4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl!morpholine
- CAS No.
- 568577-88-8
- Chemical Name:
- 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl!morpholine
- Synonyms
- 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]MORPHOLINE;4-(MORPHOLINO)PHENYLBORONIC ACID PINACOLATE;4-MORPHOLINOPHENYLBORONIC ACID, PINACOL ESTER;4-(4-Morpholinyl)benzeneboronic acid pinacol ester;4-Morpholin-4-ylbenzeneboronic acid pinacol ester ;4-(4-Morpholinyl)benzeneboronic acid pinacol ester, 95%;4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine;4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]mor...;4-[4-(4,4,5,5-Tetramethyl-1,2,3-dioxaborolan-2-yl)phenyl]morpholine;Morpholine, 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-
- CBNumber:
- CB8501619
- Molecular Formula:
- C16H24BNO3
- Molecular Weight:
- 289.18
- MDL Number:
- MFCD04112544
- MOL File:
- 568577-88-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 98.6-99.0℃ |
|---|---|
| Boiling point | 422.8±40.0 °C(Predicted) |
| Density | 1.09±0.1 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Storage temp. 2-8°C |
| pka | 4.65±0.40(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| InChI | 1S/C16H24BNO3/c1-15(2)16(3,4)21-17(20-15)13-5-7-14(8-6-13)18-9-11-19-12-10-18/h5-8H,9-12H2,1-4H3 |
| InChIKey | UCPALIMHMYIZPZ-UHFFFAOYSA-N |
| SMILES | B3(OC(C(O3)(C)C)(C)C)c1ccc(cc1)N2CCOCC2 |
| CAS DataBase Reference | 568577-88-8(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2934999090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl!morpholine price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS005194 | 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine AldrichCPR | 568577-88-8 | 100MG | $77.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | BML00054 | 4-Morpholinophenylboronic acid, pinacol ester Aldrich | 568577-88-8 | 1g | $114 | 2026-04-30 | Buy |
| TCI Chemical | T3705 | 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine >98.0%(GC) | 568577-88-8 | 1g | $124 | 2026-04-30 | Buy |
| TCI Chemical | T3705 | 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine >98.0%(GC) | 568577-88-8 | 5g | $489 | 2025-07-31 | Buy |
| Apolloscientific | OR2972 | 4-(Morpholin-4-yl)benzeneboronic acid, pinacol ester ≥95% | 568577-88-8 | 250mg | $21 | 2026-06-04 | Buy |
4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl!morpholine Chemical Properties,Uses,Production
Uses
4-(4-Morpholinyl)benzeneboronic acid pinacol ester is used as pharmaceutical intermediate.
Synthesis
30483-75-1
25015-63-8
568577-88-8
General procedure for the synthesis of 4-(4-morpholinyl)phenylboronic acid pinacol ester from 4-(4-bromophenyl)morpholine and pinacolborane: To a solution of 4-(4-bromophenyl)morpholine (20 g, 82.64 mmol) in dioxane (200 ml) were added pinacolborane (13.2 g, 99.17 mmol), dichlorobis(triphenylphosphine)palladium(II) (3 g 4.13 mmol) and triethylamine (34.5 ml, 247.93 mmol). The reaction mixture was heated under reflux conditions for 4 hours. After completion of the reaction, the mixture was poured into water. After extraction with dichloromethane, the organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane) to afford 4-(4-morpholinyl)benzeneboronic acid pinacol ester as an orange oil, which crystallized after cooling (19.98 g, 83.94% yield); APCI-MS m/z 289.07 ([M+H]+).
References
[1] Patent: WO2004/13135, 2004, A1. Location in patent: Page 48-49
[2] Patent: WO2004/16606, 2004, A1. Location in patent: Page 25
[3] Patent: WO2004/13138, 2004, A2. Location in patent: Page 23; 24
4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl!morpholine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| skychemical Co.Ltd | 021-20958197 20965099 | sales@skychemical.com | China | 1182 | 57 |
| QINGDAO CARELONGPHARMATECH CO.,LTD | 053288191853 13061484198 | sales@carelongchem.com | China | 455 | 57 |
View Lastest Price from 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl!morpholine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-03 | 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINE
568577-88-8
|
$7.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 4-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL!MORPHOLINE
568577-88-8
- $7.00
- 99%
- Career Henan Chemical Co
