2-(1H-Imidazol-2-yl)-pyrazine
- CAS No.
- 119165-68-3
- Chemical Name:
- 2-(1H-Imidazol-2-yl)-pyrazine
- Synonyms
- 2-(1H-2-IMidazolyl)pyrazine;2-(1H-Imidazol-2-yl)-pyrazine;Pyrazine, 2-(1H-imidazol-2-yl)-
- CBNumber:
- CB9832785
- Molecular Formula:
- C7H6N4
- Molecular Weight:
- 146.15
- MDL Number:
- MFCD08668973
- MOL File:
- 119165-68-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
2-(1H-Imidazol-2-yl)-pyrazine price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 62612 | 2-(1H-2-IMIDAZOLYL)PYRAZINE 97% | 119165-68-3 | 0.25G | $24 | 2026-04-30 | Buy |
| AstaTech | 62612 | 2-(1H-2-IMIDAZOLYL)PYRAZINE 97% | 119165-68-3 | 1G | $97 | 2026-04-30 | Buy |
| Activate Scientific | AS46888 | 2-(1H-Imidazol-2-yl)pyrazine 98% | 119165-68-3 | 1g | $149 | 2026-06-04 | Buy |
| Activate Scientific | AS46888 | 2-(1H-Imidazol-2-yl)pyrazine 98% | 119165-68-3 | 5g | $712 | 2026-06-04 | Buy |
| Matrix Scientific | 131905 | 2-(1H-Imidazol-2-yl)pyrazine | 119165-68-3 | 250.00mg | $25 | 2026-05-18 | Buy |
2-(1H-Imidazol-2-yl)-pyrazine Chemical Properties, Uses, Production
Synthesis
19847-12-2
645-36-3
119165-68-3
Step 1: Synthesis of 2-(1H-imidazol-2-yl)pyrazine 2,2-Diethoxyethylamine (3 g, 2.25 mmol) was dissolved in anhydrous methanol (20 mL). To this solution was added sodium methanol (1.22 g, 22.5 mmol, as a 25% methanol solution). After stirring for 25 minutes at room temperature, pyrazine-2-carbonitrile (2.37 g, 22.5 mmol) and acetic acid (1.35 g, 22.5 mmol) were added sequentially, followed by stirring of the reaction mixture at 50 °C for 1 hour. Upon completion of the reaction, methanol (40 mL) and 6N hydrochloric acid (12 mL) were added and the reaction mixture was stirred overnight under reflux conditions. After cooling the reaction mixture to room temperature, the layers were separated by partitioning with 1:1 ether and water (60 mL). The aqueous layer was alkalized to pH 9-10 and extracted with a dichloromethane solution of 10% methanol. The organic extracts were combined, dried with magnesium sulfate, filtered and concentrated to afford the target compound 2-(1H-imidazol-2-yl)pyrazine (1.49 g, yellow solid). 1H NMR (400 MHz, MeOH-d4) δ ppm: 7.67 (s, 1H), 7.09 (d, J = 1.8 Hz, 1H), 6.99 (d, J = 2.5 Hz, 1H), 5.72 (s, 2H).
References
[1] Patent: WO2012/93148, 2012, A1. Location in patent: Page/Page column 36-37
[2] Patent: US2014/11802, 2014, A1. Location in patent: Paragraph 0196; 0197
2-(1H-Imidazol-2-yl)-pyrazine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
2-(1H-Imidazol-2-yl)-pyrazine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1998 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| SanoChem (Chengdu) Tech. Co., Ltd. | 28-87999436 02887999436 | sales@sano-chem.com | China | 3792 | 55 |
| Chengdu Research Accelerators Technology Co., Ltd. | 028-64353063 | reacchemical@163.com | China | 5243 | 58 |
| Jiaxing Rich Biological Technology Co., Ltd. | 0573-11111111-1111 18969316891 | richmol@163.com | China | 450 | 50 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Yujinpharma(Tianjin) Technology Co.,Ltd. | 13370351217 kungfu1217@1 | kungfu1217@163.com | China | 7991 | 58 |
