Methyl pyrazine-2-carboxylate
- CAS No.
- 6164-79-0
- Chemical Name:
- Methyl pyrazine-2-carboxylate
- Synonyms
- PYRAZINE-2-CARBOXYLIC ACID METHYL ESTER;METHYL PYRAZINOATE;METHYL PYRAZINE-2-CA;Aaptamine Impurity 9;METHYL PYRAZINECARBOXYLATE;METHYL 2-PYRAZINECARBOXYLATE;Pyrazinoic acid methyl ester;Methyl pyrazine-2-carboxylate;Pyrazinecarboxylic acid methyl;Methyl2-Pyrazinecarboxylate>
- CBNumber:
- CB5369861
- Molecular Formula:
- C6H6N2O2
- Molecular Weight:
- 138.12
- MDL Number:
- MFCD00014611
- MOL File:
- 6164-79-0.mol
- MSDS File:
- SDS
| Melting point | 57-61 °C(lit.) |
|---|---|
| Boiling point | 104°C/7mmHg(lit.) |
| Density | 1.213±0.06 g/cm3(Predicted) |
| Flash point | >100°(212°F) |
| storage temp. | Sealed in dry,Room Temperature |
| form | Liquid |
| pka | -0.91±0.10(Predicted) |
| color | Clear colorless |
| Merck | 14,7959 |
| BRN | 118345 |
| InChI | InChI=1S/C6H6N2O2/c1-10-6(9)5-4-7-2-3-8-5/h2-4H,1H3 |
| InChIKey | TWIIRMSFZNYMQE-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)=NC=CN=C1 |
| LogP | -0.230 |
| CAS DataBase Reference | 6164-79-0(CAS DataBase Reference) |
| FDA UNII | 90NZ6P9NG2 |
| EPA Substance Registry System | Pyrazinecarboxylic acid, methyl ester (6164-79-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Methyl pyrazine-2-carboxylate price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 519677 | Methyl 2-pyrazinecarboxylate 97% | 6164-79-0 | 5g | $244 | 2023-06-20 | Buy |
| TCI Chemical | M2015 | Methyl 2-Pyrazinecarboxylate >98.0%(GC) | 6164-79-0 | 5g | $87 | 2026-04-30 | Buy |
| TCI Chemical | M2015 | Methyl 2-Pyrazinecarboxylate >98.0%(GC) | 6164-79-0 | 25g | $255 | 2026-04-30 | Buy |
| Apolloscientific | OR6399 | Methyl pyrazine-2-carboxylate >97% | 6164-79-0 | 25g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR6399 | Methyl pyrazine-2-carboxylate >97% | 6164-79-0 | 100g | $79 | 2026-06-04 | Buy |
Methyl pyrazine-2-carboxylate Chemical Properties, Uses, Production
Chemical Properties
White solid
Uses
METHYL PYRAZINE-2-CARBOXYLATE is used as an intermediate for the synthesis of MOF material ligands.
Synthesis
67-56-1
98-97-5
6164-79-0
To a solution of 2-pyrazinecarboxylic acid (5.80 g, 46.5 mmol) in dichloromethane (100 mL) was slowly added oxalyl chloride (5.10 mL, 60.4 mmol), followed by the addition of a catalytic amount of DMF.The reaction mixture was stirred for 6 hr. at 23° C. The reaction was completed with the addition of methanol (30 mL). After completion of the reaction, methanol (30 mL) was added slowly and stirring was continued for 30 min. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (200 mL) and washed sequentially with saturated aqueous sodium bicarbonate (1 x 100 mL) and brine (1 x 100 mL). The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford 3.38 g (53% yield) of the crude methyl pyrazine-2-carboxylate, which could be used in the next step of the reaction without further purification.1H NMR (400 MHz, CDCl3): δ 9.34 (d, 1H), 8.79 (d, 1H), 8.74 (dd, 1H), 4.06 (s 3H); LCMS (Method A): tR = 0.48 min, m/z 139.3 (M + H)+.
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 12, p. 2843 - 2851
[2] Journal of the American Chemical Society, 1990, vol. 112, # 17, p. 6248 - 6254
[3] Patent: WO2004/48369, 2004, A1. Location in patent: Page 8
[4] Tetrahedron Letters, 2009, vol. 50, # 28, p. 4030 - 4032
[5] Patent: WO2016/207914, 2016, A2. Location in patent: Page/Page column 3; 13; 14
Methyl pyrazine-2-carboxylate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 9ding chemical ( Shanghai) Limited | 021-021-52271985 17721149837 | sales@9dingchem.com | China | 19780 | 60 |
| Henan Kehong Biological Technology Co. LTD | 0371-86658258 18638736641 | info@kehobio.com | China | 2767 | 58 |
| Suzhou Xinrui Biotechnology Co., Ltd. | 13401437572 | xinruibiotech01@163.com | China | 2738 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from Methyl pyrazine-2-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | METHYL PYRAZINE-2-CARBOXYLATE
6164-79-0
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2020-04-29 | Methyl pyrazine-2-carboxylate
6164-79-0
|
1KG | 99.0%+ | 800 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | METHYL PYRAZINE-2-CARBOXYLATE
6164-79-0
|
$8.00 | 1kg | 99% | 10tons | Career Henan Chemical Co |
-
- METHYL PYRAZINE-2-CARBOXYLATE
6164-79-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Methyl pyrazine-2-carboxylate
6164-79-0
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
-
- METHYL PYRAZINE-2-CARBOXYLATE
6164-79-0
- $8.00
- 99%
- Career Henan Chemical Co
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