3-Fluoro-4-broMoaniline
- CAS No.
- 656-65-5
- Chemical Name:
- 3-Fluoro-4-broMoaniline
- Synonyms
- 4-BROMO-3-FLUOROANILINE;4-Bromo-3-fluoroanil;3-Fluoro-4-broMoanilin;4-Bromo-3-fluoroaniline98%;4-Bromo-3-fluorobenzenamine;4-BROMO-3-FLUOROPHENYLAMINE;4-Bromo-3-fluoroaniline >4-BroMo-3-fluoroaniline, 97+%;Benzenamine, 4-bromo-3-fluoro-;4 - broMine - 3 - fluoro aniline
- CBNumber:
- CB9345779
- Molecular Formula:
- C6H5BrFN
- Molecular Weight:
- 190.01
- MDL Number:
- MFCD00672933
- MOL File:
- 656-65-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 72-73°C |
|---|---|
| Boiling point | 65-68 °C (lit.) |
| Density | 0.982 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 105 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Acetonitrile, Methanol |
| form | Crystalline Powder |
| pka | 2.88±0.10(Predicted) |
| color | Yellow to tan |
| Water Solubility | Soluble in acetonitrile, methanol. Insoluble in water. |
| BRN | 3236457 |
| InChI | InChI=1S/C6H5BrFN/c7-5-2-1-4(9)3-6(5)8/h1-3H,9H2 |
| InChIKey | YTMVYYAKOPIJCZ-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(Br)C(F)=C1 |
| CAS DataBase Reference | 656-65-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,T,Xn | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Toxic | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214200 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Fluoro-4-broMoaniline price More Price(98)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 518719 | 4-Bromo-3-fluoroaniline 97% | 656-65-5 | 5g | $33.3 | 2026-04-30 | Buy |
| TCI Chemical | B2102 | 4-Bromo-3-fluoroaniline >98.0%(GC) | 656-65-5 | 1g | $24 | 2026-04-30 | Buy |
| TCI Chemical | B2102 | 4-Bromo-3-fluoroaniline >98.0%(GC) | 656-65-5 | 5g | $65 | 2026-04-30 | Buy |
| Usbiological | 263634 | 4-Bromo-3-fluoroaniline Asreported | 656-65-5 | 50g | $502 | 2026-06-03 | Buy |
| Usbiological | 263634 | 4-Bromo-3-fluoroaniline Asreported | 656-65-5 | 100g | $741 | 2026-06-03 | Buy |
3-Fluoro-4-broMoaniline Chemical Properties,Uses,Production
Chemical Properties
Beige to brown needles and crystalline powder
Uses
4-Bromo-3-fluoroaniline is a intermediate used for the synthetic preparation of Tradizolid and various pharmaceuticals such as the synthesis of several lateral difluoro-substituted 4,4"-dialkyl- and 4 ,4"-alkoxyalkylterphenyls.
Uses
4-Bromo-3-fluoroaniline is an intermediate used for the synthetic preparation of Tradizolid and various pharmaceuticals such as the synthesis of several lateral difluoro-substituted 4,4"-dialkyl- and 4,4"-alkoxyalkylterphenyls.
Synthesis
351-30-4
656-65-5
General procedure for the synthesis of 4-bromo-3-fluoroaniline from 3-fluoro-4-bromoacetanilide: N-(4-bromo-3-fluorophenyl)acetamide (12.9 g, 12.9 mmol) was dissolved in ethanol (30 mL), and stirred until completely dissolved. Subsequently, concentrated hydrochloric acid (15 mL) was added to the solution and the reaction was refluxed at 80 °C for 4 hours. Upon completion of the reaction, the reaction mixture was diluted with ice water and extracted with ethyl acetate. The organic layers were combined and washed sequentially with water and brine solution. Finally, the solvent was removed by vacuum distillation to afford 4-bromo-3-fluoroaniline (2.45 g, 100.0% yield) as an off-white solid.
References
[1] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 97; 98
[2] Molecular Crystals and Liquid Crystals (1969-1991), 1991, vol. 204, p. 43 - 64
[3] Journal of the Chemical Society, 1958, p. 2815,2818
3-Fluoro-4-broMoaniline Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Dongyang Qiusuo Medical Technology Co., LTD | 17502510579 | 2785299132@qq.com | China | 1557 | 58 |
| Jinan XuanDe Chemical Co., Ltd. | 0531-88803958 19862127196 | zhangxu@shiningpharm.com | China | 201 | 58 |
| Yancheng ZhengChi biological and Technology Co, Ltd. | 0515-88230089 18014968800 | wzfan1984@163.com | China | 18 | 55 |
| Hangzhou Copiore Chemical Co., Ltd. | 17300981287 13757145729 | sales@copiore.com | China | 289 | 58 |
| ZHUHAI HRD PHARMACEUTICAL CO., LTD. | 7737188 13326687259 | sales@hrdpharm.com | China | 141 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
View Lastest Price from 3-Fluoro-4-broMoaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4-Bromo-3-fluoroaniline
656-65-5
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-13 | 3-Fluoro-4-broMoaniline
656-65-5
|
1G | 99% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2026-06-30 | 3-Fluoro-4-broMoaniline
656-65-5
|
1kg | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd |
-
- 4-Bromo-3-fluoroaniline
656-65-5
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 3-Fluoro-4-broMoaniline
656-65-5
- 99%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 3-Fluoro-4-broMoaniline
656-65-5
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
656-65-5(3-Fluoro-4-broMoaniline)Related Search:
1of4
