AMITRIPTYLINE METABOLITE (+/-)-
- CAS No.
- 64520-05-4
- Chemical Name:
- AMITRIPTYLINE METABOLITE (+/-)-
- Synonyms
- 10-Hydroxy (E)-Amitriptyline;AMITRIPTYLINE METABOLITE (+/-)-;(E)-10-Hydroxy amitriptyline;AMITRIPTYLINE METABOLITE (+-)-(E)-10-HYD ROXYLA;Amitriptyline metabolite, (±)-E-10-hydroxylated-;(E)-5-(3-(Dimethylamino)propylidene)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-10-ol;5H-Dibenzo[a,d]cyclohepten-10-ol, 5-[3-(dimethylamino)propylidene]-10,11-dihydro-, (5E)-;(11E)-11-[3-(dimethylamino)propylidene]-5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-5-ol
- CBNumber:
- CB9496952
- Molecular Formula:
- C20H23NO
- Molecular Weight:
- 293.4
- MDL Number:
- MFCD00069200
- MOL File:
- 64520-05-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 97-99 °C |
|---|---|
| Boiling point | 453.3±45.0 °C(Predicted) |
| Density | 1.151±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | 0.1 M HCl: soluble |
| form | solid |
| pka | 13.89±0.20(Predicted) |
| color | white |
| Stability | Hygroscopic |
| InChI | 1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12+ |
| InChIKey | GHWBJXOKAFHZAI-SFQUDFHCSA-N |
| SMILES | CN(C)CC\C=C1/c2ccccc2CC(O)c3ccccc13 |
| FDA UNII | 8646K54I21 |
| EPA Substance Registry System | 5H-Dibenzo[a,d]cyclohepten-10-ol, 5-[3-(dimethylamino)propylidene]-10,11-dihydro-, (5E)- (64520-05-4) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
AMITRIPTYLINE METABOLITE (+/-)- price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A115 | Amitriptyline metabolite, (±)-E-10-hydroxylated- analytical standard | 64520-05-4 | 2mg | $330 | 2026-04-30 | Buy |
| TRC | TRC-D462790-25MG | 10-Hydroxy (E)-Amitriptyline | 64520-05-4 | 25mg | $4791 | 2026-06-03 | Buy |
| TRC | TRC-D462790-10MG | 10-Hydroxy (E)-Amitriptyline | 64520-05-4 | 10mg | $2171 | 2026-06-03 | Buy |
| Biosynth | FH178735 | (E)-10-Hydroxyamitriptyline | 64520-05-4 | 0.5mg | $900 | 2026-06-04 | Buy |
| Biosynth | FH178735 | (E)-10-Hydroxyamitriptyline | 64520-05-4 | 2mg | $900 | 2026-06-04 | Buy |
AMITRIPTYLINE METABOLITE (+/-)- Chemical Properties, Uses, Production
Uses
(5E)-5-[3-(dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol is a metabolite of amitriptyline (A633350) which is a dibenzocycloheptadiene derivative and an antidepressant (1). Amitriptyline is also a TrkA and TrkB receptor agonist and exhibits neurotrophic and anti-inflammatory activities (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA).
Definition
ChEBI: E-10-Hydroxyamitriptyline is an organic tricyclic compound.
Biochem/physiol Actions
Metabolite of amitriptyline, tricyclic antidepressant; chromatographic standard.
AMITRIPTYLINE METABOLITE (+/-)- Preparation Products And Raw materials
Raw materials
Preparation Products
AMITRIPTYLINE METABOLITE (+/-)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai ring qi biological technology co., LTD | 13524106587 | sales@hq-chem.com | China | 242 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 17717235263 | offer.de@lgcgroup.com | China | 38135 | 58 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
| Shanghai ring qi biological technology co., LTD | 58 |
| LGC Science (Shanghai) Ltd. | 58 |
