Nisoldipine
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Nisoldipine 속성
- 녹는점
- 147-148°C
- 끓는 점
- 503.3±50.0 °C(Predicted)
- 밀도
- 1.205±0.06 g/cm3(Predicted)
- 저장 조건
- room temp
- 용해도
- DMSO: >10mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 2.67±0.70(Predicted)
- 색상
- 노란색
- Merck
- 14,6565
- InChI
- 1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
- InChIKey
- VKQFCGNPDRICFG-UHFFFAOYSA-N
- SMILES
- COC(=O)C1=C(C)NC(C)=C(C1c2ccccc2[N+]([O-])=O)C(=O)OCC(C)C
- CAS 데이터베이스
- 63675-72-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 20/21/22 | ||
| 안전지침서 | 36 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | US7975600 | ||
| HS 번호 | 2933399090 | ||
| 스토리지 클래스 | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral |
Nisoldipine C화학적 특성, 용도, 생산
개요
Nisoldipine D4 is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.화학적 성질
Nisoldipine D4 is Light Tan Crystals용도
Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.정의
ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, calcium channel blocker, is used in the treatment of hypertension and angina pectoris.일반 설명
In vitro studies show that the effects ofnisoldipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid methyl 2-methylpropyl ester(Sular), on contractile processes are selective, with greaterpotency on vascular smooth muscle than on cardiac muscle.Nisoldipine is highly metabolized, with five majormetabolites identified. As with most of the dihydropyridines,the cytochrome P450 (CYP) 3A4 isozyme is mainlyresponsible for the metabolism of nisoldipine. The majorbiotransformation pathway appears to involve the hydroxylationof the isobutyl ester side chain. This particular metabolitehas approximately 10% of the activity of the parentcompound.
Nisoldipine 준비 용품 및 원자재
원자재
3-아미노크로톤산메틸
2-니트로벤즈알레하이드
아세토아세트산이소부틸에스테르
nifedipine iMpurity C
NIFE디솔
이소부틸2-(2-니트로-벤질리덴)아세토아세테이트
Nicardipine
2,3-디아미노-2,3-디메틸부탄
메틸3-아미노크로토네이트
4-다이메틸아미노피리딘
준비 용품
Nisoldipine 공급 업체
글로벌( 410)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 |
Sibel@chuanghaibio.com | China | 8737 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21531 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3618 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29766 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | +86-0531-88110457 +86-15562555968 |
info@pharmachemm.com | China | 302 | 58 |
| Hebei Jimi Trading Co., Ltd. | +86 319 5273535 |
bestoneforyou@sina.com | CHINA | 282 | 58 |
| CONIER CHEM AND PHARMA LIMITED | |
sales@conier.com | China | 49906 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 |
marketing@targetmol.com | United States | 32431 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 |
1059@dideu.com | China | 9984 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 |
info@afinechem.com | China | 15058 | 58 |