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5-Hydroxymethylpyrrolidin-2-one

5-Hydroxymethylpyrrolidin-2-one structure

CAS No.: 66673-40-3

Chemical Name:: 5-Hydroxymethylpyrrolidin-2-one

Synonyms: D-PYROGLUTAMINOL;D-Pyr-ol;H-D-Pyr-ol;(-)-D-PYROGLUTAMOL;(R)-(-)-5-(HydroxymethyL;5-Hydroxymethylpyrrolidin-2-one;5-(Hydroxymethyl)-2-pyrrolidinone;(R)-(-)-2-PYRROLIDONE-5-YL-METHANOL;(R)-5-HYDROXYMETHYL-PYRROLIDIN-2-ONE;(R)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE

CBNumber:: CB2304847

Molecular Formula:: C5H9NO2

Molecular Weight:: 115.13

MDL Number:: MFCD00077791

MOL File:: 66673-40-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:10:09

Product description	Number	Pack Size	Price
(R)-(?)-5-(Hydroxymethyl)-2-pyrrolidinone 99%	366358	1g	$45.1
(R)-(?)-5-(Hydroxymethyl)-2-pyrrolidinone 99%	366358	5g	$177
(R)-5-(Hydroxymethyl)-2-pyrrolidinone >98.0%(GC)(N)	H1241	1g	$57
(R)-5-(Hydroxymethyl)-2-pyrrolidinone >98.0%(GC)(N)	H1241	5g	$158
(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone	H9110-15M	1g	$319
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5-Hydroxymethylpyrrolidin-2-one Properties

Melting point	83-85 °C(lit.)
Boiling point	147-149 °C0.06 mm Hg(lit.)
Density	1.1808 (rough estimate)
refractive index	-31 ° (C=5, EtOH)
Flash point	147-149°C/0.06m
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform, Dimethylformamide, Water
pka	14.35±0.10(Predicted)
form	Crystalline Powder or Flakes
color	White to yellow
optical activity	[α]20/D 31°, c = 5 in ethanol
BRN	5728422
InChI	1S/C5H9NO2/c7-3-4-1-2-5(8)6-4/h4,7H,1-3H2,(H,6,8)/t4-/m1/s1
InChIKey	HOBJEFOCIRXQKH-SCSAIBSYSA-N
SMILES	OC[C@H]1CCC(=O)N1
CAS DataBase Reference	66673-40-3(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

3-10

HS Code

29337900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

5-Hydroxymethylpyrrolidin-2-one price More Price(75)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	366358	(R)-(?)-5-(Hydroxymethyl)-2-pyrrolidinone 99%	66673-40-3	1g	$45.1	2023-06-20	Buy
Sigma-Aldrich	366358	(R)-(?)-5-(Hydroxymethyl)-2-pyrrolidinone 99%	66673-40-3	5g	$177	2023-06-20	Buy
TCI Chemical	H1241	(R)-5-(Hydroxymethyl)-2-pyrrolidinone >98.0%(GC)(N)	66673-40-3	1g	$57	2026-04-30	Buy
TCI Chemical	H1241	(R)-5-(Hydroxymethyl)-2-pyrrolidinone >98.0%(GC)(N)	66673-40-3	5g	$158	2026-04-30	Buy
Usbiological	H9110-15M	(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone	66673-40-3	1g	$319	2026-06-03	Buy

Product number	Packaging	Price	Buy
366358	1g	$45.1	Buy
366358	5g	$177	Buy
H1241	1g	$57	Buy
H1241	5g	$158	Buy
H9110-15M	1g	$319	Buy

5-Hydroxymethylpyrrolidin-2-one Chemical Properties,Uses,Production

Chemical Properties

(R)-5-(Hydroxymethyl)-2-pyrrolidinone is White Powder

Uses

(R)-5-(Hydroxymethyl)-2-pyrrolidinone is a 2-pyrrolidone derivative for therapeutic use as prostanoid receptor agonist.

Uses

Serves as a building block in the synthesis of diphthamide.

Synthesis

64700-65-8

66673-40-3

Scheme 1, Step B: Preparation of (R)-(-)-5-(hydroxymethyl)-2-pyrrolidinone (3) To a solution of methanol (100 mL) containing methyl (R)-5-oxopyrrolidine-2-carboxylate (Intermediate 2, 13.2 g), sodium borohydride (10.5 g, 278 mmol) was added in batches at 0 °C. The reaction mixture was stirred continuously at 0 °C until the reaction was complete, followed by the addition of acetic acid (3 mL) to quench the reaction. The reaction mixture was concentrated and the residue was purified by silica gel column chromatography using methanol-chloroform (1:9, v/v) as eluent to afford the target product (12.9 g, 97% yield) as a colorless solid. Thin-layer chromatography (TLC) showed an Rf value of 0.33 (unfolding agent system: methanol-chloroform, 1:9, v/v); nuclear magnetic resonance hydrogen spectrum (1H-NMR, CDCl3) δ: 7.17 (s, 1H), 3.92 (s, 1H), 3.85-3.75 (m, 1H), 3.64-3.40 (m, 2H), 2.42-2.35 (m. 2H), 2.2-2.05 (m, 1H), 1.88-1.7 (m, 1H).

