3-Cyclohexylaminopropanesulfonic Acid
- CAS No.
- 1135-40-6
- Chemical Name:
- 3-Cyclohexylaminopropanesulfonic Acid
- Synonyms
- CAPS;3-(CYCLOHEXYLAMINO)-1-PROPANESULFONIC ACID;Seals;N-Cyclohexyl-3-aminopropanesulfonic acid;CAPS3;Push-on caps;CAPS, ULTROL;CAPS ULTRAPURE;CAPS, free acid;CAPS Buffer salt
- CBNumber:
- CB9732670
- Molecular Formula:
- C9H19NO3S
- Molecular Weight:
- 221.32
- MDL Number:
- MFCD00003837
- MOL File:
- 1135-40-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >300 °C(lit.) |
|---|---|
| Density | 1.1809 (rough estimate) |
| bulk density | 400kg/m3 |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5250 (estimate) |
| Flash point | >110℃ |
| storage temp. | room temp |
| solubility | H2O: 0.5 M at 20 °C, clear |
| form | Powder/Solid |
| color | White |
| Odor | Odorless |
| PH Range | 3 - 7 |
| PH | 3.0-7.0 (20℃, 0.5M in H2O) |
| pka | 10.4(at 25℃) |
| Water Solubility | 9 g/100 mL (20 ºC) |
| λmax |
λ: 260 nm Amax: ≤0.04 λ: 280 nm Amax: ≤0.04 |
| Merck | 14,1767 |
| BRN | 2835588 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | 1S/C9H19NO3S/c11-14(12,13)8-4-7-10-9-5-2-1-3-6-9/h9-10H,1-8H2,(H,11,12,13) |
| InChIKey | PJWWRFATQTVXHA-UHFFFAOYSA-N |
| SMILES | OS(=O)(=O)CCCNC1CCCCC1 |
| LogP | 0.3 at 25℃ |
| CAS DataBase Reference | 1135-40-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 4W981O1LXP |
| EPA Substance Registry System | 1-Propanesulfonic acid, 3-(cyclohexylamino)- (1135-40-6) |
| Absorption |
≤0.2 at 260 in H2O at 0.5M ≤0.2 at 280 in H2O at 0.5M |
| UNSPSC Code | 41121821 |
| NACRES | SB.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/38-36/37/38-22-20/21/22-40/22 | |||||||||
| Safety Statements | 26-36/37/39-37/39-24/25-22-23-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TZ6395000 | |||||||||
| F | 34 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29213099 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3-Cyclohexylaminopropanesulfonic Acid price More Price(98)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BR702885 | BRAND® combi-pack caps and seal for Transferpettor 1000-5000 μL, 2 PP caps, 1 PE seal | 1 set | $12.5 | 2025-07-31 | Buy | |
| Sigma-Aldrich | BR702885 | BRAND® combi-pack caps and seal for Transferpette® for Transferpettor 1000-5000 μL | 1135-40-6 | 1SET | $12.5 | 2023-01-07 | Buy |
| Sigma-Aldrich | 29337 | CAPS BioUltra, ≥99.0% (TLC) | 1135-40-6 | 25g | $70.6 | 2023-01-07 | Buy |
| Sigma-Aldrich | 29337 | CAPS BioUltra, ≥99.0% (TLC) | 1135-40-6 | 100g | $214 | 2023-01-07 | Buy |
| TCI Chemical | C0921 | 3-Cyclohexylaminopropanesulfonic Acid [Good's buffer component for biological research] >98.0%(T) | 1135-40-6 | 25g | $32 | 2026-04-30 | Buy |
3-Cyclohexylaminopropanesulfonic Acid Chemical Properties, Uses, Production
Chemical Properties
White/clear crystalline powder
Uses
3-Cyclohexylaminopropanesulfonic Acid buffer salt is used to formulate CAPS buffer, a zwitterionic buffer that is useful in the range of pH 7.9-11.1. CAPS buffer is widely used in Western and immunoblotting experiments as well as protein sequencing and identification. Used in the electrotransfer of proteins to PVDF (sc-3723) or nitrocellulose membranes (sc-3718, sc-3724). The high pH of this buffer makes it useful for the transfer of proteins with a pI > 8.5. CAPS is not one of the original Good's buffers, although it has a similar structure to the other propanesulfonic acids and was selected as a highly water soluble buffering reagent with an optimum buffering pH of 10.4 and minimal reactivity with enzymes or proteins, minimal salt effects. It is a biological buffer.
