PF-03814735
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PF-03814735 속성
- 녹는점
- 181-183°C
- 밀도
- 1.443
- 저장 조건
- -20°C
- 용해도
- DMSO: 용해성20mg/mL, 투명
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 15.02±0.46(Predicted)
- 색상
- 흰색에서 베이지색
- InChIKey
- RYYNGWLOYLRZLK-RBUKOAKNSA-N
- SMILES
- FC(F)(F)c1c(nc(nc1)Nc3cc4c(cc3)[C@H]5N([C@@H]4CC5)C(=O)CNC(=O)C)NC2CCC2
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| WGK 독일 | 3 | ||
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| 스토리지 클래스 | 11 - Combustible Solids |
| 그림문자(GHS): |
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| 신호 어: | Warning | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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PF-03814735 C화학적 특성, 용도, 생산
개요
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. PF-화학적 성질
Off-White Solid용도
The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. PF-03814735 is a reversible inhibitor of both Aurora A and B kinases with IC50 values of 0.8 and 5 nM, respectively, in in vitro activity assays. PF-03814735 also inhibits the kinases FLT1, FAK, TrkA, Met, and FGFR1 with IC50 values of 10, 22, 30, 100, and 100 nM, respectively. PF-03814735 inhibits cell proliferation of HCT-116, HL-60, A549, and H125 tumor cell lines with IC50 values ranging from 42-150 nM and shows in vivo efficacy in an HCT-116 tumor xenograft mouse model. PF-03814735 has been shown to be particularly sensitive towards inhibiting the growth of small cell lung cancer cell lines and other tumors driven by the Myc family genes.[Cayman Chemical]PF-03814735 준비 용품 및 원자재
원자재
준비 용품
PF-03814735 공급 업체
글로벌( 141)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 |
sales@BioChemBest.com | China | 5996 | 61 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 |
shchemsky@sina.com | China | 32273 | 50 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 |
sales@trio-pharmatech.com | China | 1856 | 62 |
| BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 9920 | 65 |
| Shanghai civi chemical technology co.,Ltd | 86-21-34053660 |
sale@labgogo.com | China | 9853 | 52 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
China | 1490 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 |
info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 |
sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 |
info@adooq.com | United States | 2774 | 58 |