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METHYL PYRAZINE-2-CARBOXYLATE

METHYL PYRAZINE-2-CARBOXYLATE structure

CAS No.: 6164-79-0

Chemical Name:: METHYL PYRAZINE-2-CARBOXYLATE

Synonyms: PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER;METHYL PYRAZINOATE;METHYL PYRAZINE-2-CA;Aaptamine Impurity 9;METHYL PYRAZINECARBOXYLATE;Pyrazinoic acid methyl ester;METHYL 2-PYRAZINECARBOXYLATE;METHYL PYRAZINE-2-CARBOXYLATE;Pyrazinecarboxylic acid methyl;Methyl2-Pyrazinecarboxylate>

CBNumber:: CB5369861

Molecular Formula:: C6H6N2O2

Molecular Weight:: 138.12

MDL Number:: MFCD00014611

MOL File:: 6164-79-0.mol

MSDS File:: SDS

Last updated:2026-05-28 01:56:26

Product description	Number	Pack Size	Price
Methyl 2-pyrazinecarboxylate 97%	519677	5g	$244
Methyl 2-Pyrazinecarboxylate >98.0%(GC)	M2015	5g	$87
Methyl 2-Pyrazinecarboxylate >98.0%(GC)	M2015	25g	$255
Methyl pyrazine-2-carboxylate >97%	OR6399	25g	$24
Methyl pyrazine-2-carboxylate >97%	OR6399	100g	$79
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METHYL PYRAZINE-2-CARBOXYLATE Properties

Melting point	57-61 °C(lit.)
Boiling point	104°C/7mmHg(lit.)
Density	1.213±0.06 g/cm3(Predicted)
Flash point	>100°(212°F)
storage temp.	Sealed in dry,Room Temperature
form	Liquid
pka	-0.91±0.10(Predicted)
color	Clear colorless
Merck	14,7959
BRN	118345
InChI	InChI=1S/C6H6N2O2/c1-10-6(9)5-4-7-2-3-8-5/h2-4H,1H3
InChIKey	TWIIRMSFZNYMQE-UHFFFAOYSA-N
SMILES	C1(C(OC)=O)=NC=CN=C1
LogP	-0.230
CAS DataBase Reference	6164-79-0(CAS DataBase Reference)
FDA UNII	90NZ6P9NG2
EPA Substance Registry System	Pyrazinecarboxylic acid, methyl ester (6164-79-0)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

METHYL PYRAZINE-2-CARBOXYLATE price More Price(65)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	519677	Methyl 2-pyrazinecarboxylate 97%	6164-79-0	5g	$244	2023-06-20	Buy
TCI Chemical	M2015	Methyl 2-Pyrazinecarboxylate >98.0%(GC)	6164-79-0	5g	$87	2026-04-30	Buy
TCI Chemical	M2015	Methyl 2-Pyrazinecarboxylate >98.0%(GC)	6164-79-0	25g	$255	2026-04-30	Buy
Apolloscientific	OR6399	Methyl pyrazine-2-carboxylate >97%	6164-79-0	25g	$24	2026-06-04	Buy
Apolloscientific	OR6399	Methyl pyrazine-2-carboxylate >97%	6164-79-0	100g	$79	2026-06-04	Buy

Product number	Packaging	Price	Buy
519677	5g	$244	Buy
M2015	5g	$87	Buy
M2015	25g	$255	Buy
OR6399	25g	$24	Buy
OR6399	100g	$79	Buy

METHYL PYRAZINE-2-CARBOXYLATE Chemical Properties,Uses,Production

Chemical Properties

White solid

Synthesis

67-56-1

98-97-5

6164-79-0

To a solution of 2-pyrazinecarboxylic acid (5.80 g, 46.5 mmol) in dichloromethane (100 mL) was slowly added oxalyl chloride (5.10 mL, 60.4 mmol), followed by the addition of a catalytic amount of DMF.The reaction mixture was stirred for 6 hr. at 23° C. The reaction was completed with the addition of methanol (30 mL). After completion of the reaction, methanol (30 mL) was added slowly and stirring was continued for 30 min. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (200 mL) and washed sequentially with saturated aqueous sodium bicarbonate (1 x 100 mL) and brine (1 x 100 mL). The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford 3.38 g (53% yield) of the crude methyl pyrazine-2-carboxylate, which could be used in the next step of the reaction without further purification.1H NMR (400 MHz, CDCl3): δ 9.34 (d, 1H), 8.79 (d, 1H), 8.74 (dd, 1H), 4.06 (s 3H); LCMS (Method A): tR = 0.48 min, m/z 139.3 (M + H)+.

