4-Chloro-7-azaindole
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4-Chloro-7-azaindole 속성
- 녹는점
- 176-181 °C
- 밀도
- 1.425±0.06 g/cm3(Predicted)
- 저장 조건
- under inert gas (nitrogen or Argon) at 2-8°C
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 12.98±0.40(Predicted)
- 색상
- 밝은 노란색에서 갈색까지
- 수용성
- 물에 약간 용해됩니다.
- InChI
- InChI=1S/C7H5ClN2/c8-6-2-4-10-7-5(6)1-3-9-7/h1-4H,(H,9,10)
- InChIKey
- HNTZVGMWXCFCTA-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=C(Cl)C=CN=2
- CAS 데이터베이스
- 55052-28-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-37/38-41 | ||
| 안전지침서 | 26-39 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| 위험 등급 | IRRITANT | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | Ⅲ | ||
| HS 번호 | 29339900 |
4-Chloro-7-azaindole C화학적 특성, 용도, 생산
개요
4-Chloro-7-azaindole belongs to the class of azaindole compounds, which has anticancer, antibacterial, antiviral and other biological activities. 4-Chloro-7-azaindole is mainly used as an organic intermediate in the preparation of 7-azaindole derivatives, GDC-0575, and Janus kinase inhibitors.화학적 성질
White to brown solid용도
4-Chloro-7-azaindole can be used as a useful intermediate for drug discovery research.제조 방법
Using 7-azaindole as the raw material, hydrogen peroxide was used to carry out N-oxidation reaction to generate N-oxide. In the reaction between POCl? and N-oxide, diisopropylethylamine (DIPEA) was added as a catalyst to increase the yield. After the reaction was completed, 4-Chloro-7-azaindole was obtained by alkalization treatment with a yield of up to 85.6%.Synthesis Reference(s)
The Journal of Organic Chemistry, 71, p. 4021, 2006 DOI: 10.1021/jo06025714-Chloro-7-azaindole 준비 용품 및 원자재
원자재
7-Azaindole
3-클로로페록시벤조산
포스포러스옥시클로라이드
Benzoic acid, 3-chloro-, compd. with 7-hydroxy-7H-pyrrolo[2,3-b]pyridine (1:1)
메탄설포닐 클로라이드
7-옥사이드-7-아자인돌
헵테인
1,2-다이메톡시에테인
trichlorophosphate
준비 용품
4-Chloro-7-azaindole 공급 업체
글로벌( 547)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Suzhou Ryan Pharmachem Technology Co.,Ltd. | +86-512-68780025 +8618962125825 |
sales@ryanchem.com | China | 262 | 58 |
| Terma Medicare India Pvt.,Ltd | +86-53530655; +8613916485955 |
shivshanghai@yahoo.com | India | 279 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 |
sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 |
info@dakenam.com | China | 13456 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21620 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29852 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 |
act@arborchemical.com | CHINA | 904 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 8497 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 |
sales@finerchem.com | China | 2953 | 58 |
4-Chloro-7-azaindole 관련 검색:
1-클로로메틸-1H-1,2,4-트리아졸 인드메타신 클로피돌 인돌-3-아세트산 3-인돌부틸산 2-클로로-5-클로로메틸피리딘 피리딘 tert-부틸7-옥소-2,6-디아자스피로[3.4]옥탄-2-카르복실레이트 1-벤질아제티딘-3-올 4-클로로-5-플루오로-2-(메타… 2-((5-클로로피리딘-2-일)아미노)-2-옥소아세트산 메틸(R)-1-Boc-4,4-디플루오로피롤리딘-2-카르복실레이트 6-브로모-4-인돌카복실산메틸에스테르 6-메톡시인돌 7-아자비시클로[2,2,1]헵탄염산염 디에틸1H-피롤-2,4-디카르복실레이트 1H-피롤로[2,3-B]피리딘-5-OL 3-BroMo-5-니트로-1H-피라조…