(Pyrazin-2-ylmethyl)amine
- CAS No.
- 20010-99-5
- Chemical Name:
- (Pyrazin-2-ylmethyl)amine
- Synonyms
- 2-Pyrazinemethanamine;RARECHEM AL BW 0125;2-AMINOMETHYL PYRAZINE;2-(Aminomethyl)pyradine;2-Pyrazin-2-ylmethanamine;Pyrazinemethanamine (9CI);(Pyrazin-2-ylmethyl)amine;1-(2-Pyrazinyl)methanamine;2-Aminomethylpyrazine ,97%;2-(Aminomethyl)pyrazine 97%
- CBNumber:
- CB9410178
- Molecular Formula:
- C5H7N3
- Molecular Weight:
- 109.13
- MDL Number:
- MFCD00673149
- MOL File:
- 20010-99-5.mol
- MSDS File:
- SDS
| Melting point | 125 °C |
|---|---|
| Boiling point | 117-118 °C |
| Density | 1.138g/ml |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | liquid |
| pka | 8.13±0.40(Predicted) |
| color | Clear, dark yellow |
| Stability | Hygroscopic |
| InChI | InChI=1S/C5H7N3/c6-3-5-4-7-1-2-8-5/h1-2,4H,3,6H2 |
| InChIKey | HQIBSDCOMQYSPF-UHFFFAOYSA-N |
| SMILES | C1(CN)=NC=CN=C1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H312-H332-H315-H318-H335 |
| Precautionary statements | P260-P271-P280 |
| Hazard Codes | Xi,T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN2811 |
| WGK Germany | WGK 3 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
(Pyrazin-2-ylmethyl)amine price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | P3116 | Pyrazin-2-ylmethanamine min. 95.0 % | 20010-99-5 | 1G | $35 | 2026-04-30 | Buy |
| TRC | TRC-A617440-5G | 2-(Aminomethyl)pyrazine | 20010-99-5 | 5g | $205 | 2026-06-03 | Buy |
| TRC | TRC-A617440-1G | 2-(Aminomethyl)pyrazine | 20010-99-5 | 1g | $154 | 2026-06-03 | Buy |
| TRC | TRC-A617440-10G | 2-(Aminomethyl)pyrazine | 20010-99-5 | 10g | $307 | 2026-06-03 | Buy |
| Biosynth | FA73280 | 2-Aminomethylpyrazine | 20010-99-5 | 10g | $250 | 2026-06-04 | Buy |
(Pyrazin-2-ylmethyl)amine Chemical Properties, Uses, Production
Uses
2-(Aminomethyl)pyrazine is a useful synthetic intermediate. It is used to synthesize pyrazolo[4,3-c]pyridinediones as orally bioavailable NADPH oxidase isoform 4 inhibitors for the treatment of idiopathic pulmonary fibrosis. It is also used to prepare pyrazolyl-indoles with the abilities to induce T-cell kinase inhibition.
Synthesis
19847-12-2
20010-99-5
The general procedure for the synthesis of 2-aminomethylpyrazine from 2-cyanopyrazine is as follows: the method described in the literature (JP A 2001-894594) was referred to as follows. The raw material 2-cyanopyridine was purchased from Sigma-Aldrich Co. LLC. 1.05 g (10 mmol) of 2-cyanopyridine and 100 mg of 60 wt% Ni/SiO2 catalyst were placed in 20 mL of toluene and loaded into an autoclave (model 5U5316), followed by argon replacement of the air in the autoclave. The reaction was pressurized to 50 atm under hydrogen atmosphere and stirred at 140 °C reaction temperature for 4 hours. Upon completion of the reaction, the reaction solution was filtered to remove the catalyst and the filtrate was concentrated to quantitatively obtain the target product 2-aminomethylpyridine (2-AMPZ). The product was characterized by 1H-NMR (399.78 MHz, CDCl3): δ 8.60-8.45 (m, 3H), 4.07 (s, 2H), 1.79 (br, 2H).
References
[1] Patent: US2015/31920, 2015, A1. Location in patent: Paragraph 0150; 0151; 0152
[2] Patent: EP2230241, 2010, A1. Location in patent: Page/Page column 18
[3] Patent: EP2404921, 2012, A1. Location in patent: Page/Page column 9
[4] Patent: US2012/65209, 2012, A1. Location in patent: Page/Page column 9
[5] Patent: TWI522358, 2016, B. Location in patent: Page/Page column 15; 18
(Pyrazin-2-ylmethyl)amine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Targsense Scientific Co., Ltd. | 18916626092 | targsense@qq.com | China | 110 | 65 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from (Pyrazin-2-ylmethyl)amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | (PYRAZIN-2-YLMETHYL)AMINE
20010-99-5
|
$1.10 | 1g | 99.0% Min | 100 Tons | Dideu Industries Group Limited | |
 |
2026-05-28 | (PYRAZIN-2-YLMETHYL)AMINE
20010-99-5
|
$10.00 | 1KG | 99.% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2024-04-28 | (PYRAZIN-2-YLMETHYL)AMINE
20010-99-5
|
$10.00 | 1kg | 99.6% | 100000 | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- (PYRAZIN-2-YLMETHYL)AMINE
20010-99-5
- $1.10
- 99.0% Min
- Dideu Industries Group Limited
-
- (PYRAZIN-2-YLMETHYL)AMINE
20010-99-5
- $10.00
- 99.%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- (PYRAZIN-2-YLMETHYL)AMINE
20010-99-5
- $10.00
- 99.6%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
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