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4-Amino-6-chloropyrimidine

4-Amino-6-chloropyrimidine structure

CAS No.: 5305-59-9

Chemical Name:: 4-Amino-6-chloropyrimidine

Synonyms: H50551;NSC 42134;4-Amino-6-chL;4-Amino-6-chloropyri;6-Chloro-4-pyrimidinamine;6-Chloropyrimidin-4-amine;6-Chloropyrimidine-4-amine;6-AMino-4-chloropyriMidine;2-CHLORO-6-AMINOPYRIMIDINE;4-AMINO-6-CHLOROPYRIMIDINE

CBNumber:: CB4424750

Molecular Formula:: C4H4ClN3

Molecular Weight:: 129.55

MDL Number:: MFCD00053576

MOL File:: 5305-59-9.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:51

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4-Amino-6-chloropyrimidine Properties

Melting point	215-216°C
Boiling point	289.0±20.0 °C(Predicted)
Density	1.437±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO
pka	2.16±0.10(Predicted)
form	Solid
color	Pale Yellow
InChI	InChI=1S/C4H4ClN3/c5-3-1-4(6)8-2-7-3/h1-2H,(H2,6,7,8)
InChIKey	DUKKRSPKJMHASP-UHFFFAOYSA-N
SMILES	C1=NC(Cl)=CC(N)=N1
CAS DataBase Reference	5305-59-9(CAS DataBase Reference)
FDA UNII	99CMM8EZ3Q
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-22

Safety Statements

26-36/37/39-36/37

WGK Germany

Hazard Note

Harmful

HazardClass

IRRITANT

HS Code

29335990

NFPA 704

	0
2		0

4-Amino-6-chloropyrimidine price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	735272	4-Amino-6-chloropyrimidine 97%	5305-59-9	1g	$47.9	2023-06-20	Buy
TCI Chemical	A2136	4-Amino-6-chloropyrimidine >98.0%(GC)(T)	5305-59-9	1g	$43	2025-07-31	Buy
TCI Chemical	A2136	4-Amino-6-chloropyrimidine >98.0%(GC)(T)	5305-59-9	5g	$126	2025-07-31	Buy
Usbiological	A1376-61	4-Amino-6-chloropyrimidine	5305-59-9	2g	$389	2021-12-16	Buy
AK Scientific	J97012	4-Amino-6-chloropyrimidine	5305-59-9	500g	$420	2021-12-16	Buy

Product number	Packaging	Price	Buy
735272	1g	$47.9	Buy
A2136	1g	$43	Buy
A2136	5g	$126	Buy
A1376-61	2g	$389	Buy
J97012	500g	$420	Buy

4-Amino-6-chloropyrimidine Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Anticancer Research

4-Amino-6-chloropyrimidine has been shown to inhibit the proliferation of cancer cells in vitro and in vivo, without affecting normal cells. 4-Amino-6-chloropyrimidine also inhibits kinase activity and protein synthesis in cancer cells. This drug has a potent inhibitory effect on cell proliferation.

Synthesis

1193-21-1

5305-59-9

The general procedure for the synthesis of 4-amino-6-chloropyrimidine from 4,6-dichloropyrimidine was as follows: to a suspension of 4,6-dichloropyrimidine (3.0 g, 20 mmol) in isopropanol (40 mL) was slowly added the appropriate amine, with the rate of addition being controlled so as to maintain the internal temperature of the reaction system at no more than 40°C. The reaction mixture was stirred continuously for 1 hour at 25°C. After addition, the reaction mixture was stirred continuously at 25 °C for 1 hour. Upon completion of the reaction, water (30 mL) was added and the resulting suspension was cooled to 0 °C in an ice bath. The precipitated product was collected by filtration and washed sequentially with pre-cooled isopropanol/water solvent mixture (V/V=2:1, 50 mL) and pure water. Finally, the resulting solid product was dried under vacuum to obtain the target compound 4-amino-6-chloropyrimidine.

