4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘
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4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 속성
- 녹는점
- 145.0 to 149.0 °C
- 끓는 점
- 505.3±60.0 °C(Predicted)
- 밀도
- 1.49
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 클로로포름 (약간 용해됨), DMSO (약간 용해됨)
- 물리적 상태
- powder to crystal
- 산도 계수 (pKa)
- 1.73±0.30(Predicted)
- 색상
- White to Orange to Green
- InChI
- InChI=1S/C13H10ClN3O2S/c1-9-2-4-10(5-3-9)20(18,19)17-7-6-11-12(14)15-8-16-13(11)17/h2-8H,1H3
- InChIKey
- BTOJSYRZQZOMOK-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C2C=CN(S(C3=CC=C(C)C=C3)(=O)=O)C2=N1
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
그림문자(GHS): |
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유해·위험 문구: |
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예방조치문구: |
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4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 C화학적 특성, 용도, 생산
용도
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.Synthesis
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (2kg, 12.96mol) and dichloromethane (40L) were added to the reaction flask at room temperature, stirred and dissolved. Triethylamine (3.88 kg, 38.4 mol) and 4-dimethylamino pyridine (157.6 g, 1.28 mol) were added in that order, and after stirring and dissolved, p-toluenesulfonyl chloride (2.6 kg, 13.6 mol) was added dropwise at 0 °C. The chloromethane (30 L) solution was added dropwise, and the mixture was stirred at room temperature for 30 min. After the TLC was applied, the mixture was washed with water (16L×3). 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (3.9 kg, yield 97.7%) was obtained after drying under reduced pressure.![4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine](/NewsImg/2024-04-11/6384842224037577876641123.png)
4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 준비 용품 및 원자재
원자재
테트라하이드로푸란
수소화나트륨
파라-톨루엔설폰일 염화물
2,4-DICHLORO-7H-피롤로2,3-DPYRIMIDINE
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
준비 용품
4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 공급 업체
글로벌( 415)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Minbiotech Co., Ltd. | +8617315815539 |
sales@minbiotech.com | CHINA | 129 | 58 |
Huanfu Industrial Co.,(Shanghai)Ltd. | +86-18001856580 |
2415195517@qq.com | China | 43 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20185 | 58 |
Capot Chemical Co.,Ltd. | +8613336195806 |
sales@capot.com | China | 29734 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 |
info@dakenam.com | China | 13090 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
Hi-Tech Chemistry Corp | 0519-86626038 |
yuhh@hitechem.com | CHINA | 810 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21620 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 관련 검색:
CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINEBIS-(염화물) 트리플루오로티민 2,4-DICHLORO-7H-피롤로2,3-DPYRIMIDINE 2-티오우라실 벤질에틸에테르 4-(하이드록시아미노)-4-옥소부탄산 1-벤질-N,4-디메틸피페리딘-3-아민이염화물 (-)-디-p-톨루오일-L-타르타르산 N-메틸벤질아민 에틸말로닐클로라이드 4-메틸-3-메틸아미노피리딘 벤질-N,4-디메틸피페리딘-3-아민디하이드로클로라이드(dr>98/2) 3-비스(4-메틸벤조일옥시)숙시네이트) 3-메톡시카르보닐아미노-4-메틸피리딘 6-아미노-5-(2,2-디에톡시에틸)피리미딘-4-올 4-클로로-6,7-디히드로-5H-피롤로[2,3-d]피리미딘 1-벤질-4-메틸-피페리딘-3-온염산염 시아노아세트산-오스