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Ciprofloxacin hydrochloride C화학적 특성, 용도, 생산
용도
Anti-bacterial
상표명
Ciloxan (Alcon); Cipro (Bayer); Proquin (Esprit).
Synthesis
The preparation method of ciprofloxacin HCl, its step is as follows: a) cyclopropyl carboxylic acid is added in the organic solvent, and the adding piperazine, reacted 3～8 hours down as acid binding agent with alkali at 60～120 ℃, the monitoring cyclopropyl carboxylic acid is residual less than 2% o'clock termination reaction, stirring is cooled to 0～30 ℃, leaves standstill suction filtration; b) add water and hydrochloric acid in the products therefrom toward a) step, under agitation be warming up to molten clearly, add activated carbon decolorizing, filtered while hot, and transfer filtrate pH to 2～4 with hydrochloric acid, and the cooling crystallization filters, rinsing, and drying makes ciprofloxacin HCl.
