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N-Cbz-L-serine methyl ester

N-Cbz-L-serine methyl ester structure

CAS No.: 1676-81-9

Chemical Name:: N-Cbz-L-serine methyl ester

Synonyms: methyl ((benzyloxy)carbonyl)-L-serinate;CBZ-SER-OME;Cbz-L-Ser-OMe;N-CARBOBENZOXY-L-SERINE METHYL ESTER;Z-SER-OME;Z-L-SER-OME;Z-SERINE-OME;Z-Ser-OMe (oil);Z-Ser-OMe (Syrup);Z-L-SERINE METHYL ESTER

CBNumber:: CB9754579

Molecular Formula:: C12H15NO5

Molecular Weight:: 253.25

MDL Number:: MFCD00077039

MOL File:: 1676-81-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 06:05:39

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N-Cbz-L-serine methyl ester Properties

Melting point	41-43 °C(lit.)
Boiling point	170 °C0.01 mm Hg(lit.)
Density	1.2499 (rough estimate)
refractive index	-15 ° (C=1, MeOH)
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform, Methanol
form	Viscous Liquid or Solid
pka	10.49±0.46(Predicted)
color	Pale yellow
optical activity	-13.4°(C=0.01 g/ml MEOH)
CAS DataBase Reference	1676-81-9(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Safety Statements

24/25

WGK Germany

HS Code

29242990

NFPA 704

	1
0		0

N-Cbz-L-serine methyl ester price More Price(78)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	469165	N-Z-L-serine methyl ester 95%	1676-81-9	10g	$170	2026-04-30	Buy
Sigma-Aldrich	469165	N-Z-L-serine methyl ester 95%	1676-81-9	1g	$34.5	2023-06-20	Buy
TCI Chemical	C1403	N-Carbobenzoxy-L-serine Methyl Ester >98.0%(N)	1676-81-9	5g	$81	2026-04-30	Buy
TCI Chemical	C1403	N-Carbobenzoxy-L-serine Methyl Ester >98.0%(N)	1676-81-9	25g	$271	2026-04-30	Buy
Usbiological	242837	Z-L-serine methyl ester 98+% (HPLC) ≥98%(HPLC)		1g	$163	2026-06-03	Buy

Product number	Packaging	Price	Buy
469165	10g	$170	Buy
469165	1g	$34.5	Buy
C1403	5g	$81	Buy
C1403	25g	$271	Buy
242837	1g	$163	Buy

N-Cbz-L-serine methyl ester Chemical Properties,Uses,Production

Chemical Properties

Clear Waxy Solid

Uses

N-Cbz-L-serine methyl ester is used to inhibit the activity of Mycobacterium tuberculosis in studies. Also used in the synthesis of pyrazinecarboxamide-based compounds acting as inhibitors of diacylglycerol acetyltransferases regarding treatment of obesity.

Uses

N-[(Phenylmethoxy)carbonyl]-L-serine Methyl Ester is used to inhibit the activity of Mycobacterium tuberculosis in studies. Also used in the synthesis of pyrazinecarboxamide-based compounds acting as inhibitors of diacylglycerol acetyltransferases regarding treatment of obesity.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

5680-80-8

501-53-1

1676-81-9

To a suspension of L-serine methyl ester hydrochloride (1.00 g, 6.43 mmol, 1.00 equiv) in dioxane (5.00 mL) was added an aqueous solution (25.7 mL) of NaHCO3 (1.62 g, 19.3 mmol, 3.00 equiv). Subsequently, a dioxane solution (15.0 mL, diluted with 4.20 mL dioxane) of benzyl chloroformate (Cbz-Cl, 1.10 mL, 7.72 mmol, 1.20 eq.) was added to the reaction system and the reaction was stirred at 25 °C. After 5 hours of reaction, the reaction was quenched with 1 M HCl aqueous solution and the aqueous layer was extracted with ethyl acetate (2×). The organic layers were combined, washed with 10% NaCl aqueous solution, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane solution of 50% ethyl acetate) to afford N-benzyloxycarbonyloxy-L-serine methyl ester (1.50 g, 5.92 mmol, 92% yield) as a colorless oil.

