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Ethyl 1-Boc-3-piperidinecarboxylate

Ethyl 1-Boc-3-piperidinecarboxylate structure

CAS No.: 130250-54-3

Chemical Name:: Ethyl 1-Boc-3-piperidinecarboxylate

Synonyms: BOC-DL-NIPC-OET;BOC-DL-PIC(3)-OET;BOC-DL-PIC(3)-EOT;ETHYL N-BOC-NIPECOTATE;1-BOC-ETHYL NIPECOTATE;Ethyl 1-Boc-nipecotate;N-BOC S-ethyl nipecotate;Ethyl N-Boc-DL-nipecotate;1-Boc-3-piperidinecarboxyL;BOC-DLChemicalbook-PIC(3)-EOT

CBNumber:: CB9454527

Molecular Formula:: C13H23NO4

Molecular Weight:: 257.33

MDL Number:: MFCD04116274

MOL File:: 130250-54-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:57:46

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Ethyl 1-Boc-3-piperidinecarboxylate Properties

Melting point	31-35℃
Boiling point	95℃/0.5mm
Density	1.077±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	-2.40±0.40(Predicted)
form	powder to lump
color	White to Yellow to Orange
Sensitive	Moisture & Light Sensitive
BRN	3614917
InChI	InChI=1S/C13H23NO4/c1-5-17-11(15)10-7-6-8-14(9-10)12(16)18-13(2,3)4/h10H,5-9H2,1-4H3
InChIKey	YCXCRFGBFZTUSU-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCCC(C(OCC)=O)C1
CAS DataBase Reference	130250-54-3(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H317-H319

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

22-36-43-52

Safety Statements

WGK Germany

HazardClass

IRRITANT

HS Code

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Sens. 1

NFPA 704

	1
2		0

Ethyl 1-Boc-3-piperidinecarboxylate price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	E0954	Ethyl 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylate >98.0%(GC)	130250-54-3	5g	$32	2026-04-30	Buy
TCI Chemical	E0954	Ethyl 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylate >98.0%(GC)	130250-54-3	25g	$92	2026-04-30	Buy
Apolloscientific	OR309162	Ethyl piperidine-3-carboxylate, N-BOC protected >98%	130250-54-3	25g	$21	2026-06-04	Buy
Apolloscientific	OR309162	Ethyl piperidine-3-carboxylate, N-BOC protected >98%	130250-54-3	100g	$28	2026-06-04	Buy
Apolloscientific	OR309162	Ethyl piperidine-3-carboxylate, N-BOC protected >98%	130250-54-3	500g	$131	2026-06-04	Buy

Product number	Packaging	Price	Buy
E0954	5g	$32	Buy
E0954	25g	$92	Buy
OR309162	25g	$21	Buy
OR309162	100g	$28	Buy
OR309162	500g	$131	Buy

Ethyl 1-Boc-3-piperidinecarboxylate Chemical Properties, Uses, Production

Synthesis

Boc₂O (7.75 mL, 33.4 mmol) was added to a solution of ethyl piperidine-3-carboxylate (15 g, 95 mmol) in THF (159 mL) at room temperature, and the mixture was stirred for 16 h at room temperature. The resulting reaction mass was diluted with water (50 mL) and then extracted with ethyl acetate (3 x 100 mL). The combined organic extract was washed with saturated NaHCO₃ solution (1 x 200 mL) and brine (20 mL), dried (Na₂SO₄), filtered, and concentrated. The resulting residue was purified by ELSD ISCO on a 120 g silica gel column, eluting the compound in hexane to approximately 25% ethyl acetate. The pure fraction was collected and concentrated to give the desired product, 1-tert-butyl-3-ethylpiperidine-1,3-dicarboxylate. The final product, ethyl Ethyl 1-Boc-3-piperidinecarboxylate, was obtained in a yield of 23.39 g, 91 mmol, 95%.

Synthetic Route of Ethyl 1-Boc-3-piperidinecarboxylate

Chemical Properties

White powder

Uses

Reactant for synthesis of:

GABAA receptor agonists
Piperidine derivatives
Selective TACE inhibitors
HDL-elevating agents
α-Sulfonyl hydroxamic acid derivatives
chemicals in the Iboga-alkaloid family

Uses

Reactant for synthesis of:• ;GABAA receptor agonists1• ;Piperidine derivatives2• ;Selective TACE inhibitors3• ;HDL-elevating agents4• ;α-Sulfonyl hydroxamic acid derivatives5• ;chemicals in the Iboga-alkaloid family6

Ethyl 1-Boc-3-piperidinecarboxylate Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Ethyl piperidine-3-carboxylate hydrochloride Ethyl nipecotate Dichloromethane Triethylamine

Preparation Products

Ethyl 1-Boc-3-piperidinecarboxylate Suppliers

Global Suppliers ( 246)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Hobor Chemical Co., Ltd	13918007836	sales@hoborchem.com	China	423	60
Anhui Dexinjia Biopharm Co., Ltd	0531-82375893 15553111391	phoebe@jndxj.com	China	285	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2776	65
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56

Supplier	Advantage
Shanghai Hobor Chemical Co., Ltd	60
Anhui Dexinjia Biopharm Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Chembest Research Laboratories Limited	61
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65
Wuhan Chemwish Technology Co., Ltd	56

