Clasto-Lactacystin ?-lactone
- CAS No.
- 154226-60-5
- Chemical Name:
- Clasto-Lactacystin ?-lactone
- Synonyms
- clasto-lactacystin β-lactone;OMURALIDE;BETA-CLASTOLACTACYSTIN;Clasto-lactacystin (OMuralide);CLASTO-LACTACYSTIN BETA-LACTONE;LACTACYSTIN, CLASTO-, BETA-LACTONE;clasto-Lactacystin β-Lactone;clasto-Lactacystin beta-lactone, 20S proteasome inhibitor;1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE;(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
- CBNumber:
- CB9352564
- Molecular Formula:
- C10H15NO4
- Molecular Weight:
- 213.23
- MDL Number:
- MFCD01076526
- MOL File:
- 154226-60-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 186-187°C |
|---|---|
| Boiling point | 440.815±40.00 °C(Press: 760.00 Torr)(predicted) |
| Density | 1.280±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | -20°C |
| solubility | DMF, Ethanol, Hot Ethyl Acetate, Methanol, Pyridine |
| form | White solid |
| pka | 13.332±0.20(predicted) |
| color | White |
| InChI | 1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1 |
| InChIKey | FWPWHHUJACGNMZ-NBBQQVJHSA-N |
| SMILES | [H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 20/21/22-37/38-41-36/37/38-25 | |||||||||
| Safety Statements | 16-26-36/37/39-45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 2 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| NFPA 704 |
|
Clasto-Lactacystin ?-lactone price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L7035 | clasto-Lactacystin β-lactone | 154226-60-5 | 0.1mg | $478 | 2026-04-30 | Buy |
| Sigma-Aldrich | 426102 | clasto-Lactacystinβ-Lactone-CAS154226-60-5-Calbiochem Ahighlyspecific,cell-permeable,andirreversible20Sproteasomeinhibitor. | 154226-60-5 | 100μg | $433 | 2026-04-30 | Buy |
| Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 154226-60-5 | 50μg | $77 | 2026-04-30 | Buy |
| Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 154226-60-5 | 100μg | $139 | 2026-04-30 | Buy |
| Cayman Chemical | 70988 | Clasto-Lactacystin β-lactone ≥95% | 154226-60-5 | 500μg | $578 | 2026-04-30 | Buy |
Clasto-Lactacystin ?-lactone Chemical Properties, Uses, Production
Chemical Properties
White Solid
Uses
A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
Uses
Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.
Uses
clasto-Lactacystin beta-lactone is a 20S proteasome and cathepsin A inhibitor.
Biological Activity
cell-permeable. a highly specific, potent and irreversible proteasome inhibitor. lactacystin (cat. no. 1709-200) acts as a precursor for clasto-lactacystin β-lactone and the latter compound is at least 10 times more active than the parent lactacystin
Biochem/physiol Actions
Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcaniiby acting in the N-threonine residue of the β -type subunits.
Clasto-Lactacystin ?-lactone Preparation Products And Raw materials
Raw materials
Preparation Products
Clasto-Lactacystin ?-lactone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| ApexBio Technology LLC | +1-832-696-8203 | info@apexbt.com | United States | 477 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44927 | 58 |
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