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F-1

F-1 Structure
F-1 structure
CAS No.
2244775-31-1
Chemical Name:
F-1
Synonyms
F-1, 10 mM in DMSO;N-{2-[(5-chloro-2-{[2-methoxy-6-(4-methylpiperazin-1-yl)pyridin-3-yl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide;Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]-;ALK tyrosine kinase receptor,CD246,Anaplastic lymphoma kinase (ALK),F-1,Anaplastic lymphoma kinase,Inhibitor,F1,ROS Kinase,Cluster of differentiation 246,F 1,inhibit
CBNumber:
CB94921799
Molecular Formula:
C22H27ClN8O3S
Molecular Weight:
519.02
MDL Number:
MFCD32068346
MOL File:
2244775-31-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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F-1 Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color White to off-white

F-1 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth UPD77531 F-1 2244775-31-1 25mg $1207.25 2026-06-05 Buy
Biosynth UPD77531 F-1 2244775-31-1 50mg $1679 2026-06-05 Buy
Biosynth UPD77531 F-1 2244775-31-1 100mg $2687 2026-06-05 Buy
ChemScene CS-0065714 F-1 98.03% 2244775-31-1 5mg $314 2026-06-04 Buy
ChemScene CS-0065714 F-1 98.03% 2244775-31-1 10mg $455 2026-06-04 Buy
Product number Packaging Price Buy
UPD77531 25mg $1207.25 Buy
UPD77531 50mg $1679 Buy
UPD77531 100mg $2687 Buy
CS-0065714 5mg $314 Buy
CS-0065714 10mg $455 Buy

F-1 Chemical Properties, Uses, Production

Uses

F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways, with IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively[1].

References

[1] Guo M, et al. Dual potent ALK and ROS1 inhibitors combating drug-resistant mutants: Synthesis and biological evaluation of aminopyridine-containing diarylaminopyrimidine derivatives. Eur J Med Chem. 2018 Sep 6;158:322-333. DOI:10.1016/j.ejmech.2018.09.012

F-1 Preparation Products And Raw materials

Raw materials

Preparation Products

F-1 Suppliers

Global Suppliers ( 25)
Supplier Tel Email Country ProdList Advantage
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Shanghai Dongyang Biotechnology Co., Ltd. 0512-13601744364 13601744364 chemsharker@126.com China 1162 58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 13611835272 13611835272 mmwang@sunwaypharm.com China 44090 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Supplier Advantage
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Shanghai Dongyang Biotechnology Co., Ltd. 58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Latest Price from F-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
F-1 pictures 2026-07-27 F-1
2244775-31-1
 $40.00-119.00 99.50% 10g TargetMol Chemicals Inc.
F-1 pictures 2026-07-27 F-1
2244775-31-1
 $40.00-119.00 99.50% 10g TargetMol Chemicals Inc.
  • F-1 pictures
  • F-1
    2244775-31-1
  • $40.00-119.00
  • 99.50%
  • TargetMol Chemicals Inc.
  • F-1 pictures
  • F-1
    2244775-31-1
  • $40.00-119.00
  • 99.50%
  • TargetMol Chemicals Inc.

F-1 Spectrum

F-1(2244775-31-1)1HNMR

2244775-31-1 (F-1) Related Search:

F-1 1H-Pyrazole-3-carboxylic acid, 5-hydroxy-1-[3-(trifluoromethyl)phenyl]- NVP-TAE684 Protein Tyrosine Kinase Compound Library Anti-cancer compound library
Crizotinib

1of2

Methanesulfonamide, N-[2-[[5-chloro-2-[[2-methoxy-6-(4-methyl-1-piperazinyl)-3-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]- ALK tyrosine kinase receptor,CD246,Anaplastic lymphoma kinase (ALK),F-1,Anaplastic lymphoma kinase,Inhibitor,F1,ROS Kinase,Cluster of differentiation 246,F 1,inhibit N-{2-[(5-chloro-2-{[2-methoxy-6-(4-methylpiperazin-1-yl)pyridin-3-yl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide F-1, 10 mM in DMSO 2244775-31-1 C22H27ClN8O3S