View Latest Price from Ethyl 1-Boc-3-piperidinecarboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-02	Ethyl 1-Boc-3-piperidinecarboxylate 130250-54-3	$10.00-100.00	1kg	99%	5000 Metric Ton/Month	Wuhan Xinhao Biotechnology Co., Ltd
2023-11-03	Ethyl 1-Boc-3-piperidinecarboxylate 130250-54-3	$10.00	1kg	99%	100tons	Anhui Zhongda Biotechnology Co., Ltd
2023-06-26	Ethyl 1-Boc-3-piperidinecarboxylate 130250-54-3	$150.00	10g	99%	500kg/month	Hebei Mingeng Biotechnology Co., Ltd

Ethyl 1-Boc-3-piperidinecarboxylate
130250-54-3
$10.00-100.00
99%
Wuhan Xinhao Biotechnology Co., Ltd

Ethyl 1-Boc-3-piperidinecarboxylate
130250-54-3
$10.00
99%
Anhui Zhongda Biotechnology Co., Ltd

Ethyl 1-Boc-3-piperidinecarboxylate
130250-54-3
$150.00
99%
Hebei Mingeng Biotechnology Co., Ltd

Ethyl 1-Boc-3-piperidinecarboxylate Spectrum

Ethyl 1-Boc-3-piperidinecarboxylate(130250-54-3)¹HNMR

130250-54-3 (Ethyl 1-Boc-3-piperidinecarboxylate) Related Search:

tert-Butyl acetate tert-Butyl peroxyacetate Ethyl benzoylformate Urethane Ethyl cyanoformate

Ethylparaben Ethyl 4-piperidinecarboxylate Ethyl acetate Ethyl formate Cyhalofop-butyl

Ethyl nipecotate Cyclohexanecarboxylic acid ethyl ester Butyl acetate Buprofezin 2-Ethoxyethanol

Ethanol tert-Butanol DL-Nipecotic acid

1of4

1-(TERT-BUTOXYCARBONYL)-3-(ETHOXYCARBONYL)PIPERIDINE ETHYL 1-BOC-3-PIPERIDINECARBOXYLATE ETHYL N-BOC-NIPECOTATE BOC-DL-NIPC-OET BOC-DL-PIC(3)-EOT BOC-DL-PIC(3)-OET N-T-BUTOXYCARBONYL-DL-NIPECOTIC ACID ETHYL ESTER N-T-BUTOXYCARBONYL-DL-PIPERIDINECARBOXYLIC ACID ETHYL ESTER N-T-BUTOXYCARBONYL-DL-3-PIPERIDINECARBOXYLIC ACID ETHYL ESTER N-T-BUTOXYCARBONYL-(R,S)-PIPERIDINE-3-CARBOXYLIC ACID ETHYL ESTER N-T-BUTOXYCARBONYL-(R,S)-NIPECOTIC ACID ETHYL ESTER N-T-BUTOXYCARBONYL-(R,S)-NIPOCITUC ACID ETHYL ESTER N-T-BUTOXYCARBONYL-(+/-)-NIPECOTIC ACID ESTER N-T-BUTOXYCARBONYL-(+/-)-NIPECOTIC ACID ETHYL ESTER PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-ETHYL ESTER 1-Boc-3-Piperidinecarboxylic acid ethyl ester 1-BOC-ETHYL NIPECOTATE 1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester 1-(tert-butyl) 3-ethyl tetrahydro-1,3(2H)-pyridinedicarboxylate 1-(tert-Butyl) 3-ethyl 1,3-piperidinedicarboxylate 1-Boc-3-piperidinecarboxylate ethyl ester 1-Boc-piperidine-3-carboxylic acid ethyl ester N-Boc-3-piperidinecarboxylate ethyl ester 1-(tert-Butoxycarbonyl)-piperidine-3-carboxylic acid ethyl ester Ethyl N-Boc-DL-nipecotate N-Boc-DL-nipecotic acid ethyl ester 1-tert-butyl 3-ethyl piperidine-1,3-dicarboxylate 1-Boc-nipecotic acid ethyl ester, 97% Ethyl N-Boc-3-piperidinecarboxylate Ethyl 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylate N-Boc-Piperidine-3-carboxylate or ethyl 1-Boc-piperidine-3-carboxylate N-Boc-piperidine-3-carboxylic acid ethyl ester Piperidine-1,3-dicarboxylic acid 1-tert-butyl 3-ethyl ester Ethyl 1-Boc-DL-nipecotate, 97% N-BOC-3-piperidine forMic acid ethyl ester 1-Boc-piperidine-3-carboxylic acid ethyl eater Piperidine derivative CAS NO.130250-54-3 Ethyl-N-BOC-piperidine-3-carboxylate Piperidine derivative Ethyl-N-BOC-piperidine-3-carboxylate Ethyl1-(tert-Butoxycarbonyl)-3-piperidinecarboxylate> N-BOC S-ethyl nipecotate 1-Boc-3-piperidinecarboxyL N-Boc-piperidine-3-carboxylate, ethyl ester 1-(tert-Butoxycarbonyl)-3-piperidinecarboxylic Acid Ethyl Ester 1-(tert-Butoxycarbonyl)nipecotic Acid Ethyl Es Ethyl 1-(tert-Butoxycarbonyl)nipecotate Ethyl 1-Boc-nipecotate BOC-DLChemicalbook-PIC(3)-EOT Piperidine-1,3-dicarboxylic acid 1-tert-butyl 3-ethyl Ethyl N-Boc-piperidine-3-carboxylate N-Boc-3-piperidinecarboxylic acid ethyl ester Ethyl piperidine-3-carboxylate, N-BOC protected 1-tert-Butyl 3-ethyl piperidin-1,3-dicarboxylate 130250-54-3 Building Blocks C13 Chemical Synthesis Heterocyclic Building Blocks Piperidines