4-(Dimethylamino)phenylboronic acid
- CAS No.
- 28611-39-4
- Chemical Name:
- 4-(Dimethylamino)phenylboronic acid
- Synonyms
- 4-(N,N-DIMETHYLAMINO)PHENYLBORONIC ACID;AKOS BRN-0094;RARECHEM AH PB 0156;4-dimethylaminobenzene borate;4-N,N-Dimethylphenylboronic acid;4-(N,N-DiMethylaMino)phenylbor. ac;4-DIMENTHYLAMINOPHENYLBORONIC ACID;4-(dimethylamino)phenyl]boronicaci;[4-(Dimethylamino)phenyl]boric acid;4-(DIMETHYLAMINO)PHENYLBORONIC ACID
- CBNumber:
- CB9853430
- Molecular Formula:
- C8H12BNO2
- Molecular Weight:
- 165
- MDL Number:
- MFCD01074642
- MOL File:
- 28611-39-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 227 °C(lit.) |
|---|---|
| Boiling point | 329.9±44.0 °C(Predicted) |
| Density | 1.12±0.1 g/cm3(Predicted) |
| storage temp. | 0-6°C |
| pka | 8.78±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to green-gray or blue-gray |
| Water Solubility | Sparingly soluble in water. (~2.5%) |
| InChI | InChI=1S/C8H12BNO2/c1-10(2)8-5-3-7(4-6-8)9(11)12/h3-6,11-12H,1-2H3 |
| InChIKey | RIIPFHVHLXPMHQ-UHFFFAOYSA-N |
| SMILES | B(C1=CC=C(N(C)C)C=C1)(O)O |
| CAS DataBase Reference | 28611-39-4(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P304+P340-P405-P501a-P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, AIR SENSITIVE, KEEP COLD | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-(Dimethylamino)phenylboronic acid price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4428 | 4-(Dimethylamino)phenylboronic Acid (contains varying amounts of Anhydride) | 28611-39-4 | 1g | $103 | 2026-04-30 | Buy |
| TCI Chemical | D4428 | 4-(Dimethylamino)phenylboronic Acid (contains varying amounts of Anhydride) | 28611-39-4 | 5g | $310 | 2026-04-30 | Buy |
| Biosynth | FD157710 | 4-(Dimethylamino)phenylboronic acid | 28611-39-4 | 25g | $900 | 2026-06-04 | Buy |
| Biosynth | FD157710 | 4-(Dimethylamino)phenylboronic acid | 28611-39-4 | 10g | $900 | 2026-06-04 | Buy |
| Apolloscientific | OR7205 | 4-(Dimethylamino)benzeneboronic acid 97% | 28611-39-4 | 1g | $69 | 2026-06-04 | Buy |
4-(Dimethylamino)phenylboronic acid Chemical Properties,Uses,Production
Chemical Properties
white to green-grey or blue-grey crystalline
Uses
suzuki reaction
Uses
4-(Dimethylamino)phenylboronic Acid can be used as reactant/reagent in preparation of biaryls via palladium-catalyzed Suzuki-Miyaura coupling of nitroarenes with boronic acids.
Synthesis
121-43-7
586-77-6
28611-39-4
Under argon protection, 20 g (100 mmol) of 4-bromo-N,N-dimethylaniline was dissolved in 400 mL of anhydrous tetrahydrofuran and the mixture was cooled to -40°C. The reaction was carried out with the aid of a liquid solution of 1.6 M n-butyllithium in hexane. Subsequently, 63 mL (100 mmol) of a hexane solution of 1.6 M n-butyllithium was slowly added dropwise, stirring was maintained and the reaction mixture was gradually warmed to 0 °C for 1 hour. The reaction mixture was again cooled to -78 °C and 50 mL of anhydrous tetrahydrofuran was added. A solution containing 26 g (250 mmol) of trimethyl borate was added dropwise, followed by raising the reaction mixture to room temperature and stirring for 5 hours. After completion of the reaction, 200 mL of 1 N hydrochloric acid solution was added and stirred for 1 h. The aqueous layer was separated and discarded. The organic layer was dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. The resulting solid was washed with toluene to afford 12.38 g (75 mmol) of the target product 4-(N,N-dimethylamino)phenylboronic acid in 75% yield.
References
[1] Patent: CN108276337, 2018, A. Location in patent: Paragraph 0057; 0058; 0059
4-(Dimethylamino)phenylboronic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhuhai Aobokai Biomedical Technology Co., Ltd. | 400-0628126 | sales-team@aobchem.com.cn | China | 49997 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Lastest Price from 4-(Dimethylamino)phenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-(Dimethylamino)phenylboronic acid
28611-39-4
|
$1.00 | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- 4-(Dimethylamino)phenylboronic acid
28611-39-4
- $1.00
- 99%
- Career Henan Chemical Co
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