References

[1] Patent: WO2014/15246, 2014, A1. Location in patent: Paragraph 0447-0448
[2] Patent: WO2014/144610, 2014, A1. Location in patent: Paragraph 0368; 0377; 0378
[3] Patent: WO2015/9991, 2015, A2. Location in patent: Paragraph 0555-0556
[4] Patent: US2016/60216, 2016, A1. Location in patent: Paragraph 0371-0372
[5] Patent: KR2015/130326, 2015, A. Location in patent: Page/Page column 0409-0411

5-Hydroxymethylpyrrolidin-2-one Preparation Products And Raw materials

Raw materials

Ethanol L-Glutamic acid Sodium borohydride D(-)-Glutamic acid Tetrahydrofuran

Ethyl acetate Hydrochloric acid Acetic acid Lithium chloride (-)-D-PYROGLUTAMIC ACID METHYL ESTER

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Preparation Products

D-Pyroglutamic acid (+)-D-PYROGLUTAMOL P-TOLUENESULFONATE

5-Hydroxymethylpyrrolidin-2-one Suppliers

Global( 253)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-15680023009	ni@enlaibio.com	China	1103	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20111	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3004	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21189	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10817	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58

Supplier	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 5-Hydroxymethylpyrrolidin-2-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-14	(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone 66673-40-3	$1.00-200.00	1KG	99%, 99.5% Sublimated		Henan Fengda Chemical Co., Ltd
2026-08-14	D-Pyr-ol 66673-40-3		1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2021-07-02	5-Hydroxymethylpyrrolidin-2-one 66673-40-3	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone
66673-40-3
$1.00-200.00
99%, 99.5% Sublimated
Henan Fengda Chemical Co., Ltd

D-Pyr-ol
66673-40-3
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

5-Hydroxymethylpyrrolidin-2-one
66673-40-3
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

5-Hydroxymethylpyrrolidin-2-one Spectrum

5-Hydroxymethylpyrrolidin-2-one(66673-40-3)¹HNMR 5-Hydroxymethylpyrrolidin-2-one(66673-40-3)Raman 5-Hydroxymethylpyrrolidin-2-one(66673-40-3)IR 5-Hydroxymethylpyrrolidin-2-one(66673-40-3)FT-IR

66673-40-3(5-Hydroxymethylpyrrolidin-2-one)Related Search:

5-Hydroxymethylpyrrolidin-2-one 2-Pyrrolidone-5-carboxylic acid sodium salt Ethyl L-pyroglutamate DIRHODIUM (II) TETRAKIS(METHYL 2-PYRROLIDONE-5(R)-CARBOXYLATE)ACETONITRILE/2-PROPANOL COMPLEX Cyclopentene oxide

L-PYROGLUTAMIC ACID PENTACHLOROPHENYL ESTER CLASTO-LACTACYSTIN EQUISETIN Ethyl D-(-)-pyroglutamate DL-Pyroglutamic acid

D-Pyroglutamic acid L-Arginine-L-pyroglutamate Z-PYR-OH Z-D-PYR-OH CALCIUM PIDOLATE

(S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate L-Pyroglutaminol ALPHA-PYRIDOIN

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(-)-D-PYROGLUTAMOL (R)-5-HYDROXYMETHYL-PYRROLIDIN-2-ONE (R)-(-)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE (R)-5-(HYDROXYMETHYL)-2-PYRROLIDINONE (R)-(-)-5-(HYDROXYMETHYL)-2-PYRROLIDONE (R)-(-)-2-PYRROLIDONE-5-YL-METHANOL 5-(Hydroxymethyl)-2-pyrrolidinone 5-Hydroxymethylpyrrolidin-2-one H-D-Pyr-ol (R)-(-)-5-Hydroxymethyl-2-pyrrolidinone,98% (5R)-5-(Hydroxymethyl)-2-pyrrolidinone (5R)-5-(Hydroxymethyl)pyrrolidin-2-one (2)(R)-5-(HydroxyMethyl)-2-pyrrolidinone (R)-5-(Hydroxymethyl)-2-pyrrolidinone (R)-5-(Hydroxymethyl)-2-pyrrolidinone,99%e.e. (R)-5-(Hydroxymethyl)-2-pyrrolidinone> (R)-(-)-5-(HydroxymethyL 2-Pyrrolidinone, 5-(hydroxymethyl)-, (5R)- 5-Hydroxymethylpyrrolidin-2-one USP/EP/BP D-Pyr-ol D-PYROGLUTAMINOL 66673-40-3 6673-40-3 Heterocyclic Building Blocks Pyrrolidines ALCOHOL Chiral Building Blocks Asymmetric Synthesis Heterocycles pharmacetical Amino Acids 13C, 2H, 15N Amides (Chiral) Chiral Building Blocks Synthetic Organic Chemistry Amino Acids & Derivatives Chiral Reagents