LD50 orally in mice: 1000-2000 mg/kg (Imhof, Kyburz, 1986)
N-(2-아미노에틸)-5-클로르-2-피리딘카르복사미드-염산염 C화학적 특성, 용도, 생산
용도
Treatment of Alzheimer’s disease.
상표명
Tempium (Hoffmann-LaRoche).
생물학적 활성
Selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC 50 values are 0.03 and > 100 μ M for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC 50 values are 86, 123 and > 500 μ M for noradrenalin, serotonin and dopamine uptake respectively).