References

[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2843 - 2851
[2] Journal of the American Chemical Society, 1990, vol. 112, # 17, p. 6248 - 6254
[3] Patent: WO2004/48369, 2004, A1. Location in patent: Page 8
[4] Tetrahedron Letters, 2009, vol. 50, # 28, p. 4030 - 4032
[5] Patent: WO2016/207914, 2016, A2. Location in patent: Page/Page column 3; 13; 14

METHYL PYRAZINE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Methanol 2-Pyrazinecarboxylic acid Iodomethane N,N-Dimethylformamide Dichloromethane

Oxalyl chloride

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Preparation Products

METHYL 2-CHLORO-6-PYRAZINECARBOXYLATE (PYRAZIN-2-YLMETHYL)AMINE Pyrazinecarbonyl chloride, 6-chloro- (9CI) 6-Chloro-N-(3-isopropoxyphenyl)pyrazine-2-carboxamide

METHYL PYRAZINE-2-CARBOXYLATE Suppliers

Global( 250)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	9976	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shanghai Arbor Chemical Co., Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from METHYL PYRAZINE-2-CARBOXYLATE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	METHYL PYRAZINE-2-CARBOXYLATE 6164-79-0	$1.10	1g	99.00%	100 Tons	Dideu Industries Group Limited
2020-04-29	Methyl pyrazine-2-carboxylate 6164-79-0		1KG	99.0%+	800 tons	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	METHYL PYRAZINE-2-CARBOXYLATE 6164-79-0	$8.00	1kg	99%	10tons	Career Henan Chemical Co

METHYL PYRAZINE-2-CARBOXYLATE
6164-79-0
$1.10
99.00%
Dideu Industries Group Limited

Methyl pyrazine-2-carboxylate
6164-79-0
99.0%+
Shaanxi Dideu Medichem Co. Ltd

METHYL PYRAZINE-2-CARBOXYLATE
6164-79-0
$8.00
99%
Career Henan Chemical Co

METHYL PYRAZINE-2-CARBOXYLATE Spectrum

METHYL PYRAZINE-2-CARBOXYLATE(6164-79-0)¹HNMR

6164-79-0(METHYL PYRAZINE-2-CARBOXYLATE)Related Search:

METHYL 3-AMINO-5,6-DICHLORO-2-PYRAZINECARBOXYLATE METHYL PYRAZINE-2-CARBOXYLATE Methyl 3-amino-2-pyrazinecarboxylate 2,3-Pyrazinecarboxylic anhydride ETHYL 2-QUINOXALINECARBOXYLATE

Furo[2,3-b]pyrazine-6-carboxylic acid, 7-amino-, ethyl ester (9CI) Methyl 5-chloropyrazine-2-carboxylate METHYL 5-BROMOPYRAZINE-2-CARBOXYLATE 3-AMINO-6-IODOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER 5-Hydroxypyrazine-2-carboxylic acid methyl ester

Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI) Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate Methyl 3-Amino-6-Bromopyrazine-2-Carboxylic Ester 2-Pyrazinecarboxylic acid METHYL 5-METHYLPYRAZINE-2-CARBOXYLATE

2-(ETHOXYCARBONYL)-3-METHYLQUINOXALINEDIIUM-1,4-DIOLATE 2-(METHOXYCARBONYL)-3-METHYLQUINOXALINEDIIUM-1,4-DIOLATE methyl 3-Chloro-5-methyl-pyrazine-2-carboxylate

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