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 20, p. 7066 - 7083
[2] European Journal of Medicinal Chemistry, 2014, vol. 75, p. 11 - 20
[3] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 84
[4] Patent: US2012/15943, 2012, A1. Location in patent: Page/Page column 54
[5] ChemMedChem, 2017, vol. 12, # 16, p. 1390 - 1398

4-Amino-6-chloropyrimidine Preparation Products And Raw materials

Raw materials

Acetamide Methyl propionate Methyl cyanoacetate 4,6-Dichloropyrimidine Ammonia

Isopropyl alcohol

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Preparation Products

4-Amino-6-methoxypyrimidine 6-(PYRIDIN-3-YL)PYRIMIDIN-4-AMINE 4-Pyrimidinamine, 6-(1-ethoxyethenyl)- N4-butyl-pyrimidine-4,6-diyldiamine 4-Pyrimidinamine, 6-(2-ethoxyphenyl)-

N-(6-ChloropyriMidin-4-yl)acetaMide 6-(3-Methoxyphenyl)pyrimidin-4-amine Pyrimidine, 4-(allylamino)-6-amino- (6CI)

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4-Amino-6-chloropyrimidine Suppliers

Global( 400)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58

View Lastest Price from 4-Amino-6-chloropyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-08	4-Amino-6-chloropyrimidine 5305-59-9	US $0.00 / Kg/Drum	1Kg/Drum	99%	5000KG	Hebei Mujin Biotechnology Co.,Ltd
2025-04-04	4-Amino-6-chloropyrimidine 5305-59-9	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2021-07-13	4-Amino-6-chloropyrimidine 5305-59-9	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

4-Amino-6-chloropyrimidine
5305-59-9
US $0.00 / Kg/Drum
99%
Hebei Mujin Biotechnology Co.,Ltd

4-Amino-6-chloropyrimidine
5305-59-9
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

4-Amino-6-chloropyrimidine
5305-59-9
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4-Amino-6-chloropyrimidine Spectrum

4-Amino-6-chloropyrimidine(5305-59-9)¹HNMR 4-Amino-6-chloropyrimidine(5305-59-9)FT-IR

5305-59-9(4-Amino-6-chloropyrimidine)Related Search:

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4-Chloro-2,6-diaminopyrimidine 6-CHLORO-5-NITROPYRIMIDIN-4-AMINE N1-(3-[(2,5,6-TRICHLOROPYRIMIDIN-4-YL)AMINO]PHENYL)-4-METHYLBENZAMIDE

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4-AMINO-6-CHLOROPYRIMIDINE 6-CHLORO-PYRIMIDIN-4-YLAMINE 4-Pyrimidinamine, 6-chloro- (9CI) 2-CHLORO-6-AMINOPYRIMIDINE 6-Chloro-4-pyrimidinamine 6-CHLORO-PYRIMIDIN-4-YLAMINE 98% 6-Chloropyrimidin-4-amine NSC 42134 6-AMino-4-chloropyriMidine 6-Chloropyrimidine-4-amine 4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)benzene-1-sulfonyl chloride 6-chloro-4-aminopyrimidine 4-Amino-6-chloropyri 6-Chloropyrimidin-4-amine, 4-Amino-6-chloro-1,3-diazine 4-Chloro-6-aminopyrimidine 4-AMino-6-chloropyriMidine, 98%, 98% 4-Amino-6-chloropyrimidine 97% H50551 4-Amino-6-chloropyrimidine > 4-Amino-6-chL 4-Pyrimidinamine, 6-chloro- 5305-59-9 C4H4ClN3 AMINE chloropyrimidin Heterocycle-Pyrimidine series amine| alkyl chloride Biochemistry Nucleobases and their analogs Nucleosides, Nucleotides & Related Reagents Bases & Related Reagents Nucleotides Nucleotides and Nucleosides Pyrimidines Amines and Anilines Heterocycles PYRIMIDINE Heterocycles Nucleotides Amines bc0001