Mometasone furoate
|
|
Mometasone furoate 속성
- 녹는점
- 218-220°C
- 알파
- D26 +58.3° (dioxane)
- 끓는 점
- 655.5±55.0 °C(Predicted)
- 밀도
- 1.37±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: ≥20mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 13.02±0.70(Predicted)
- 색상
- 흰색에서 황백색까지
- 광학 활성
- [α]/D +50 to +60°, c = 0.5 in methanol
- InChIKey
- WOFMFGQZHJDGCX-ZULDAHANSA-N
- SMILES
- C[C@]12C[C@H](OC(=O)C3=CC=CO3)C3([C@](CCC4[C@]3(C)C=CC(=O)C=4)([H])[C@]1([H])C[C@@H](C)[C@]2(OC(=O)C1OC=CC=1)C(=O)CCl)Cl |&1:1,3,13,17,25,28,30,r|
- CAS 데이터베이스
- 83919-23-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| WGK 독일 | 3 | ||
|---|---|---|---|
| HS 번호 | 29372290 | ||
| 스토리지 클래스 | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
||
| Hazard Classifications | Repr. 1B |
Mometasone furoate MSDS
9-Chloro-17-(2-chloroacetyl)-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one furoate
Mometasone furoate C화학적 특성, 용도, 생산
개요
Mometasone furoate is a topical steroidal antiinflammatory useful in the treatment of corticosteroid-responsive dermatoses. As a steroidal antiinflammatory of grade II potency, mometasone furoate is characterized by a once-daily dose regimen and a relatively wide safety margin.화학적 성질
White-to-Off-White Solid용도
Mometasone furoate is a deuterated topical corticosteroid used as an anti-inflammatory. Mometasone furoate has been used to study its effect on Leishmania major amastigotes. It could as labeled Mometasone, intended for use as an internal standard for the quantification of Mometasone by GC- or LC-mass spectrometry. Formulations containing mometasone furoate have been used in the treatment of allergic rhinitis, atopic dermatitis, and asthma. Intranasal administration of mometasone furoate (1 μg/nostril) reduces the frequency of sneezing and nasal rubbing in a rat model of histamine-induced allergic rhinitis. Topical application of mometasone furoate reduces croton oil-induced ear edema in mice (ED50 = 0.31 μg/ml).Biological Functions
Mometasone furoate has strong local anti-inflammatory activity equivalent to that of fluticasone propionate. It has a quick onset of action relative to the other inhaled/intranasal steroids with the least systemic availability and, consequently, the fewest systemic side effects.일반 설명
Mometasone furoate (Asmanex,Nasonex) undergoes extensive metabolism to multiplemetabolites. No major metabolites are detectable in humanplasma after oral administration, but the 6β-hydroxy metaboliteis detectable by use of human liver microsomes. Thismetabolite is formed via the CYP3A4 pathway.Mechanism of action
Mometasone furoate is the most recent glucocorticoid to be developed and commercialized. It has a number of unique functional groups that confer enhanced glucocorticoid activity as well as pharmacokinetic advantages. The combination of the C-21 chloro and the furoic acid ester at C-17 results in the highest glucocorticoid receptor affinity of any topical corticosteroid. The 16α- methyl decreases the mineralocorticoid effects, and the 9α-chloro group increases both glucocorticoid and mineralocorticoid activities. Inhaled mometasone furoate acts locally as an anti-inflammatory treatment for asthma and has the least systemic bioavailability of all the inhaled glucocorticoids (<1%).Clinical Use
Mometasone furoate was originally marketed as a topically applied corticosteroid, but because of its low systemic bioavailability, it was found to be more useful in the treatment of allergic disorders and lung diseases (107).신진 대사
It is extensively metabolized, with 6β-hydroxymometasone and 21-hydroxymometasone being found among the metabolites. Inhaled mometasone furoate in mainly excreted in the feces (~74%) as metabolites and only minimally excreted in the urine (~8%). It has a relatively long half-life in the lung and is administered once daily, usually in the evening.Mometasone furoate 준비 용품 및 원자재
원자재
2-Furoyl chloride
염화 리튬
4-다이메틸아미노피리딘
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
메탄설포닐 클로라이드
2,3-디클로로-5,6-디시아노-1,4-벤조퀴논
모메타손푸로에이트불순물D
염산
아세트산(빙초산)
준비 용품
Mometasone furoate 공급 업체
글로벌( 671)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Zibo Shiji Zhonglian Medical Technology Co., Ltd. | 15069388126 |
sales@sjzlpharm.com | China | 65 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21533 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29766 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | 0531-68652808 18953170293 |
sales@sdzschem.com | China | 2921 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 |
sales@amoychem.com | China | 6339 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19935 | 58 |
| CONIER CHEM AND PHARMA LIMITED | |
sales@conier.com | China | 49906 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 |
marketing@targetmol.com | United States | 32431 | 58 |
| Hefei Hangang Pharmaceutical Technology Co., Ltd. | +8618062405514 |
ada@ipurechemical.com | China | 10224 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 |
laboratory@coreychem.com | China | 30203 | 58 |
Mometasone furoate 관련 검색:
프로필아민 모메타손푸로에이트IMpurityF (S)-(-)-테트라히드로-2-푸로산 1-아세톡시-3-클로로아세톤 2-클로로시클로헥사놀 클로로디플루오르메탄 2-푸란카르복실산이소아밀에스테르 에타논,2-클로로-1-사이클로펜틸-(9CI) 푸란-2-카르복실산 이소부틸2-푸로에이트 2-FUROIC-D3산 이소프로필2-푸로에이트 푸르푸랄-3,4,5-D3 부틸2-푸로에이트 트랜스-2-클로로사이클로헥산올
(16α)-21-Chloro-17-[(2-furanylcarbonyl)oxy]-16-Methyl-pregna-1,4-diene-3,11,20-trione
Sucrose Fatty Acid Ester
Aluminate coupling agent