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ChemicalBook >> CAS DataBase List >>4-Amino-2-chloropyridine, N-Boc protected 98

4-Amino-2-chloropyridine, N-Boc protected 98

4-Amino-2-chloropyridine, N-Boc protected 98 Structure
4-Amino-2-chloropyridine, N-Boc protected 98 structure
CAS No.
234108-73-7
Chemical Name:
4-Amino-2-chloropyridine, N-Boc protected 98
Synonyms
4-(Boc-amino)-2-chloropyridine;4-(Boc-aMino)-2-chloropyr...;N-Boc-2-chloro-4-pyridinamine;N-BOC PROTECTED 4-AMINO-2-CHLOROPYRIDINE;tert-Butyl 2-chloropyridin-4-ylcarbamate;4-Amino-2-chloropyridine, 4-BOC protected;ert-butylN-(2-chloropyridin-4-yl)carbamate;tert-butyl N-(2-chloropyridin-4-yl)carbamate;4-Amino-2-chloropyridine, N-Boc protected 98;4-Amino-2-chloropyridine, N-BOC protected 98%
CBNumber:
CB9501333
Molecular Formula:
C10H13ClN2O2
Molecular Weight:
228.68
MDL Number:
MFCD07781158
MOL File:
234108-73-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:56:31
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4-Amino-2-chloropyridine, N-Boc protected 98 Properties

Melting point 173-175
Boiling point 282.2±25.0 °C(Predicted)
Density 1.245±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 11.97±0.70(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Hazard Note  Irritant
HS Code  2933399990
NFPA 704
1
2 0

4-Amino-2-chloropyridine, N-Boc protected 98 price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 081250 tert-Butyl 2-chloropyridin-4-ylcarbamate 234108-73-7 1.00g $139 2026-05-18 Buy
Matrix Scientific 081250 tert-Butyl 2-chloropyridin-4-ylcarbamate 234108-73-7 10.00g $924 2026-05-18 Buy
Synthonix A1749 4-(Boc-amino)-2-chloropyridine 97.0% 234108-73-7 100mg $17 2026-05-06 Buy
Synthonix A1749 4-(Boc-amino)-2-chloropyridine 97.0% 234108-73-7 1g $28 2026-05-06 Buy
Synthonix A1749 4-(Boc-amino)-2-chloropyridine 97.0% 234108-73-7 5g $30 2026-05-06 Buy
Product number Packaging Price Buy
081250 1.00g $139 Buy
081250 10.00g $924 Buy
A1749 100mg $17 Buy
A1749 1g $28 Buy
A1749 5g $30 Buy

4-Amino-2-chloropyridine, N-Boc protected 98 Chemical Properties, Uses, Production

Uses

tert-Butyl (2-Chloropyridin-4-yl)carbamate is a reactant in the preparation of inter-domain stabilizers for allosteric Akt inhibitors.

Synthesis

4-Amino-2-chloropyridine

14432-12-3

Di-tert-butyl dicarbonate

24424-99-5

4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98

234108-73-7

General procedure for the synthesis of tert-butyl 2-chloropyridine-4-carbamate from 2-chloro-4-aminopyridine and di-tert-butyl dicarbonate: In the presence of 95 mg of 4-dimethylaminopyridine (DMAP), 1.69 g (7.78 mmol, 1 eq.) of di-tert-butyl dicarbonate was dissolved in 50 mL of dichloromethane, and slowly added to a 30 mL solution of dichloromethane containing 1 g (7.78 mmol, 1 eq.) of 2-chloro-4-aminopyridine and 1.19 mL (1.19 mmol, 1.1 eq.) of triethylamine in 30 mL of dichloromethane. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of 100 mL of water and subsequently extracted with dichloromethane. The organic phases were combined and dried over anhydrous sodium sulfate. After evaporation of the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluent ratio varied from 70/30 to 50/50 heptane/ethyl acetate gradient). The resulting oil was crystallized from pentane to give 1.40 g tert-butyl 2-chloropyridine-4-carbamate in 80% yield.

References

[1] Patent: WO2006/53791, 2006, A2. Location in patent: Page/Page column 49-50
[2] Tetrahedron Letters, 2014, vol. 55, # 49, p. 6734 - 6737
[3] Patent: WO2005/33072, 2005, A2. Location in patent: Page/Page column 26
[4] Patent: WO2004/43926, 2004, A1. Location in patent: Page 161
[5] Patent: US2004/102450, 2004, A1. Location in patent: Page/Page column 100

4-Amino-2-chloropyridine, N-Boc protected 98 Preparation Products And Raw materials

Raw materials

4-Amino-2-chloropyridine Di-tert-butyl dicarbonate Triethylamine Dichloromethane

Preparation Products

4-Amino-2-chloropyridine, N-Boc protected 98 Suppliers

Global Suppliers ( 113)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Tetranov Biopharm 64
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
T&W GROUP 58
Chiba Pharmaceutical Science and technology Co, Ltd. 55

View Latest Price from 4-Amino-2-chloropyridine, N-Boc protected 98 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98 pictures 2019-07-06 4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98
234108-73-7
 $1.00 1kg 98% 200KG Career Henan Chemical Co

4-Amino-2-chloropyridine, N-Boc protected 98 Spectrum

4-AMINO-2-CHLOROPYRIDINE, N-BOC PROTECTED 98(234108-73-7)1HNMR

234108-73-7 (4-Amino-2-chloropyridine, N-Boc protected 98) Related Search:

tert-Butyl carbamate 4-Amino-2-chloropyridine 4-(Boc-amino)pyridine tert-butyl 2-chloro-5-nitropyridin-4-ylcarbamate 4-Amino-2-chloropyridine, N-Boc protected 98
Carbamic acid, (2,6-dichloro-4-pyridinyl)-, 1,1-dimethylethyl ester (9CI)

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4-Amino-2-chloropyridine, 4-BOC protected N-Boc-2-chloro-4-pyridinamine 4-Amino-2-chloropyridine, 4-BOC protected 98% 4-(Boc-aMino)-2-chloropyr... N-tert-butyl-N-(2-chloropyridin-3-yl)carbaMate tert-butyl 2-chloropyridin-4-ylcarbaMate Molecular tert-Butyl (2-chloropyridin-4-yl)carbamate, 2-Chloro-4-(tert-butoxycarbonyl)pyridine tert-butyl N-(2-chloropyridin-4-yl)carbamate N-(2-chloro-4-pyridinyl)carbamic acid tert-butyl ester 4-Amino-2-chloropyridine, N-BOC protected 98% Carbamic acid, N-(2-chloro-4-pyridinyl)-, 1,1-dimethylethyl ester N-BOC PROTECTED 4-AMINO-2-CHLOROPYRIDINE tert-Butyl 2-chloropyridin-4-ylcarbamate ert-butylN-(2-chloropyridin-4-yl)carbamate 4-(Boc-amino)-2-chloropyridine 4-Amino-2-chloropyridine, N-Boc protected 98 234108-73-7 Amines blocks Pyridines Pyridine series