Ciclesonide
- CAS No.
- 141845-82-1
- Chemical Name:
- Ciclesonide
- Synonyms
- Omnaris;Alvesco;AC1MIWNR;Rpr 251526;Ciclesonide;Unii-S59502J185;Ciclesonide USP/EP/BP;Pregna-1,4-diene-3,20-dione, 16,17-((cyclohexylmethylene)bis(oxy))-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11beta,16alpha(R))-;Pregna-1,4-diene-3,20-dione, 16,17-(((R)-cyclohexylmethylene)bis(oxy))-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11beta,16alpha)-;(R)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde, 21-isobutyrate
- CBNumber:
- CB9946932
- Molecular Formula:
- C32H45O7
- Molecular Weight:
- 540.69
- MDL Number:
- MOL File:
- Mol file
| FDA UNII | S59502J185 |
|---|
Ciclesonide Chemical Properties, Uses, Production
Asthma medication
Ciclesonide is a new inhaled glucocorticoid drug for treating asthma,it belongs to adrenocorticotropic hormone drugs, similar drugs also include beclomethasone dipropionate, budesonide, fluticasone propionate, the product is administrated in a non-active form ,it can be activated by endogenous esterases in the airway on the spot , it becomes into an active ingredient when it reaches the target organ-the lung; once it is activated, it shows a high topical anti-inflammatory activity.
Ciclesonide is successfully developed by the pharmaceutical company Altana, it was listed in January 2005 for the first time in the UK, it is currently available in Germany, Ireland, it is used for the treatment of adults with all levels of persistent severe asthma, one administration per day , a dose of 160μg or 80μg. For patients with severe asthma attack facing the risk of asthma, if the condition can not be controlled and strong anti-inflammatory drugs are required , the dose of this product be increased to 160μg.
In clinical trail phase III of severe patients with persistent asthma, ciclesonide has new release and distribution properties,it can reduce the local and systemic adverse reactions, and it can maintain high anti-asthma activity, it can significantly low the need on oral corticosteroids (OCS) in patients to maintain or improve effects of asthma control. Accordingly, it is an appropriate OCS saving therapy.
Side Effects
Ciclesonide becomes effective faster than budesonide,its systemic side effects are lower than the fluticasone propionate and budesonide, even though the highest doses of 160μg is used, plasma glucocorticoid inhibition is also higher than other corticosteroids inhalants (if high plasma corticosterone hormone levels are high ,the systemic side effects is high).
Local side effects comparison table is as follows:
Side effects of this product fluticasone propionate budesonide
Dysphonia (hoarseness) 1.6% 4% 1%-8%-6%
Sore throat 1.9% 10%-14% 5%-10%
Thrush 0.2%-5% 2% 2%-4%
The above information is edited by the chemicalbook of Tian Ye.
Uses
Treatment of asthma as prophylactic therapy in adults and adolescents.
Definition
ChEBI: Ciclesonide is an organic molecular entity.
brand name
Alvesco (Dynamit Nobel GmbH).
Ciclesonide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Wellman Pharmaceutical Co., Ltd. | -- | welman@welman.com | China | 7 | 60 |
| Yunnan Convek biochemistry Co., Ltd. | 18687219753 18687219753 | 3836098249@qq.com | China | 62 | 58 |
| Changsha Qisheng Heyan Medical Technology Co., LTD | 18684929597 | 527907673@qq.com | China | 127 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9739 | 58 | |
| Wuhan Biocar Bio-Pharm Co., Ltd. | 86 15387057351 | sales@biocar.cn | China | 113 | 55 |
| Nanjing Klender Bio-Technology Co., Ltd. | 025-52343882 18112933882 | sales@kldbio.com | China | 2019 | 55 |
| Heze Development Zone chuangli Chemical Co., Ltd. | 0530-+86-530-529 6766，+86-15666160102 15666160102 | info@chuangli-chem.com | China | 849 | 55 |
| Nanjing crow LuNing pharmaceutical technology co., LTD | 13382066392 | CHINA | 4851 | 58 | |
| Macheng jinxin biotechnology co., LTD | 18271582018 | 1126319697@qq.com | China | 1525 | 58 |
View Latest Price from Ciclesonide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | Ciclesonide | $150.00 | 1KG | 99% | 1000KG | Career Henan Chemical Co |
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- Ciclesonide
- $150.00
- 99%
- Career Henan Chemical Co