References

[1] Journal of Organic Chemistry, 1996, vol. 61, # 16, p. 5528 - 5531
[2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 26, p. 7177 - 7192
[3] Synthesis, 1996, # 2, p. 189 - 191
[4] Beilstein Journal of Organic Chemistry, 2017, vol. 13, p. 106 - 110
[5] Organic Letters, 2018, vol. 20, # 4, p. 1019 - 1022

N-Cbz-L-serine methyl ester Preparation Products And Raw materials

Raw materials

Methanol N-Cbz-L-Serine L-Serine methyl ester hydrochloride L-Serine methyl ester Benzyl chloroformate

Iodomethane Water Sodium bicarbonate 1,4-Dioxane

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Preparation Products

L-Serine methyl ester (S)-Benzyl 4-formyl-2,2-dimethyloxazolidine-3-carboxylate (S)-3-Benzyl 4-methyl 2,2-dimethyloxazolidine-3,4-dicarboxylate

N-Cbz-L-serine methyl ester Suppliers

Global( 227)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Adamas Reagent, Ltd.	59
Accela ChemBio Co.,Ltd.	64

View Lastest Price from N-Cbz-L-serine methyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-06	Cbz-L-Ser-Ome 1676-81-9	$1.00	1g	98%	100KG	Sichuan Jiaying Lai Technology Co.,LTD
	2019-07-06	N-Cbz-L-serine methyl ester 1676-81-9	$1.00	1KG	99%	20kg	Career Henan Chemical Co

Cbz-L-Ser-Ome
1676-81-9
$1.00
98%
Sichuan Jiaying Lai Technology Co.,LTD

N-Cbz-L-serine methyl ester
1676-81-9
$1.00
99%
Career Henan Chemical Co

N-Cbz-L-serine methyl ester Spectrum

N-Cbz-L-serine methyl ester(1676-81-9)¹HNMR

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N-CARBOBENZYLOXY-L-SERINE METHYL ESTER N-CBZ-L-SERINE METHYL ESTER CBZ-L-Serine methyleester L-Serine, N-[(phenylmethoxy)carbonyl]-, methyl ester Z-Ser-OMe (Syrup) (2S)-3-hydroxy-2-(phenylmethoxycarbonylamino)propanoic acid methyl ester (S)-3-Hydroxy-2-(benzyloxycarbonylamino)propionic acid methyl ester [(S)-3-Hydroxy-1-oxo-1-methoxypropan-2-yl]carbamic acid benzyl ester CBZ-L-SERINE METHYL ESTER N-Cbz-L-serine Methyl Ester Z-Ser-OMe N-[(Phenylmethoxy)carbonyl]-L-serine Methyl Ester N-Carbobenzoxy-L-serine Methyl Ester Methyl (2S)-2-{[(benzyloxy)carbonyl]-amino}-3-hydroxypropanoate Z-Ser-OMe (oil) (S)-Z-2-amino-3-hydroxypropionic acid methyl ester Z-L-serine methyl ester≥ 98% (HPLC) Z-L-β-hydroxyalanine methyl ester N-ALPHA-CARBOBENZOXY-L-SERINE METHYL ESTER n-z-l-serine methyl ester Z-SER-OME Z-SERINE-OME Z-L-SERINE METHYL ESTER N-Benzyloxycarbonyl-L-serine methyl ester Z-L-SER-OME (S)-METHYL 2-(BENZYLOXYCARBONYLAMINO)-3-HYDROXYPROPANOATE N-Carbobenzoxy-L-serine Methyl Ester > methyl (2S)-3-hydroxy-2-(phenylmethoxycarbonylamino)propanoate N-Cbz-L-serine Methyl Ester,97% N-Z-L-serine methyl ester N-Z-L-serine methyl ester, >98% CBZ-SER-OME Cbz-L-Ser-OMe methyl ((benzyloxy)carbonyl)-L-serinate N-CARBOBENZOXY-L-SERINE METHYL ESTER 1676-81-9 Cbz-Amino Acids Protected & Labeled Amino Acids Amino Acids (N-Protected) Amino Acid Derivatives Peptide Synthesis Specialty Synthesis Serine Amino Acids Amino Acids (N-Protected) Biochemistry Cbz-Amino Acids Amino Acid Derivatives Peptide Synthesis Serine