Methyl cyanoacetate
- CAS No.
- 105-34-0
- Chemical Name:
- Methyl cyanoacetate
- Synonyms
- Methyl 2-cyanoacetate;2-cyanopropanoate;CYANOACETIC ACID METHYL ESTER;MCYA;usafkf-22;USAF kf-22;25KG,100KG,1T;Methylcyanacetat;Methyl Cyanoacetat;METHYL CYANOACETATE
- CBNumber:
- CB9485583
- Molecular Formula:
- C4H5NO2
Lewis structure
- Molecular Weight:
- 99.09
- MDL Number:
- MFCD00001939
- MOL File:
- 105-34-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl cyanoacetate 99% | 108421 | 25g | $63.1 |
| Methyl cyanoacetate 99% | 108421 | 2kg | $209 |
| Methyl Cyanoacetate >99.0%(GC) | C0442 | 25mL | $34 |
| Methyl Cyanoacetate >99.0%(GC) | C0442 | 500mL | $76 |
| Methyl cyanoacetate 99% | 108421 | 500g | $107 |
| More product size | |||
| Melting point | -13 °C |
|---|---|
| Boiling point | 204-207 °C(lit.) |
| Density | 1.123 g/mL at 25 °C(lit.) |
| vapor density | 3.41 (vs air) |
| vapor pressure | 0.2 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 54g/l |
| pka | 2.75±0.10(Predicted) |
| form | Liquid |
| color | Clear colorless to very slightly yellow |
| Water Solubility | 54 g/L (20 ºC) |
| Sensitive | Light Sensitive |
| BRN | 773945 |
| Henry's Law Constant | 3.5×101 mol/(m3Pa) at 25℃, Ebert et al. (2023) |
| Dielectric constant | 29.4（21℃） |
| InChI | 1S/C4H5NO2/c1-7-4(6)2-3-5/h2H2,1H3 |
| InChIKey | ANGDWNBGPBMQHW-UHFFFAOYSA-N |
| SMILES | COC(=O)CC#N |
| LogP | -0.47 at 25℃ |
| CAS DataBase Reference | 105-34-0(CAS DataBase Reference) |
| FDA UNII | A28RI36V30 |
| NIST Chemistry Reference | Acetic acid, cyano-, methyl ester(105-34-0) |
| EPA Substance Registry System | Acetic acid, cyano-, methyl ester (105-34-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| PPE | Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | AG4375000 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29269095 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| Toxicity | guinea pig,LDLo,skin,400mg/kg (400mg/kg),"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 920, 1986. | |||||||||
| NFPA 704 |
|
Methyl cyanoacetate price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 108421 | Methyl cyanoacetate 99% | 105-34-0 | 25g | $63.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 108421 | Methyl cyanoacetate 99% | 105-34-0 | 2kg | $209 | 2023-06-20 | Buy |
| TCI Chemical | C0442 | Methyl Cyanoacetate >99.0%(GC) | 105-34-0 | 25mL | $34 | 2026-04-30 | Buy |
| TCI Chemical | C0442 | Methyl Cyanoacetate >99.0%(GC) | 105-34-0 | 500mL | $76 | 2026-04-30 | Buy |
| Sigma-Aldrich | 108421 | Methyl cyanoacetate 99% | 105-34-0 | 500g | $107 | 2026-04-30 | Buy |
Methyl cyanoacetate Chemical Properties,Uses,Production
Description
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds. It is often used as a nucleophile in the electrochemical oxidation of catechols. Methyl Cyanoacetate is also a reagent in the synthesis of Methyl 2-Amino-4-trifluoromethylthiophene-3-carboxylate; a compound used in the synthesis of DPP-IV inhibitors for treating type-2 diabetes. In addition, it is an intermediate in the preparation of α-cyanoacrylate, malononitrile, and 1,1-cyclohexanediacetic acid dyes. It is used as UV absorber or stabilizer, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.
Chemical Properties
clear colorless to very slighlty yellow liquid
Uses
pharmaceutical intermediate
Uses
Methyl cyanoacetate is an intermediate in the preparation of α-cyanoacrylate, malononitrile, 1,1-cyclohexanediacetic acid dye. It is used as UV absorber or stabiliser, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.
Definition
ChEBI: Methyl cyanoacetate is an alkyl cyanoacetate ester.
General Description
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Knvenagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α-cyanocinnamic esters.
Synthesis
67-56-1
372-09-8
105-34-0
GENERAL METHOD: A mixture of cyanoacetic acid, methanol and N-bromosuccinimide was placed in a 25 mL reaction tube and the reaction was stirred at 70°C for 2-40 hours. Upon completion of the reaction, the reaction mixture is cooled to room temperature and subsequently evaporated under reduced pressure to remove methanol. Unless otherwise stated in Section 3.2.6, the subsequent isolation and purification steps were as follows: the residue was dissolved in ethyl acetate and washed sequentially with 10 mL of 10% aqueous Na2S2O3 solution, 5 mL of saturated aqueous NaHCO3 solution and 10 mL of distilled water. The aqueous phase was back-extracted with ethyl acetate (3 x 5 mL). All organic layers were combined, dried with anhydrous Na2SO4 and finally evaporated under reduced pressure to remove the solvent.
Purification Methods
Purify the ester by shaking with 10% Na2CO3 solution, wash well with water, dry with anhydrous Na2SO4, and distil it. [Beilstein 2 H 584, 2 I 253, 2 II 530, 2 III 1628, 2 IV 1889.]
References
[1] Synthesis, 1980, # 7, p. 547 - 551
[2] Molecules, 2018, vol. 23, # 9,
[3] Synthetic Communications, 1988, vol. 18, # 8, p. 847 - 854
[4] Patent: US2553065, 1949,
[5] Tetrahedron Letters, 1998, vol. 39, # 47, p. 8563 - 8566
Methyl cyanoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
1of5
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Sinoda Biological Technology Co., Ltd | +8613401983379 | sales@njmcn.cn | CHINA | 74 | 58 |
| Ningbo Banco Chemical Technology Co., Ltd. | +86-15827200700 | sales@bancochemical.com | China | 487 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21590 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1001 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
View Lastest Price from Methyl cyanoacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-30 | Methyl cyanoacetate
105-34-0
|
US $0.00 / KG | 1KG | 99.5% | 500mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-03-20 | Methyl cyanoacetate
105-34-0
|
US $1.00 / kg | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-05-26 | Methyl Cyanoacetate
105-34-0
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Methyl cyanoacetate
105-34-0
- US $0.00 / KG
- 99.5%
- Jinan Finer Chemical Co., Ltd
-
- Methyl cyanoacetate
105-34-0
- US $1.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Methyl Cyanoacetate
105-34-0
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
