CAL-101
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CAL-101 속성
- 녹는점
- 250-252oC
- 끓는 점
- 733.4±70.0 °C(Predicted)
- 밀도
- 1.47
- 저장 조건
- -20°C
- 용해도
- DMSO에 용해됨(>25 mg/ml)
- 물리적 상태
- 백색 고체.
- 산도 계수 (pKa)
- 10.00±0.10(Predicted)
- 색상
- 하얀색
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO의 솔루션은 -20°C에서 최대 2개월 동안 보관할 수 있습니다.
- InChIKey
- IFSDAJWBUCMOAH-HNNXBMFYSA-N
- SMILES
- N1C2=C(C(F)=CC=C2)C(=O)N(C2=CC=CC=C2)C=1[C@@H](NC1=C2C(=NC=N1)NC=N2)CC
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 안전지침서 | V | ||
|---|---|---|---|
| HS 번호 | 29399990 | ||
| 유해 물질 데이터 | 870281-82-6(Hazardous Substances Data) |
| 그림문자(GHS): |
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| 신호 어: | Danger | ||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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CAL-101 C화학적 특성, 용도, 생산
용도
CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor.정의
ChEBI: A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indol nt non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.in vitro
CAL-101 (Idelalisib) is a highly selective and potent p110δ inhibitor (EC50=8 nM). Greater selectivity (400- to 4000-fold) is seen against related kinases C2β, hVPS34, DNA-PK, and mTOR, whereas no activity is observed against a panel of 402 diverse kinases at 10 μM. CAL-101 reduces PDGF-induced pAkt by only 25% at 10 μM. Idelalisib (CAL-101) inhibits LPA-induced pAkt with an EC50 of 1.9 μM. Idelalisib (CAL-101) blocks Fc?RI p110δ-mediated CD63 expression with an EC50 of 8 nM, whereas formyl-methionyl-leucyl-phenylalanine activation of p110γ is inhibited with an EC50 of 3 μM. Thus, CAL-101 has 240- to 2500-fold selectivity in cell-based assays for p110δ over the other class I PI3K isoforms. CAL-101Idelalisib (CAL-101)-induced apoptosis of chronic lymphocytic leukemia (CLL) cells is significant compared with vehicle treatment alone (P<0.001). Idelalisib (CAL-101) induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics.CAL-101 준비 용품 및 원자재
원자재
준비 용품
CAL-101 공급 업체
글로벌( 322)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 |
sales001@rokechem.com | China | 255 | 58 |
| Protheragen-ING | +16313385890 |
info@protheragen-ing.com | United States | 3868 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 |
faithe@yan-xi.com | China | 5853 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 |
sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| Lianyungang happen teng technology co., LTD | 15950718863 |
wang666xt@163.com | CHINA | 295 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29852 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 |
stella@zetchem.com | China | 2161 | 58 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 965 | 58 |
| Hangzhou Cyanochem Co., Ltd. | +86 17788583750 |
sales@cyanochem.com | CHINA | 281 | 58 |
CAL-101 관련 검색:
볼리티닙 2-플루오로-6-니트로-N-페닐벤즈아미드 BKM120(NVP-BKM120,부팔리십) 이브루티니브
IPI 145
Pictilisib
Bortezomib
Everolimus
(S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate
BOC-ABU-OH
(S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
2-Amino-6-fluorobenzoic acid
Dovitinib
ARRY-334543
Momelotinib
CO-1686
Selumetinib Sulfate
790299-79-5