4-(Boc-amino)pyridine
- CAS No.
- 98400-69-2
- Chemical Name:
- 4-(Boc-amino)pyridine
- Synonyms
- 4-(BOC-AMINO)PYRIDINE;N-BOC-4-AMINO-PYRIDINE;BOC-N-4-AMINO-PYRIDINE;Linagliptin Impurity 76;4-(Boc-amino)pyridine ,97%;tert-Butyl 4-pyridylcarbamate;N-(4-pyridyl) t-butyl carbamate;tert-Butyl N-(4-Pyridyl)carbamate;TERT-BUTYL (PYRIDIN-4-YL)CARBAMATE;tert-butyl N-(pyridin-4-yl)carbaMate
- CBNumber:
- CB6176039
- Molecular Formula:
- C10H14N2O2
- Molecular Weight:
- 194.23
- MDL Number:
- MFCD02179232
- MOL File:
- 98400-69-2.mol
| Melting point | 145-149 °C |
|---|---|
| Boiling point | 252.7±13.0 °C(Predicted) |
| Density | 1.131±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 12?+-.0.70(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C10H14N2O2/c1-10(2,3)14-9(13)12-8-4-6-11-7-5-8/h4-7H,1-3H3,(H,11,12,13) |
| InChIKey | DRZYCRFOGWMEES-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NC1C=CN=CC=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H302-H317-H335 | |||||||||
| Precautionary statements | P280-P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280g-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-43 | |||||||||
| Safety Statements | 36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
4-(Boc-amino)pyridine price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B3331 | 4-(tert-Butoxycarbonylamino)pyridine >98.0%(GC)(T) | 98400-69-2 | 5g | $87 | 2025-07-31 | Buy |
| TCI Chemical | B3331 | 4-(tert-Butoxycarbonylamino)pyridine >98.0%(GC)(T) | 98400-69-2 | 25g | $323 | 2025-07-31 | Buy |
| TRC | B621190 | 4-(Boc-amino)pyridine | 98400-69-2 | 5g | $70 | 2021-12-16 | Buy |
| Matrix Scientific | 075637 | 4-(Boc-amino)pyridine 95+% | 98400-69-2 | 25g | $74 | 2021-12-16 | Buy |
| AK Scientific | J96437 | 4-(Boc-amino)pyridine | 98400-69-2 | 25g | $75 | 2021-12-16 | Buy |
4-(Boc-amino)pyridine Chemical Properties,Uses,Production
Chemical Properties
White to light brown solid
Uses
4-(Boc-amino)pyridine is a protected derivative of the amino acid Pyridine, a heterocyclic compound that is commonly found in biological specimens (such as human red blood cells), and is used as a starting reagent and intermediate in the chemical and pharmaceutical industries.
Synthesis
504-24-5
24424-99-5
98400-69-2
At room temperature, 4-aminopyridine (600 mg, 6.36 mmol), 4-dimethylaminopyridine (DMAP, 600 μg, 5.00 μmol), di-tert-butyl dicarbonate (Boc2O, 1.57 mL, 7.00 mmol) and triethylamine (Et3N, 1 mL, 7.63 mmol) were suspended in anhydrous tetrahydrofuran (THF, 3 mL) in anhydrous tetrahydrofuran (THF, 3 mL) and the reaction was stirred under argon protection for 20 min. After completion of the reaction, the reaction mixture was diluted with dichloromethane (CH2Cl2, 5 mL) and washed with 0.1 N hydrochloric acid (5 mL). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated by rotary evaporation. Finally, the target product 4-(tert-butoxycarbonylamino)pyridine (S1w, 1.30 g, yield >99%) was purified as a white solid by column chromatography (eluent ratio 30:1 dichloromethane/methanol).
References
[1] Tetrahedron Letters, 2006, vol. 47, # 7, p. 1087 - 1091
[2] Organic and Biomolecular Chemistry, 2006, vol. 4, # 14, p. 2769 - 2771
[3] Chemistry Letters, 2010, vol. 39, # 11, p. 1127 - 1129
[4] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 9, p. 2114 - 2124
[5] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8318 - 8322
4-(Boc-amino)pyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
View Lastest Price from 4-(Boc-amino)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-10-27 | 4-(Boc-amino)pyridine
98400-69-2
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-12-20 | 4-(Boc-amino)pyridine
98400-69-2
|
US $1.00 / g | 1g | 99% | g/kg/T | Career Henan Chemical Co |
-
- 4-(Boc-amino)pyridine
98400-69-2
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 4-(Boc-amino)pyridine
98400-69-2
- US $1.00 / g
- 99%
- Career Henan Chemical Co
