5-Bromo-1-chloroisoquinoline
- CAS No.
- 34551-41-2
- Chemical Name:
- 5-Bromo-1-chloroisoquinoline
- Synonyms
- 5-broMo-1-chloroisoquinolin;5-Bromo-1-chloroisoquinoline;1-Chloro-5-bromoisoquinoline;Isoquinoline, 5-bromo-1-chloro-;5-Bromo-1-chloro-2-azanaphthalene;5-Bromo-1-chloroisoquinoline (BIQ);5-BROMO-1-CHLOROISOQUINOLINE ISO 9001：2015 REACH
- CBNumber:
- CB9842591
- Molecular Formula:
- C9H5BrClN
- Molecular Weight:
- 242.5
- MDL Number:
- MFCD08703278
- MOL File:
- 34551-41-2.mol
- MSDS File:
- SDS
| Boiling point | 349.5±22.0 °C(Predicted) |
|---|---|
| Density | 1.673 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 1.06±0.43(Predicted) |
| form | powder |
| color | Grey brown |
| InChI | InChI=1S/C9H5BrClN/c10-8-3-1-2-7-6(8)4-5-12-9(7)11/h1-5H |
| InChIKey | XUWFLTLTPVIRCV-UHFFFAOYSA-N |
| SMILES | C1(Cl)C2=C(C(Br)=CC=C2)C=CN=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2933499090 |
5-Bromo-1-chloroisoquinoline price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FB42159 | 5-Bromo-1-chloroisoquinoline | 34551-41-2 | 50g | $2210.5 | 2026-06-04 | Buy |
| Biosynth | FB42159 | 5-Bromo-1-chloroisoquinoline | 34551-41-2 | 100g | $3075 | 2026-06-04 | Buy |
| Biosynth | FB42159 | 5-Bromo-1-chloroisoquinoline | 34551-41-2 | 250g | $5770 | 2026-06-04 | Buy |
| Activate Scientific | AS34375 | 5-Bromo-1-chloroisoquinoline 97% | 34551-41-2 | 1g | $64 | 2026-06-04 | Buy |
| Activate Scientific | AS34375 | 5-Bromo-1-chloroisoquinoline 97% | 34551-41-2 | 5g | $164 | 2026-06-04 | Buy |
5-Bromo-1-chloroisoquinoline Chemical Properties, Uses, Production
Uses
5-Bromo-1-chloroisoquinoline can be used as an organic synthesis intermediate, and there are literature reports that it can be used to prepare 5-benzylisoquinoline derivatives for the treatment of cardiovascular diseases.
Synthesis
34784-04-8
34551-41-2
General procedure for the synthesis of 5-bromo-1-chloroisoquinoline from 5-bromoisoquinoline: To a solution of 5-bromoisoquinoline (60 g, 288 mmol) in dichloromethane (1.5 L) was added 75% m-chloroperoxybenzoic acid (m-CPBA, 75 g, 436 mmol). The reaction mixture was heated and stirred at 40°C for 20 hours. Upon completion of the reaction, the progress of the reaction was confirmed by HPLC monitoring, and after the reaction mixture was cooled to room temperature, sodium thiosulfate (75 g) was added within 10 min, followed by water (300 mL). The organic phase was separated, washed with 1N sodium hydroxide solution and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give a white solid (42 g), which could be used directly in the next step of the reaction. The intermediate (37 g, 165 mmol) obtained above was dissolved in dichloromethane (900 mL), trichlorophosphorus (POCl3, 37 mL) was added, and the reaction was stirred for 18 hours at 45 °C. Upon completion of the reaction, the progress of the reaction was confirmed by HPLC and/or GC monitoring and the reaction mixture was concentrated under reduced pressure. The residue was carefully treated with water and the aqueous phase was extracted with dichloromethane. The organic phases were combined and washed sequentially with saturated sodium bicarbonate solution and saturated sodium chloride solution. Evaporation of the solvent under reduced pressure afforded the beige solid intermediate 5-bromo-1-chloroisoquinoline (33 g), which can be used directly in the next step of the reaction. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and GC-EI (70eV): 1H NMR δ 8.35 (2d, 2H), 8.00 (2d, 2H), 7.55 (t, 1H); GC-EI (70eV): M+. = 241.
References
[1] Patent: US2013/296320, 2013, A1
[2] Patent: WO2016/201052, 2016, A1
[3] Patent: US2017/137385, 2017, A1. Location in patent: Paragraph 0203; 0204; 0205; 0206
5-Bromo-1-chloroisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Na Qian Chemical Technology Co. Ltd. | 13598610367 13598610367 | 2841375912@qq.com | China | 3703 | 52 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 988 | 62 |
| Puyang Anruida New Materials Research and Development Co., Ltd. | 18367380348 13305832579 | sales@jxartech.com | China | 63 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Adamas Reagent, Ltd. | 4006009262 13023226327 | hmj@titansci.com | China | 14098 | 59 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1205 | 64 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1406 | 59 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Record Tech (Shanghai) Co., LTD | 13761627472 | 183009664@qq.com | China | 659 | 62 |
View Latest Price from 5-Bromo-1-chloroisoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-BROMO-1-CHLOROISOQUINOLINE
34551-41-2
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2025-04-04 | 5-Bromo-1-chloroisoquinoline
34551-41-2
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2020-01-13 | 5-BROMO-1-CHLOROISOQUINOLINE
34551-41-2
|
$1.00 | 1g | 99% | 10000KGS | Career Henan Chemical Co |
-
- 5-BROMO-1-CHLOROISOQUINOLINE
34551-41-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Bromo-1-chloroisoquinoline
34551-41-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5-BROMO-1-CHLOROISOQUINOLINE
34551-41-2
- $1.00
- 99%
- Career Henan Chemical Co
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