アミノアセトアルデヒドジメチルアセタール 化学特性,用途語,生産方法
外観
無色～わずかにうすい黄色, 澄明の液体
溶解性
水に易溶。
用途
試験研究用、医薬中間体。
説明
Aminoacetaldehyde dimethyl acetal, also known as 2,2-dimethoxy-ethylamine, is a critical intermediate in the synthesis of ivabradine hydrochloride, proline analogs, praziquantel, and other raw materials. The existing process for producing aminoacetal dimethyl acetate uses vinyl acetate as the starting material, and the target product is synthesized through bromination, Gabriel synthesis, and hydrazinolysis.
化学的特性
clear colorless to pale yellow liquid
使用
Amino acetaldehyde dimethyl was used in preparation of chitosan- dendrimer hybrids having various functional groups such as carboxyl, ester and poly(ethylene glycol). It was used in an synthesis of a bicyclic proline analog from L-ascorbic acid and in 3-component reaction catalyzed by MgClO4 leading to α-aminophosphonates.
一般的な説明
Aminoacetaldehyde dimethyl acetal reacts with sulfone, followed by hydrolysis and reductive amination by adding desired piperazine derivative to yield piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine.
合成
1)
to disposable in container, add the ammonia soln that
monochloroacetaldehyde dimethyl acetal and concentration are 10～40%,
stir;
2) by step 1) in reaction solution stir, this reaction solution is warming up to 100～150 ℃;
3) by step 2) in reaction solution distill, reclaim ammoniacal liquor, until steam without obvious cut;
4) in step 3) in reaction solution in to add concentration be 20%～50% aqueous sodium hydroxide solution, regulate pH to 12～14;
5)
by step 4) in solution carry out rectifying, collect colourless and
light yellow transparent liquid, be target product aminoacetaldehyde
dimethyl acetal.
純化方法
Dry the acetal over KOH pellets and distil it through a 30cm vacuum jacketed Vigreux column (p 11). [Lawson J Am Chem Soc 75 3398 1953, Erickson et al. J Am Chem Soc 77 6640 1955, Beilstein 4 IV 1918.]
アミノアセトアルデヒドジメチルアセタール 上流と下流の製品情報
原材料
準備製品