Forodesine
- CAS No.
- 1191450-19-7
- Chemical Name:
- Forodesine
- Synonyms
- Burixafor HBr;TG-0054 hydrobromide;Burixafor hydrobromide (TG-0054 hydrobromide);Burixafor hydrobromide (Synonyms: TG-0054 hydrobromide)
- CBNumber:
- CB93159904
- Molecular Formula:
- C27H52BrN8O3P
- Molecular Weight:
- 647.64
- MDL Number:
- MFCD31813774
- MOL File:
- 1191450-19-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Forodesine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | RXB45019 | Burixafor hydrobromide | 1191450-19-7 | 100mg | $995 | 2026-06-05 | Buy |
| ChemScene | CS-0085196 | Burixafor hydrobromide 98.0% | 1191450-19-7 | 5mg | $108 | 2026-06-04 | Buy |
| ChemScene | CS-0085196 | Burixafor hydrobromide 98.0% | 1191450-19-7 | 10mg | $162 | 2026-06-04 | Buy |
| ChemScene | CS-0085196 | Burixafor hydrobromide 98.0% | 1191450-19-7 | 25mg | $325 | 2026-06-04 | Buy |
| ChemScene | CS-0085196 | Burixafor hydrobromide 98.0% | 1191450-19-7 | 50mg | $487 | 2026-06-04 | Buy |
Forodesine Chemical Properties, Uses, Production
Description
Burixafor, also known as TG-0054, is an orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities. Burixafor binds to the chemokine receptor CXCR4, thereby preventing the binding of stromal derived factor-1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation; this may the mobilization of hematopoietic stem and progenitor cells from the bone marrow into blood. Note: Elemental analysis showed it was a salt with 3 HBr and 3 water.
Uses
Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent antagonist of CXCR4 and a well anti-angiogenic drug that is of potential value in treating choroid neovascularization[1]. Burixafor hydrobromide (TG-0054 hydrobromide) mobilizes mesenchymal stem cells, attenuates inflammation, and preserves cardiac systolic function in a porcine model of myocardial infarction[2].
IC 50
CXCR4
References
[1] Shelke NB, et al. Intravitreal Poly(L-lactide) Microparticles Sustain Retinal and Choroidal Delivery of TG-0054, a Hydrophilic Drug Intended for Neovascular Diseases. Drug Deliv Transl Res. 2011 Feb;1(1):76-90. DOI:10.1007/s13346-010-0009-8
[2] Hsu WT, et al. CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction. Cell Transplant. 2015;24(7):1313-28. DOI:10.3727/096368914X681739
Forodesine Preparation Products And Raw materials
Raw materials
Preparation Products
Forodesine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 18108052721 | 2850505130@qq.com | China | 5037 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
| Supplier | Advantage |
|---|---|
| Fan De(Beijing) Biotechnology Co., Ltd. | 58 |
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| InvivoChem | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
| InvivoChem | 58 |
| Aladdin Scientific | 58 |