Description
3-Cyclohexylaminopropanesulfonic Acid, also known as 3-(Cyclohexylamino)-1-propanesulfonic acid (CHAPS) or N-Cyclohexyl-3-aminopropanesulfonic acid, is a detergent with a high affinity for basic proteins that can be used to extract these proteins from biological samples and solubilize them. CHAPS is a type of ampholyte, which means it has both anionic and cationic groups.
Definition
ChEBI: Cyclohexylaminopropanesulfonic acid is an amine.
Flammability and Explosibility
Not classified
References
[1] David A. Paulls, A. Townshend. “Sensitized determination of sulfite using flow injection with chemiluminescent detection.” Analyst 6 1 (1995): 467–469.
[2] Takashi Yoshitake. “Simultaneous determination of norepinephrine, serotonin, and 5-hydroxyindole-3-acetic acid in microdialysis samples from rat brain by microbore column liquid chromatography with fluorescence detection following derivatization with benzylamine.” Analytical biochemistry 312 2 (2003): 125–33.
[3] Keiichi Fujimori. “Determination of Sulfide with Acidic Permanganate Chemiluminescence for Development of Deep-sea in-situ Analyzers.” Analytical Sciences 27 2 (2011): 183–186.
3-Cyclohexylaminopropanesulfonic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei New Desheng Materials Technology Co., Ltd. | 0711-3702650 18971041571 | vickyzhao@whdschem.com | China | 57 | 58 |
| Nanjing Search Biotech Co., Ltd | +86-025-81682922 +86-13515111588 | sales@searchbio.com.cn | China | 137 | 68 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Hunan Waybel Advanced Materials Co.,Ltd | 400-0909710 13319523173 | ivy@hnhbsj.com | China | 456 | 60 |
| Hunan Hengfei bio-pharmaceutical Co. , Ltd. | 0746-6222194 13874779848 | 57182844@qq.com | China | 52 | 58 |
| Hubei jian chu biological technology co., LTD | 027-65528353 13554206703 | HBJC3279834739@foxmail.com | China | 1000 | 58 |
| Wuhan Jadechem Chemicals., Ltd. | 0724-0724-6055096 13545063953 | 44403767@qq.com | China | 29 | 58 |
| Shanghai CanSpecsci Instrument Co., Ltd. | 400-6087598 15021221957 | order@canspecsci.com | China | 2001 | 56 |
| Hubei Hechang New Material Technology Co., Ltd. | 13296505482 | yuki.peng@hechangchem.com | China | 30 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
Related articles
- Zwitterionic buffer-3-Cyclohexylaminopropanesulfonic Acid
- CAPS is one of zwitterionic buffers, which contains a cyclohexylamine group and a sulfonic acid group, and have some advantage....
- Jan 13,2025
View Latest Price from 3-Cyclohexylaminopropanesulfonic Acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | N-Cyclohexyl-3-aminopropanesulfonic acid
1135-40-6
|
1kg/bag | ≥98% | 50 T/Month | Hebei Qujie Technology Co., Ltd. | ||
 |
2026-09-17 | N-Cyclohexyl-3-aminopropanesulfonic acid
1135-40-6
|
$5.00 | 1kg | ≥99% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-09-17 | CAPS
1135-40-6
|
1KG | 99%min | 500kgs | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- N-Cyclohexyl-3-aminopropanesulfonic acid
1135-40-6
- $0.00
- ≥98%
- Hebei Qujie Technology Co., Ltd.
-
- N-Cyclohexyl-3-aminopropanesulfonic acid
1135-40-6
- $5.00
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- CAPS
1135-40-6
- $0.00
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
