RU 28362
- CAS No.
- 74915-64-3
- Chemical Name:
- RU 28362
- Synonyms
- 11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one;11β,17β-Dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-trien-3-one;(11β,17β)-11,17-Dihydroxy-6-methyl-17-(1-propynyl)-androsta-1,4,6-trien-3-one;Androsta-1,4,6-trien-3-one, 11,17-dihydroxy-6-methyl-17-(1-propynyl)-, (11β,17β)-
- CBNumber:
- CB9504460
- Molecular Formula:
- C23H28O3
- Molecular Weight:
- 352.47
- MDL Number:
- MFCD03703410
- MOL File:
- 74915-64-3.mol
- MSDS File:
- SDS
| Boiling point | 533.2±50.0 °C(Predicted) |
|---|---|
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 33 mg/mL, soluble |
| form | solid |
| pka | 12.82±0.70(Predicted) |
| FDA UNII | VH397CN9SV |
RU 28362 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | SHG0004928 | (11BETA,17BETA)-11,17-DIHYDROXY-6-METHYL-17-(1-PROPYNYL)-ANDROSTA-1,4,6-TRIEN-3-ONE 95.00% | 74915-64-3 | 5MG | $497.12 | 2021-12-16 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| SHG0004928 | 5MG | $497.12 | Buy |
RU 28362 Chemical Properties,Uses,Production
Uses
RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion[1][2]. RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo
RU28362 (150 μg/kg; i.p.) inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion and selectively suppressed the stress-induced increase in POMC hnRNA in the anterior pituitary gland[2].
| Animal Model: | 250-350 g, adult male Sprague-Dawley rats[2] |
| Dosage: | 150 μg/kg |
| Administration: | I.p.; 60 min before exposure to a 15-min period of restraint stress |
| Result: | Inhibited adrenocorticotrophic hormone (ACTH) and corticosterone secretion and selectively suppressed the stress-induced increase in POMC hnRNA in the anterior pituitary gland. |
References
[1] Sandau US, et al. Glucocorticoids exacerbate hypoxia-induced expression of the pro-apoptotic gene Bnip3 in the developing cortex. Neuroscience. 2007 Jan 19;144(2):482-94. DOI:10.1016/j.neuroscience.2006.10.003
[2] Ginsberg AB, et al. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb;18(2):129-38. DOI:10.1111/j.1365-2826.2005.01396.x
RU 28362 Preparation Products And Raw materials
Raw materials
Preparation Products
RU 28362 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49709 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |
