RK-682
- CAS No.
- 154639-24-4
- Chemical Name:
- RK-682
- Synonyms
- RK-682;TAN 1364B;(Rac)-RK-682;ANTIBIOTIC RK-682;ANTIBIOTIC TAN 1364B;RK-682, STREPTOMYCES SPECIES;3-HEXADECANOYL-5-HYDROXYMETHYL-TETRONIC ACID;RK-682, protein tyrosine phosphatase (PTP) inhibitor;CI 010, 3-hexadecanoyl-5-hydroxyMethyltetronic acid.;2(5H)-Furanone, 4-hydroxy-5-(hydroxymethyl)-3-(1-oxohexadecyl)-
- CBNumber:
- CB9706972
- Molecular Formula:
- C21H36O5
- Molecular Weight:
- 368.51
- MDL Number:
- MFCD09752706
- MOL File:
- 154639-24-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
RK-682 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27964 | TAN 1364B ≥95% | 154639-24-4 | 500μg | $314 | 2026-04-30 | Buy |
| Cayman Chemical | 27964 | TAN 1364B ≥95% | 154639-24-4 | 2.5mg | $1098 | 2026-04-30 | Buy |
| Usbiological | A2297-30 | Antibiotic RK-682 (Antibiotic TAN 1364B, Antibiotic CI 010) >95%byHPLC | 154639-24-4 | 500ug | $482 | 2026-06-03 | Buy |
| ChemScene | CS-0255411 | (Rac)-RK-682 | 154639-24-4 | 500??g | $743 | 2026-06-04 | Buy |
| ChemScene | CS-0255411 | (Rac)-RK-682 | 154639-24-4 | 1mg | $1189 | 2026-06-04 | Buy |
RK-682 Chemical Properties,Uses,Production
Description
TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682 . TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC50s = 8.6, 12.4, and 0.7 μM, respectively), but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.
Uses
TAN 1364B (RK-682) is the most abundant analogue of a tetronic acid complex isolated from Streptomyces species, first patented by Takeda in 1993 and more formally identified by Ciba Geigy as the sodium salt of 3-hexadecanoyl-5-hydroxymethyltetronic acid. In 1995 researchers at RIKEN reported the isolation of 3-hexadecanoyl-5-hydroxymethyltetronic acid, named as RK-682. Subsequent synthesis in 2001 showed that the RIKEN RK-682 was in fact the calcium complex of TAN 1364B formed as an artefact during silica chromatography. As the complex, salt or free acid, TAN 1364B inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. However, it is unclear whether biological activity is due to the monomer (TAN 1364B) or dimeric complex (RK-682)
Uses
TAN 1364B is the most abundant analogue of a tetronic acid complex isolated from Streptomyces species, first patented by Takeda in 1993 and more formally identified by Ciba Geigy as the sodium salt of 3-hexadecanoyl-5-hydroxymethyltetronic acid. In 1995 researchers at RIKEN reported the isolation of 3-hexadecanoyl-5-hydroxymethyltetronic acid, named as RK-682. Subsequent synthesis in 2001 showed that the RIKEN RK-682 was in fact the calcium complex of TAN 1364B formed as an artefact during silica chromatography. As the complex, salt or free acid, TAN 1364B inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. However, it is unclear whether biological activity is due to the monomer (TAN 1364B) or dimeric complex (RK-682)
References
[1] VNIA M.T. CARNEIRO . Is RK-682 a promiscuous enzyme inhibitor Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues[J]. European Journal of Medicinal Chemistry, 2015, 97: Pages 42-54. DOI: 10.1016/j.ejmech.2015.04.036
RK-682 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301590 | njduly@126.com | China | 3293 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8857 | 58 |
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