | Buy |
| Cayman Chemical | 35500 | DiFMUP ≥95% | 214491-43-7 | 5mg | $149 | 2026-04-30 | Buy |
| ChemScene | CS-0077049 | DiFMUP ≥98% | 214491-43-7 | 5mg | $152 | 2026-06-04 | Buy |
6,8-Difluoro-4-methyl-umbelliferyl phosphate Chemical Properties, Uses, Production
Description
6,8-difluoro-4-methylumbelliferyl phosphate is a fluorogenic substrate for protein tyrosine phosphatase.
Uses
DiFMUP is a fluorogenic substrate, and has been widely used for the continuous detection of phosphatase activities. DiFMUP is hydrolysis by a phosphatase results in the release of Xuorescent DIFMU, which can be easily followed in continuous mode by a Xuorescence reader[1][2].
Definition
ChEBI: 6,8-difluoro-4-methylumbelliferyl phosphate is a member of coumarins. It is functionally related to a coumarin. It is a conjugate acid of a 6,8-difluoro-4-methylumbelliferyl phosphate (2-).
Biological Activity
DiFMUP (6,8-difluoro-4-methylumbelliferyl phosphate), a fluorinated analog of MUP, is a fluorescent synthetic substrate for continuous assessment of phosphatase activity. DiFMUP excitation/emission maxima are 358/450 nm.
storage
Store at -20°C
References
[1] Gee KR, et, al. Fluorogenic substrates based on fluorinated umbelliferones for continuous assays of phosphatases and beta-galactosidases. Anal Biochem. 1999 Aug 15;273(1):41-8. DOI:10.1006/abio.1999.4202
[2] Welte S, et, al. 6,8-Difluoro-4-methylumbiliferyl phosphate: a fluorogenic substrate for protein tyrosine phosphatases. Anal Biochem. 2005 Mar 1;338(1):32-8. DOI:10.1016/j.ab.2004.11.047
6,8-Difluoro-4-methyl-umbelliferyl phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
6,8-Difluoro-4-methyl-umbelliferyl phosphate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301590 | njduly@126.com | China | 3293 | 55 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9170 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9792 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Shenzhen GeneSeqTools Bioscience & Technology Co. Ltd. | 0755-23251735 13302967066 | sales@geneseqtools.com | China | 1466 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
