2,6-Dichloro-4-methylnicotinonitrile
- CAS No.
- 875-35-4
- Chemical Name:
- 2,6-Dichloro-4-methylnicotinonitrile
- Synonyms
- 2,6-DICHLORO-3-CYANO-4-METHYLPYRIDINE;2,6-DICHLORO-4-METHYLPYRIDINE-3-CARBONITRILE;001.01.0121;BUTTPARK 43\57-14;IFLAB-BB F0907-8363;2,6-Dichloro-4-methy;3-Cyano-2,6-dichloro-4-methyl;3-Cyano-2,6-dichloro-GAMMA-picoline;3-Cyano-2,6-Chloro-4-methylpyridine;2,6-DICHLORO-4-METHYLNICOTINONITRILE
- CBNumber:
- CB9458969
- Molecular Formula:
- C7H4Cl2N2
- Molecular Weight:
- 187.03
- MDL Number:
- MFCD00052633
- MOL File:
- 875-35-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 108-112 °C(lit.) |
|---|---|
| Boiling point | 118 °C / 5mmHg |
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | 0.4g/l |
| pka | -4.53±0.10(Predicted) |
| form | solid |
| PH | 3.5 (H2O, 20℃)(aqueous suspension) |
| Appearance | White to light brown Solid |
| InChI | InChI=1S/C7H4Cl2N2/c1-4-2-6(8)11-7(9)5(4)3-10/h2H,1H3 |
| InChIKey | LSPMHHJCDSFAAY-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(Cl)=CC(C)=C1C#N |
| CAS DataBase Reference | 875-35-4(CAS DataBase Reference) |
| FDA UNII | C46NGD2HM7 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H312+H332-H315-H317-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P310-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 20/21-25-37/38-41-43-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-45-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Eye Dam. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
|||||||||
| REACH Registrations | Inactive | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2,6-Dichloro-4-methylnicotinonitrile price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 643521 | 2,6-Dichloro-4-methylnicotinonitrile 97% | 875-35-4 | 25g | $260 | 2026-04-30 | Buy |
| Sigma-Aldrich | 643521 | 2,6-Dichloro-4-methylnicotinonitrile 97% | 875-35-4 | 5g | $79.8 | 2023-06-20 | Buy |
| TCI Chemical | D3346 | 2,6-Dichloro-3-cyano-4-methylpyridine >98.0%(GC) | 875-35-4 | 5g | $49 | 2026-04-30 | Buy |
| TCI Chemical | D3346 | 2,6-Dichloro-3-cyano-4-methylpyridine >98.0%(GC) | 875-35-4 | 25g | $83 | 2026-04-30 | Buy |
| Usbiological | 274219 | 2,6-Dichloro-4-methylnicotinonitrile Asreported | 875-35-4 | 50g | $379 | 2026-06-03 | Buy |
2,6-Dichloro-4-methylnicotinonitrile Chemical Properties, Uses, Production
Chemical Properties
White to light brown powder
Uses
2,6-Dichloro-4-methylnicotinonitrile is a pharmaceutical intermediate compound of Nevirapine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of human immunodeficiency virus (HIV).
Synthesis
5444-02-0
875-35-4
General procedure for the synthesis of 3-cyano-4-methyl-2,6-dichloropyridine from 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile: 6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (28.0 g, 195.2 mmol) was dissolved in phosphorus triclosan (60.0 mL). The reaction mixture was transferred to a pressure tube, sealed and heated to 180 °C for 6 hours. Upon completion of the reaction, it was cooled to room temperature and excess phosphorous trichloride was removed by distillation under reduced pressure. Crushed ice was slowly added to the residue and a solid was precipitated. The solid was collected by filtration and dried under vacuum to afford the target product 3-cyano-4-methyl-2,6-dichloropyridine in 92% yield without further purification.
References
[1] Journal of Heterocyclic Chemistry, 1995, vol. 32, # 3, p. 979 - 984
[2] Patent: WO2014/165232, 2014, A1. Location in patent: Paragraph 0174; 0175
[3] Patent: US2015/119387, 2015, A1. Location in patent: Paragraph 0175; 0176
[4] Patent: JP2017/95498, 2017, A. Location in patent: Paragraph 0079; 0080
[5] Patent: CN104530042, 2017, B. Location in patent: Paragraph 0171; 0177; 0178; 0179
2,6-Dichloro-4-methylnicotinonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Yuzhiquan Biological Technology Co., Ltd. | 18306022109 | 3236923470@qq.com | China | 283 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 2,6-Dichloro-4-methylnicotinonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-12 | 2,6-Dichloro-4-methylnicotinonitrile
875-35-4
|
25kg | 99%min | 10 tons | Hangzhou Verychem Science And Technology Co.Ltd | ||
 |
2025-06-25 | 2,6-Dichloro-4-methylnicotinonitrile
875-35-4
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2022-02-19 | 2,6-Dichloro-4-methylnicotinonitrile
875-35-4
|
1KG | 98.0% | 100 tons | Honest Joy Holdings Limited |
-
- 2,6-Dichloro-4-methylnicotinonitrile
875-35-4
- 99%min
- Hangzhou Verychem Science And Technology Co.Ltd
-
- 2,6-Dichloro-4-methylnicotinonitrile
875-35-4
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 2,6-Dichloro-4-methylnicotinonitrile
875-35-4
- $0.00
- 98.0%
- Honest Joy Holdings Limited
