독시시크린 히클라산염
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독시시크린 히클라산염 속성
- 녹는점
- 206-209C (dec.)
- 알파
- D25 -110° (c = 1 in 0.01N methanolic HCl)
- RTECS 번호
- QI8925000
- 저장 조건
- 2-8°C
- 용해도
- H2O: 용해성50mg/mL
- 물리적 상태
- 노란색~황록색 결정성 고체
- 색상
- 노란색에서 녹황색까지
- 생물학적 소스
- synthetic
- 수용성
- 50mg/ml까지 물에 용해됩니다. 예열이 필요할 수 있습니다. 물, 메탄올에 용해됩니다. 에탄올에 거의 용해되지 않습니다. 클로로포름과 에테르에 불용성.
- Merck
- 14,3440
- BRN
- 5702728
- 주요 응용
- 임상 시험
- InChIKey
- HALQELOKLVRWRI-VDBOFHIQSA-N
- SMILES
- C(O)C.O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]([C@]1([H])[C@H](C3C=CC=C(O)C=3C(=O)C1=C2O)C)O)=O.Cl |&1:4,12,16,18,19,21,r|
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38 | ||
| 안전지침서 | 26 | ||
| WGK 독일 | 3 | ||
| HS 번호 | 29413000 | ||
| 스토리지 클래스 | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 3 Eye Irrit. 2 Repr. 2 Skin Irrit. 2 STOT SE 3 |
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| 독성 | LD50 i.p. in rats: 262 mg/kg (Goldenthal) | ||
| 기존화학 물질 | KE-11171 |
독시시크린 히클라산염 C화학적 특성, 용도, 생산
개요
Doxycycline Hyclate is the hyclate salt form of doxycycline, is a broad-spectrum tetracycline antibiotic. It inhibits bacterial protein synthesis by binding to ribosomes. Doxycycline also selectively inhibits human matrix metalloproteinase-8 (MMP-8) and MMP-13 over MMP-1 with 50, 60, and 5% inhibition, respectively, when used at a concentration of 30 μM. It can be used as a regulator for inducible gene expression systems where expression depends on either the presence (Tet-On) or absence (Tet-Off) of doxycycline. Formulations containing doxycycline have been used in the treatment of bacterial infections and the prevention of malaria.화학적 성질
Doxycycline hyclate is a yellow, hygroscopic crystalline powder, freely soluble in water and in methanol, sparingly soluble in ethanol (96 per cent), it dissolves in solutions of alkali hydroxides and carbonates.용도
Doxycycline hyclate is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is used in the treatment of chlamydia, rickettsia, mycoplasma and some spirochete infections. It is also used to inhibit matrix metalloproteinases at subantimicrobial doses. Inhibits matrix metalloproteinases at subantimicrobial doses.정의
ChEBI: The hemiethanolate hemihydrate of doxycycline hydrochloride. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chroni obstructive pulmonary disease (COPD), and adult periodontitis.주요 응용
Doxycycline hyclate is a synthetic oxytetracycline derivative with similar antimicrobial activity. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is a broad spectrum inhibitor used to inhibit matrix metalloproteinases(MMP), such as type 1 collagenase in studies on wound healing and tissue remodeling. Doxycycline hyclate has also been used for the induction of glioma cells and human embryonic kidney 293T cells (HEK293T).World Health Organization (WHO)
Doxycycline, a semi-synthetic tetracycline derivative, was first introduced into medicine in 1960 for the treatment of bacterial, rickettsial and amoebic infections. Although allergic manifestations are uncommon, injectable preparations have occasionally resulted in severe anaphylactoid reactions. Clinical features and the fact that asthmatic patients seemed to be particularly at risk lead to suspect a sulfite preservative in the formulation more than doxycycline itself. Rapid administration may also be a factor. Injectable preparations of doxycycline hyclate are included in the WHO Model List of Essential Drugs.일반 설명
Doxycycline hyclate belongs to the second generation of tetracycline antibiotics family. Doxycycline hyclate shows minimal side effects upon usage. It is effective for the treatment of recurrent aphthous stomatitis (RAS) and promotes speedy recovery.Mode of action
Tetracycline antimicrobials bind to the bacterial 30S ribosomal subunit interfering with tRNA/mRNA interaction, ultimately inhibiting protein synthesis. Tetracyclines can inhibit the MMP enzyme family and inhibit mitochondrial biogenesis.독시시크린 히클라산염 준비 용품 및 원자재
원자재
준비 용품
독시시크린 히클라산염 공급 업체
글로벌( 754)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Qiande Pharmaceutical Co. LTD | 19103869591 |
1814581@qq.com | China | 213 | 58 |
| Hubei Wanye Zhongcheng Chemical Reagent Co., Ltd. | 18671296875 |
1205035102@qq.com | China | 4300 | 58 |
| Wuhan DingCheng Biochemical Co.Ltd | 81302558 13545255233 |
2851686513@qq.com | China | 745 | 58 |
| Suzhou Yuanhuan Pharmaceutical Technology Co., Ltd. | 0512-18136053398 18136053398 |
2982784935@qq.com | China | 80 | 58 |
| Hubei Yangyi Xinsheng Biological Medicine Co., LTD | 15927387803 15927387803 |
2263659332@qq.com | China | 168 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 |
jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 |
3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 |
Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 |
sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 |
2355560935@qq.com | China | 11777 | 60 |